A thermo-responsive, self-assembling biointerface for on demand release of surface-immobilised proteins

Autor: Enrico Ferrari, Angela Saccardo, Mikhail Soloviev

Publikováno v: Biomaterials science. 8(9)

Dedicated chemistries for on-demand capture and release of biomolecules at the solid–liquid interface are required for applications in drug delivery, for the synthesis of switchable surfaces used in analytical devices and for the assembly of next-g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2eab35e344c9a69b4ef3dc2453c7a2f9
https://pubmed.ncbi.nlm.nih.gov/32254844

A chicken bioreactor for efficient production of functional cytokines

Autor: Herron, Lissa R., Pridans, Clare, Turnbull, Matthew L., Smith, Nikki, Lillico, Simon, Sherman, Adrian, Gilhooley, Hazel J., Wear, Martin, Kurian, Dominic, Papadakos, Grigorios, Digard, Paul, Hume, David A., Gill, Andrew C., Sang, Helen M.

Publikováno v: BMC Biotechnology
BMC Biotechnology, Vol 18, Iss 1, Pp 1-12 (2018)
Herron, L R, Pridans, C, Turnbull, M L, Smith, N, Lillico, S, Sherman, A, Gilhooley, H J, Wear, M, Kurian, D, Papadakos, G, Digard, P, Hume, D A, Gill, A C & Sang, H M 2018, ' A chicken bioreactor for efficient production of functional cytokines ', BMC Biotechnology, vol. 18, no. 1, pp. 82 . https://doi.org/10.1186/s12896-018-0495-1

Background The global market for protein drugs has the highest compound annual growth rate of any pharmaceutical class but their availability, especially outside of the US market, is compromised by the high cost of manufacture and validation compared

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::95332fd2452987b173d2ce535f7d43cb
http://europepmc.org/articles/PMC6311007

Tetrahydrobiopterin modulates ubiquitin conjugation to UBC13/UBE2N and proteasome activity by S-nitrosation

Autor: Bailey, Jade, Shaw, Andrew, Diotavelli, Marina, Fischer, Roman, Benson, Matthew A, Zhu, Hanneng, Brown, James, Bhattacharya, Shoumo, Kessler, Benedikt M, Channon, Keith M, Crabtree, Mark J

Publikováno v: Scientific Reports

Nitric Oxide (NO) is an intracellular signalling mediator, which affects many biological processes via the posttranslational modification of proteins through S-nitrosation. The availability of NO and NOS-derived reactive oxygen species (ROS) from enz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::f05b54c72ad3864616b79f3edf6d1b21

The role of the mammalian prion protein in the control of sleep

Autor: Roguski, Amber, Gill, Andrew C

Publikováno v: Pathogens, Vol 6, Iss 4, p 58 (2017)
Roguski, A & Gill, A C 2017, ' The Role of the Mammalian Prion Protein in the Control of Sleep ', Pathogens, vol. 6, no. 4 . https://doi.org/10.3390/pathogens6040058

Sleep disruption is a prevalent clinical feature in many neurodegenerative disorders, including human prion diseases where it can be the defining dysfunction, as in the case of the "eponymous" fatal familial insomnia, or an early-stage symptom as in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::4b802c5289f826bd1039f6e6b06c795f
https://eprints.lincoln.ac.uk/id/eprint/29645/1/Roguski00058.pdf

Investigations into the potential anticancer activity of Maximin H5

Autor: Frederick Harris, Sarah R. Dennison, David A. Phoenix

Here we report the first major example of anionic amphibian host defence peptides (HDPs) with anticancer activity. Maximin H5 is a C-terminally amidated, anionic host defence peptide (MH5N) from toads of the Bombina genus, which was shown to possess

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fd94059ae2c2785f03d64265f3e49bd
https://clok.uclan.ac.uk/17217/1/Dennison_2017_accepted.pdf