Re-activation of HIF signalling pathway in the epicardium improves heart regeneration after myocardial infarction

Autor: E Gamen, EL Price, D Pezzolla, C De Villiers, M Gunadasa-Rohling, R Salama, DR Mole, T Bishop, CW Pugh, RP Choudhury, CA Carr, JM Vieira, PR Riley

Publikováno v: Cardiovascular Research. 118

Funding Acknowledgements Type of funding sources: Foundation. Main funding source(s): British Heart Foundation Background In mouse, cardiac regenerative capacity is maintained for the first week after birth but lost thereafter. Reactivation of this p

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https://doi.org/10.1093/cvr/cvac066.043

The age-dependent development of abnormal cardiac metabolism in the peroxisome proliferator-activated receptor α-knockout mouse.

Autor: Dodd MS; Cardiac Metabolism Research Group, Department of Physiology, Anatomy and Genetics, University of Oxford, United Kingdom; Centre for Health and Life Sciences, Coventry University, Coventry, United Kingdom. Electronic address: mike.dodd@coventry.ac.uk., Ambrose L; Cardiac Metabolism Research Group, Department of Physiology, Anatomy and Genetics, University of Oxford, United Kingdom., Ball V; Cardiac Metabolism Research Group, Department of Physiology, Anatomy and Genetics, University of Oxford, United Kingdom., Clarke K; Cardiac Metabolism Research Group, Department of Physiology, Anatomy and Genetics, University of Oxford, United Kingdom., Carr CA; Cardiac Metabolism Research Group, Department of Physiology, Anatomy and Genetics, University of Oxford, United Kingdom., Tyler DJ; Cardiac Metabolism Research Group, Department of Physiology, Anatomy and Genetics, University of Oxford, United Kingdom.

Publikováno v: Atherosclerosis [Atherosclerosis] 2024 Dec; Vol. 399, pp. 118599. Date of Electronic Publication: 2024 Sep 17.

Alkaline nucleoplasm facilitates contractile gene expression in the mammalian heart.

Autor: Hulikova A; Department of Physiology, Anatomy and Genetics, University of Oxford, Sherrington Building, Parks Road, Oxford, OX1 3PT, UK., Park KC; Department of Physiology, Anatomy and Genetics, University of Oxford, Sherrington Building, Parks Road, Oxford, OX1 3PT, UK., Loonat AA; Department of Physiology, Anatomy and Genetics, University of Oxford, Sherrington Building, Parks Road, Oxford, OX1 3PT, UK., Gunadasa-Rohling M; Department of Physiology, Anatomy and Genetics, University of Oxford, Sherrington Building, Parks Road, Oxford, OX1 3PT, UK., Curtis MK; Department of Physiology, Anatomy and Genetics, University of Oxford, Sherrington Building, Parks Road, Oxford, OX1 3PT, UK., Chung YJ; Department of Physiology, Anatomy and Genetics, University of Oxford, Sherrington Building, Parks Road, Oxford, OX1 3PT, UK., Wilson A; Department of Physiology, Anatomy and Genetics, University of Oxford, Sherrington Building, Parks Road, Oxford, OX1 3PT, UK., Carr CA; Department of Physiology, Anatomy and Genetics, University of Oxford, Sherrington Building, Parks Road, Oxford, OX1 3PT, UK., Trafford AW; Unit of Cardiac Physiology, Division of Cardiovascular Sciences, University of Manchester, Manchester, UK., Fournier M; Department of Biochemistry, Advanced Proteomics Facility, University of Oxford, Oxford, UK., Moshnikova A; Physics Department, University of Rhode Island, 2 Lippitt Rd, Kingston, RI, 02881, USA., Andreev OA; Physics Department, University of Rhode Island, 2 Lippitt Rd, Kingston, RI, 02881, USA., Reshetnyak YK; Physics Department, University of Rhode Island, 2 Lippitt Rd, Kingston, RI, 02881, USA., Riley PR; Department of Physiology, Anatomy and Genetics, University of Oxford, Sherrington Building, Parks Road, Oxford, OX1 3PT, UK., Smart N; Department of Physiology, Anatomy and Genetics, University of Oxford, Sherrington Building, Parks Road, Oxford, OX1 3PT, UK., Milne TA; MRC Molecular Haematology Unit, Radcliffe Department of Medicine, MRC Weatherall Institute of Molecular Medicine, NIHR Oxford Biomedical Research Centre Haematology Theme, University of Oxford, Oxford, UK., Crump NT; MRC Molecular Haematology Unit, Radcliffe Department of Medicine, MRC Weatherall Institute of Molecular Medicine, NIHR Oxford Biomedical Research Centre Haematology Theme, University of Oxford, Oxford, UK., Swietach P; Department of Physiology, Anatomy and Genetics, University of Oxford, Sherrington Building, Parks Road, Oxford, OX1 3PT, UK. pawel.swietach@dpag.ox.ac.uk.

Publikováno v: Basic research in cardiology [Basic Res Cardiol] 2022 Mar 31; Vol. 117 (1), pp. 17. Date of Electronic Publication: 2022 Mar 31.

Diabetic mitochondria are resistant to palmitoyl CoA inhibition of respiration, which is detrimental during ischemia.

Autor: Kerr M; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK., Dennis KMJH; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK., Carr CA; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK., Fuller W; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK., Berridge G; Target Discovery Institute, University of Oxford, Oxford, UK., Rohling S; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK., Aitken CL; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK., Lopez C; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK., Fischer R; Target Discovery Institute, University of Oxford, Oxford, UK., Miller JJ; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.; Department of Physics, University of Oxford, Oxford, UK.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Clarke K; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK., Tyler DJ; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Heather LC; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.

Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2021 Aug; Vol. 35 (8), pp. e21765.

Physiological and pharmacological stimulation for in vitro maturation of substrate metabolism in human induced pluripotent stem cell-derived cardiomyocytes.

Autor: Lopez CA; Department of Physiology, Anatomy and Genetics, University of Oxford, Sherrington Building, Parks Road, Oxford, OX1 3PT, UK.; School of Medicine's Cardiovascular Medicine Research Center, Yale University, 300 George Street, New Haven, CT, 06511, USA., Al-Siddiqi HHAA; Department of Physiology, Anatomy and Genetics, University of Oxford, Sherrington Building, Parks Road, Oxford, OX1 3PT, UK.; Qatar Biomedical Research Institute, Hamad Bin Khalifa University, Education City, P.O. Box 34110, Doha, Qatar., Purnama U; Department of Physiology, Anatomy and Genetics, University of Oxford, Sherrington Building, Parks Road, Oxford, OX1 3PT, UK., Iftekhar S; Department of Material Science, University of Oxford, Parks Road, Oxford, OX1 3PH, UK., Bruyneel AAN; Department of Physiology, Anatomy and Genetics, University of Oxford, Sherrington Building, Parks Road, Oxford, OX1 3PT, UK., Kerr M; Department of Physiology, Anatomy and Genetics, University of Oxford, Sherrington Building, Parks Road, Oxford, OX1 3PT, UK., Nazir R; Department of Material Science, University of Oxford, Parks Road, Oxford, OX1 3PH, UK.; Interdisciplinary Research Centre in Biomedical Materials, COMSATS University Islamabad, Lahore Campus, 1.5 KM Defence Road Off Raiwind Road, Lahore, Pakistan., da Luz Sousa Fialho M; Department of Physiology, Anatomy and Genetics, University of Oxford, Sherrington Building, Parks Road, Oxford, OX1 3PT, UK., Malandraki-Miller S; Department of Physiology, Anatomy and Genetics, University of Oxford, Sherrington Building, Parks Road, Oxford, OX1 3PT, UK., Alonaizan R; Department of Physiology, Anatomy and Genetics, University of Oxford, Sherrington Building, Parks Road, Oxford, OX1 3PT, UK., Kermani F; Department of Physiology, Anatomy and Genetics, University of Oxford, Sherrington Building, Parks Road, Oxford, OX1 3PT, UK., Heather LC; Department of Physiology, Anatomy and Genetics, University of Oxford, Sherrington Building, Parks Road, Oxford, OX1 3PT, UK., Czernuszka J; Department of Material Science, University of Oxford, Parks Road, Oxford, OX1 3PH, UK., Carr CA; Department of Physiology, Anatomy and Genetics, University of Oxford, Sherrington Building, Parks Road, Oxford, OX1 3PT, UK. Carolyn.carr@dpag.ox.ac.uk.

Publikováno v: Scientific reports [Sci Rep] 2021 Apr 08; Vol. 11 (1), pp. 7802. Date of Electronic Publication: 2021 Apr 08.