Complement Component 5 (C5) Deficiency Improves Cognitive Outcome After Traumatic Brain Injury and Enhances Treatment Effects of Complement Inhibitors C1-Inh and CR2-Crry in a Mouse Model

Autor: Min Chen, Stephen R. Edwards, Dhiraj Maskey, Trent M. Woodruff, Stephen Tomlinson, David Reutens

Publikováno v: Neurotrauma Reports, Vol 4, Iss 1, Pp 663-681 (2023)

A potent effector of innate immunity, the complement system contributes significantly to the pathophysiology of traumatic brain injury (TBI). This study investigated the role of the complement cascade in neurobehavioral outcomes and neuropathology af

Externí odkaz: https://doaj.org/article/2ede2200b0034b69a923faab41e8b79f

Granulocyte and monocyte CD11b expression during plasma separation is dependent on complement factor 5 (C5) – an ex vivo study with blood from a C5-deficient individual

Autor: Hardersen, Randolf Inge, Enebakk, Terje, Christiansen, Dorte, Bergseth, Grete, Brekke, Ole-Lars, Mollnes, Tom Eirik, Lappegård, Knut Tore, Hovland, Anders

Publikováno v: Hardersen, R., Enebakk, T., Christiansen, D., Bergseth, G., Brekke, L.-O., Mollnes, T.E., ... Hovland, A.W. (2018). Granulocyte and monocyte CD11b expression during plasma separation is dependent on complement factor 5 (C5) – an ex vivo study with blood from a C5-deficient individual. Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS), 126(4), 342-352.

Externí odkaz: https://hdl.handle.net/10037/14970

Experimental Mouse Models of Disseminated Candida auris Infection

Autor: Karen E. Eberle, Hong Xin, Farhan Mohiuddin, Abby Adams, Jensen Tran

Publikováno v: mSphere, Vol 4, Iss 5 (2019)
mSphere
mSphere, Vol 4, Iss 5, p e00339-19 (2019)

In the last decade, Candida auris has emerged globally as a multidrug‐resistant fungal pathogen. Although C. auris was initially isolated from the external ear canal, it can cause outbreaks of invasive infections with very high mortality and comorb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ef19f1a36b5deec7d1d870c654eeca4
https://doi.org/10.1128/msphere.00339-19

Complement factor 5 (C5) p.A252T mutation is prevalent in, but not restricted to, sub-Saharan Africa: implications for the susceptibility to meningococcal disease

Autor: Manuel Hernández-González, Roger Colobran, Clara Franco-Jarava, David Comas, Ann Orren

Publikováno v: Recercat. Dipósit de la Recerca de Catalunya
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Complement C5 deficiency (C5D) is a rare primary immunodeficiency associated with recurrent infections, particularly meningitis, by Neisseria species. To date, studies to elucidate the molecular basis of hereditary C5D have included fewer than 40 fam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af293aa755f19cc49be964430da12337
http://hdl.handle.net/10230/35736

Primary complement C5 deficiencies – Molecular characterization and clinical review of two families

Autor: Tom Eirik Mollnes, Henrik Permin, Knut Tore Lappegård, Lone Schejbel, Peter Garred, Dag Fadnes

Publikováno v: Immunobiology. 218:1304-1310

Inherited deficiency states of the terminal complement component C5 are rare and often associated with increased risk of recurrent Neisseria infections. More than 50 cases with primary C5 deficiency have been reported. In spite of this, the molecular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caec6d5ad22092a07dfa8d55a2fe58fc
https://doi.org/10.1016/j.imbio.2013.04.021