Zobrazeno 1 - 10
of 5 183
pro vyhledávání: '"C57BL/6J"'
Publikováno v:
Zhongguo Linchuang Yixue, Vol 31, Iss 5, Pp 712-723 (2024)
Objective To explore the approach to establish a temporal lobe epilepsy model via intraperitoneal pilocarpine injection in C57BL/6J mice, and to summarize behavioral indicators predicting successful modeling during the acute phase of epileptic seizur
Externí odkaz:
https://doaj.org/article/39758758dd4e459898df8775cb717af5
Autor:
LeYuan Gu, WeiHui Shao, Lu Liu, Qing Xu, YuLing Wang, JiaXuan Gu, Yue Yang, ZhuoYue Zhang, YaXuan Wu, Yue Shen, Qian Yu, XiTing Lian, HaiXiang Ma, YuanLi Zhang, HongHai Zhang
Publikováno v:
eLife, Vol 13 (2024)
The advent of midazolam holds profound implications for modern clinical practice. The hypnotic and sedative effects of midazolam afford it broad clinical applicability. However, the specific mechanisms underlying the modulation of altered consciousne
Externí odkaz:
https://doaj.org/article/20ca8e0a75394714835daa95d8d3517f
Autor:
Agnieszka Rodzik, Paweł Pomastowski, Magdalena Buszewska-Forajta, Viorica Railean, Adrian Gołębiowski, Bogusław Buszewski, Katarzyna Niedojadło, Paweł Fijałkowski, Kinga Robotnik, Katarzyna Rafińska
Publikováno v:
Discover Nano, Vol 19, Iss 1, Pp 1-18 (2024)
Abstract This study explores the potential of zinc and silver nanocomposites, synthesized with β-lactoglobulin, a whey protein, in promoting wound healing, using the C57BL/6J mouse model. Our research is distinct in its dual focus: assessing the ant
Externí odkaz:
https://doaj.org/article/9b34f8c4df25495b9aa8123682725d3c
Publikováno v:
口腔疾病防治, Vol 32, Iss 9, Pp 664-673 (2024)
Objective To investigate the impact of metabolic labeling on Porphyromonas gingivalis (Pg) and compare the imaging effects of two fluorescent probes. Methods This study was reviewed by the unit Ethics Committee and was approved by the Experimental An
Externí odkaz:
https://doaj.org/article/e92f4acf51964e619a2adb3912fc23f9
Publikováno v:
Journal of Functional Foods, Vol 121, Iss , Pp 106407- (2024)
The aim of this study was to identify peptides in chickpea protein hydrolysate (CPH) capable of ameliorating the metabolic consequences of a high-fat diet (HFD) using a model of metabolic dysfunction. C57BL/6J male mice were randomly divided into thr
Externí odkaz:
https://doaj.org/article/2634818d1ec348d59b439922b1559ea3
Publikováno v:
Shiyan dongwu yu bijiao yixue, Vol 44, Iss 3, Pp 259-269 (2024)
Objective To establish a mouse model of pregnancy pain-depression comorbidity induced by chronic unpredictable stress (CUS), complete Freund's adjuvant (CFA), and formalin, and to systematically evaluate the associated phenotypes and preliminarily ex
Externí odkaz:
https://doaj.org/article/abbc9813f0b74a3fb9237557c16b7a31
Autor:
Ying Xiao, Xuefeng Hu, Wei Xing, Jie Yan, Ruhuan Wang, Xiaoqing Li, Jiahuan Li, Zhixin Zhang, Jingchao Sun, Junjun Wu
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
BackgroundEsketamine, the first Food and Drug Administration-approved fast-acting antidepressant, has limited use because of its addictive properties. Although the combination of dextromethorphan and bupropion partially addresses the limitations of e
Externí odkaz:
https://doaj.org/article/4f67c2dce63b47188d8cd7e4e6eed45c
Autor:
Agnes Carolin, David Frazer, Kexin Yan, Cameron R. Bishop, Bing Tang, Wilson Nguyen, Sheridan L. Helman, Jay Horvat, Thibaut Larcher, Daniel J. Rawle, Andreas Suhrbier
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
IntroductionThe severity of Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is often dictated by a range of comorbidities. A considerable literature suggests iron deficiency and iron over
Externí odkaz:
https://doaj.org/article/290d3d8be95a4ccda3ce6f0c5dc5c3ca
Autor:
Margit Wunderlich, Manuel Miller, Bärbel Ritter, Ronan Le Gleut, Hannah Marchi, Monir Majzoub-Altweck, Patrick J. Knerr, Jonathan D. Douros, Timo D. Müller, Markus Brielmeier
Publikováno v:
Molecular Metabolism, Vol 87, Iss , Pp 101992- (2024)
Objectives: We here assessed whether typical pathogens of laboratory mice affect the development of diet-induced obesity and glucose intolerance, and whether colonization affects the efficacy of the GLP-1R agonist liraglutide and of the GLP-1/GIP co-
Externí odkaz:
https://doaj.org/article/b004716fed8146a993a705755946285c
Autor:
LIANG Min, GUO Yang, WANG Jinjin, ZHU Mengyan, CHI Jun, CHEN Yanjuan, WANG Chengji, YU Zhilan, SHEN Ruling
Publikováno v:
Shiyan dongwu yu bijiao yixue, Vol 44, Iss 1, Pp 42-51 (2024)
Objective The aim is to utilize CRISPR/Cas9 gene editing technology to construct Dmd gene mutant mice with a point mutation in exon 23 of the Dmd gene. Subsequently, the phenotypic changes of the mice in muscles and immune systems are analyzed and ve
Externí odkaz:
https://doaj.org/article/1152b6457674413fb72977efc60826ca