Zobrazeno 1 - 10
of 38
pro vyhledávání: '"C8 complex"'
Autor:
Marin Anca Elena, Pantoc Camelia, Baducu Diana Elena, Capitanescu Andrei, Stoica Cristina, Constantinescu Iulia, Lungu Adrian Catalin, Niculae Alexandra, Negru Ileana, Viziniuc Ana-Maria
Publikováno v:
Posters.
Background and aims Patients with persistent deficiencies in the complement pathway have an increased risk for meningococcal infection and can experience recurrent disease. In this group we can include genetic deficiencies, functional or anatomic asp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6fda823711f2aa97b088302321b92a89
https://doi.org/10.1136/archdischild-2017-313273.343
https://doi.org/10.1136/archdischild-2017-313273.343
Autor:
Sanjay Ram, Lisa A. Lewis
Publikováno v:
Virulence
Despite considerable advances in the understanding of the pathogenesis of meningococcal disease, this infection remains a major cause of morbidity and mortality globally. The role of the complement system in innate immune defenses against invasive me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5adca8236decd811c50dd8782e5ef3f1
https://doi.org/10.4161/viru.26515
https://doi.org/10.4161/viru.26515
Publikováno v:
APMIS. 119:479-484
Invasive meningococcal disease is a world wide challenge. Most cases occur in immunocompetent children and young adults, but some immunodeficiencies are linked to a greater risk of invasive neisserial infections. One of these is complement component
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9267d909f7337f930f5d7de912e5ec1e
https://doi.org/10.1111/j.1600-0463.2011.02740.x
https://doi.org/10.1111/j.1600-0463.2011.02740.x
Publikováno v:
Clinical Microbiology Reviews. 23:740-780
SUMMARY The complement system comprises several fluid-phase and membrane-associated proteins. Under physiological conditions, activation of the fluid-phase components of complement is maintained under tight control and complement activation occurs pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::384e6a0837caa66aeb41511056d6628d
https://doi.org/10.1128/cmr.00048-09
https://doi.org/10.1128/cmr.00048-09
Publikováno v:
Annals of the New York Academy of Sciences. 1173:108-123
The complement system is composed of more than 30 serum and membrane-bound proteins, all of which are needed for normal function of complement in innate and adaptive immunity. Historically, deficiencies within the complement system have been suspecte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d24f1ecbffd6c509e2319bddbfd462d7
https://doi.org/10.1111/j.1749-6632.2009.04633.x
https://doi.org/10.1111/j.1749-6632.2009.04633.x
Autor:
Connie Tran, Ann E. Jerse, Sunita Gulati, Sanjay Ram, Peter A. Rice, Jutamas Ngampasutadol, Anna M. Blom
Publikováno v:
Vaccine. 26:I62-I66
Neisseria gonorrhoeae is the causative agent of gonorrhea, a disease restricted to humans. Complement forms a key arm of the innate immune system that combats gonococcal infections. N. gonorrhoeae uses its outer membrane porin (Por) molecules to bind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf62f7adb352659742299b391dcd6431
https://doi.org/10.1016/j.vaccine.2008.11.051
https://doi.org/10.1016/j.vaccine.2008.11.051
Publikováno v:
Trends in Microbiology. 15:233-240
Meningococcal infection remains a worldwide health problem, and understanding the mechanisms by which Neisseria meningitidis evades host innate and acquired immunity is crucial. The complement system is vital for protecting individuals against N. men
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2ed2ab3f11541f43546e18f8f931b92
https://doi.org/10.1016/j.tim.2007.03.005
https://doi.org/10.1016/j.tim.2007.03.005
Autor:
Anna M. Blom
Publikováno v:
Scandinavian Journal of Clinical and Laboratory Investigation. 64:479-496
The complement system is an important part of innate immunity providing immediate protection against pathogens without a need for previous exposure. Its importance is clearly shown by the fact that patients lacking complement components suffer from f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df37149786f7a07fdd5d845358c998c6
https://doi.org/10.1080/00365510410002904
https://doi.org/10.1080/00365510410002904
Autor:
Jack Eaton, Philip N. Ward, Matthew C. Pickering, Talat H. Malik, Joseph J. E. Caesar, Susan M. Lea, Elena Goiecoechea De Jorge, Christoph M. Tang, Rachel M. Exley, Hayley Lavender, Emily Chittock
Publikováno v:
eLife
eLife, Vol 3 (2014)
eLife, Vol 3 (2014)
Genome-wide association studies have found variation within the complement factor H gene family links to host susceptibility to meningococcal disease caused by infection with Neisseria meningitidis (Davila et al., 2010). Mechanistic insights have bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1204326ff94b6e56cce8369a8e76eab
https://doi.org/10.7554/elife.04008
https://doi.org/10.7554/elife.04008
Publikováno v:
Pediatric Nephrology. 22:747-749
Chronic deficiencies in the complement pathway proteins are associated with an increased risk of meningococcal disease. Such deficiencies are caused by primary congenital immunodeficiency of a complement protein, properdin or mannose binding lectin,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3be9f55463539b70f5dbbcc216e85e35
https://doi.org/10.1007/s00467-006-0394-x
https://doi.org/10.1007/s00467-006-0394-x