The plasma level of complement component 4A decreases with aripiprazole treatment in patients with early psychosis.

Autor: Liu CM; Department of Psychiatry, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan; Neurobiology and Cognitive Science Center, National Taiwan University, Taipei, Taiwan. Electronic address: cmliu1968@ntu.edu.tw., Liu CC; Department of Psychiatry, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan., Hsieh MH; Department of Psychiatry, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan., Hwang TJ; Department of Psychiatry, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan; Neurobiology and Cognitive Science Center, National Taiwan University, Taipei, Taiwan., Lin YT; Department of Psychiatry, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan., Chien YL; Department of Psychiatry, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan., Hwu HG; Department of Psychiatry, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.

Publikováno v: Psychiatry research [Psychiatry Res] 2022 Oct; Vol. 316, pp. 114775. Date of Electronic Publication: 2022 Aug 07.

Complement component 4A protein levels are negatively related to frontal volumes in patients with schizophrenia spectrum disorders.

Autor: Gangadin SS; University of Groningen, Department of Psychiatry, University Medical Center Groningen (UMCG), Groningen, the Netherlands. Electronic address: s.s.gangadin@umcutrecht.nl., Germann M; University of Groningen, Department of Psychiatry, University Medical Center Groningen (UMCG), Groningen, the Netherlands., de Witte LD; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, USA., Gelderman KA; Sanquin Diagnostic Services, Amsterdam, the Netherlands., Mandl RCW; University of Groningen, Department of Psychiatry, University Medical Center Groningen (UMCG), Groningen, the Netherlands., Sommer IEC; University of Groningen, Department of Psychiatry, University Medical Center Groningen (UMCG), Groningen, the Netherlands.

Publikováno v: Schizophrenia research [Schizophr Res] 2023 Nov; Vol. 261, pp. 6-14. Date of Electronic Publication: 2023 Sep 06.

Impact of Homozygous C4A Deficiency on Clinical Presentation of Systemic Lupus Erythematosus.

Autor: Ansari AA; Department of Immunology, Armed Forces Institute of Pathology, CMH Rawalpindi, Pakistan., Tipu HN; Department of Immunology, Armed Forces Institute of Pathology, CMH Rawalpindi, Pakistan., Ahmad D; Department of Immunology, Armed Forces Institute of Pathology, CMH Rawalpindi, Pakistan., Farhan M; Armed Force Bone Marrow Transplant Center, CMH Rawalpindi, Pakistan.

Publikováno v: Journal of the College of Physicians and Surgeons--Pakistan : JCPSP [J Coll Physicians Surg Pak] 2020 Aug; Vol. 30 (8), pp. 790-795.

Cerebrospinal fluid concentration of complement component 4A is increased in first episode schizophrenia.

Autor: Gracias J; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden., Orhan F; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden., Hörbeck E; The Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden.; Psychosis Clinic, Sahlgrenska University Hospital, Mölndal, Sweden., Holmén-Larsson J; The Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden., Khanlarkani N; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden., Malwade S; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden., Goparaju SK; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden., Schwieler L; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden., Demirel İŞ; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden., Fu T; Center for Quantitative Health, Center for Genomic Medicine and Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA., Fatourus-Bergman H; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.; Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden., Pelanis A; Department of Anesthesiology, Sahlgrenska University Hospital, Gothenburg, Sweden., Goold CP; Novartis Institutes of BioMedical Research, Cambridge, MA, USA., Goulding A; Psychosis Clinic, Sahlgrenska University Hospital, Mölndal, Sweden.; Department of Psychology, University of Gothenburg, Gothenburg, Sweden., Annerbrink K; Psychosis Clinic, Sahlgrenska University Hospital, Mölndal, Sweden., Isgren A; The Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden.; Psychosis Clinic, Sahlgrenska University Hospital, Mölndal, Sweden., Sparding T; The Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden., Schalling M; Department of Molecular Medicine and Surgery, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden., Yañez VAC; NMI Natural and Medical Sciences Institute at the University of Tübingen, Reutlingen, Germany., Göpfert JC; NMI Natural and Medical Sciences Institute at the University of Tübingen, Reutlingen, Germany., Nilsson J; The Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden., Brinkmalm A; The Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden., Blennow K; The Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden., Zetterberg H; The Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.; Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, UK.; UK Dementia Research Institute at UCL, London, UK.; Hong Kong Center for Neurodegenerative Diseases, Hong Kong, China., Engberg G; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden., Piehl F; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden., Sheridan SD; Center for Quantitative Health, Center for Genomic Medicine and Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA., Perlis RH; Center for Quantitative Health, Center for Genomic Medicine and Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA., Cervenka S; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.; Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden.; Department of Medical Sciences, Psychiatry, Uppsala University, Uppsala, Sweden., Erhardt S; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden., Landen M; The Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden.; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Sellgren CM; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden. carl.sellgren@ki.se.; Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden. carl.sellgren@ki.se.

Publikováno v: Nature communications [Nat Commun] 2022 Nov 03; Vol. 13 (1), pp. 6427. Date of Electronic Publication: 2022 Nov 03.

Low copy numbers of complement C4 and C4A deficiency are risk factors for myositis, its subgroups and autoantibodies.

Autor: Zhou D; Center for Microbial Pathogenesis, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, Ohio, USA.; Division of Rheumatology, Nationwide Children's Hospital and Department of Pediatrics, The Ohio State University, Columbus, Ohio, USA., King EH; Center for Microbial Pathogenesis, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, Ohio, USA.; Division of Rheumatology, Nationwide Children's Hospital and Department of Pediatrics, The Ohio State University, Columbus, Ohio, USA., Rothwell S; National Institute for Health Research Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, The University of Manchester, Manchester, UK.; Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Krystufkova O; Institute of Rheumatology and Department of Rheumatology, Charles University, Prague, Czech Republic., Notarnicola A; Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet, University Hospital Karolinska, Stockholm, Sweden., Coss S; Center for Microbial Pathogenesis, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, Ohio, USA.; Division of Rheumatology, Nationwide Children's Hospital and Department of Pediatrics, The Ohio State University, Columbus, Ohio, USA., Abdul-Aziz R; Division of Rheumatology, Nationwide Children's Hospital and Department of Pediatrics, The Ohio State University, Columbus, Ohio, USA.; Division of Allergy/Immunology and Rheumatology, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY, USA., Miller KE; Center for Microbial Pathogenesis, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, Ohio, USA.; Division of Rheumatology, Nationwide Children's Hospital and Department of Pediatrics, The Ohio State University, Columbus, Ohio, USA., Dang A; Center for Microbial Pathogenesis, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, Ohio, USA., Yu GR; Center for Microbial Pathogenesis, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, Ohio, USA., Drew J; Division of Rheumatology, Nationwide Children's Hospital and Department of Pediatrics, The Ohio State University, Columbus, Ohio, USA., Lundström E; Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet, University Hospital Karolinska, Stockholm, Sweden., Pachman LM; Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Mamyrova G; Division of Rheumatology, Department of Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC, USA., Curiel RV; Division of Rheumatology, Department of Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC, USA., De Paepe B; Department of Neurology, Ghent University Hospital, Ghent, Belgium., De Bleecker JL; Department of Neurology, Ghent University Hospital, Ghent, Belgium., Payton A; Division of Informatics, Imaging and Data Sciences, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Ollier W; Faculty of Science and Engineering, Manchester Metropolitan University, Manchester, UK., O'Hanlon TP; Environmental Autoimmunity Group, Clinical Research Branch, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health, Bethesda, MD, USA., Targoff IN; Veteran's Affairs Medical Center, University of Oklahoma Health Sciences Center, and Oklahoma Medical Research Foundation, Oklahoma City, OK, USA., Flegel WA; Department of Transfusion Medicine, NIH Clinical Center, National Institutes of Health, Bethesda, MD, USA., Sivaraman V; Division of Rheumatology, Nationwide Children's Hospital and Department of Pediatrics, The Ohio State University, Columbus, Ohio, USA., Oberle E; Division of Rheumatology, Nationwide Children's Hospital and Department of Pediatrics, The Ohio State University, Columbus, Ohio, USA., Akoghlanian S; Division of Rheumatology, Nationwide Children's Hospital and Department of Pediatrics, The Ohio State University, Columbus, Ohio, USA., Driest K; Division of Rheumatology, Nationwide Children's Hospital and Department of Pediatrics, The Ohio State University, Columbus, Ohio, USA., Spencer CH; University of Mississippi Medical Center, Jackson, Mississippi, USA., Wu YL; Division of Rheumatology, Nationwide Children's Hospital and Department of Pediatrics, The Ohio State University, Columbus, Ohio, USA.; Department of Microbiology and Immunology, Loyola University Chicago, Maywood, IL, USA., Nagaraja HN; Division of Biostatistics, The Ohio State University, Columbus, Ohio, USA., Ardoin SP; Division of Rheumatology, Nationwide Children's Hospital and Department of Pediatrics, The Ohio State University, Columbus, Ohio, USA., Chinoy H; National Institute for Health Research Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, The University of Manchester, Manchester, UK.; Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Rider LG; Environmental Autoimmunity Group, Clinical Research Branch, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health, Bethesda, MD, USA., Miller FW; Environmental Autoimmunity Group, Clinical Research Branch, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health, Bethesda, MD, USA., Lundberg IE; Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet, University Hospital Karolinska, Stockholm, Sweden., Padyukov L; Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet, University Hospital Karolinska, Stockholm, Sweden., Vencovský J; Institute of Rheumatology and Department of Rheumatology, Charles University, Prague, Czech Republic., Lamb JA; Division of Population Health, Health Services Research and Primary Care, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Yu CY; Center for Microbial Pathogenesis, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, Ohio, USA Chack-Yung.Yu@nationwidechildrens.org.; Division of Rheumatology, Nationwide Children's Hospital and Department of Pediatrics, The Ohio State University, Columbus, Ohio, USA.

Publikováno v: Annals of the rheumatic diseases [Ann Rheum Dis] 2023 Feb; Vol. 82 (2), pp. 235-245. Date of Electronic Publication: 2022 Sep 28.