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Novel methods to determine complement activation in human serum induced by the complex of Dezamizumab and serum amyloid P

Autor: Jianhong Ma, John R. White, Qi Liu

Publikováno v: The Journal of Biological Chemistry

Lack of simple and robust methods to determine complement activation in human serum induced by antigen-antibody complexes is a major hurdle for monitoring therapeutic antibody drug quality and stability. Dezamizumab is a humanized IgG1 monoclonal ant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8f933513331869a4d84c72fbc9ba7fd
http://europepmc.org/articles/PMC8463879

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An analysis of functional activity via the three complement pathways during hemodialysis sessions: a new insight into the association between the lectin pathway and C5 activation

Autor: Hiroyuki Inoshita, Kisara Onda, Yasuhiko Tomino, Satoshi Horikoshi, Hiroyuki Ohi, Isao Ohsawa, Mariko Tamano

Publikováno v: Clinical Kidney Journal

Background. We have recently demonstrated that hemodialysis (HD) patients have significantly higher levels of functional complement activity (FCA) in all three pathways, i.e. the classical pathway, alternative pathway and lectin pathway (LP), than in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb1a4dded3357af59625a4d6bd16a168
http://europepmc.org/articles/PMC4432408

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Akademický článek

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Re-evaluation of the storage conditions for blood samples which are used for determination of complement activation

Autor: Jörg Köhl, Wilfried Bautsch, Andreas Klos, S Stöve

Publikováno v: Scopus-Elsevier

EDTA-blood samples derived either from healthy staff or septic patients were investigated for in vitro complement activation during the first 48 h after blood drawing at 4 degrees C and 20 degrees C. For this purpose C3a/C3a desArg plasma levels were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee3095f65e60eb65c1b8bb1a743d1602
https://doi.org/10.1016/0022-1759(95)00012-y

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Detection of colorectal adenoma and cancer based on transthyretin and C3a-desArg serum levels

Autor: Heinz Joachim List, Jörg Spangenberg, Hartmut Juhl, Kerstin David, Monika Spörl, Peter Layer, Arnulf Dörner, Carsten Zornig, Anne-Kristin Fentz

Publikováno v: Proteomics. Clinical applications. 1(6)

Colorectal cancer is the second leading cause of cancer death, and it develops from benign colorectal adenomas in over 95% of patients. Early detection of these cancer precursors by screening tests and their removal can potentially eradicate more tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d77d523d0a32b88867d8a3b8b51299d
https://pubmed.ncbi.nlm.nih.gov/21136704

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C5L2 receptor is not involved in C3a / C3a-desArg-mediated enhancement of bone marrow hematopoietic cell migration to CXCL12

Autor: Norma P. Gerard, Bao Lu, Marek Honczarenko, Craig Gerard, Anne Nicholson-Weller, Leslie E. Silberstein

Publikováno v: Leukemia. 19:1682-1683

C5L2 receptor is not involved in C3a / C3a-desArg-mediated enhancement of bone marrow hematopoietic cell migration to CXCL12

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f3f97e71121573394f6e1a63bdb12c11
https://doi.org/10.1038/sj.leu.2403862

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Reply to ‘C5L2 receptor is not involved in C3a/C3a-desArg-mediated enhancement of bone marrow hematopoietic cell migration to CXCL12’ by Honczarenko et al

Autor: Ryan Reca, M Z Ratajczak, Marcin Wysoczynski

Publikováno v: Leukemia. 19:1684-1685

Reply to ‘C5L2 receptor is not involved in C3a/C3a-desArg-mediated enhancement of bone marrow hematopoietic cell migration to CXCL12’ by Honczarenko et al

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3b552640e90f37736807fea5464b8180
https://doi.org/10.1038/sj.leu.2403863

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Complement component C3a or C3a desArg as a new marker for estimation of local vital reactions in incised skin wounds

Autor: Fukutaro Takabe, Hiroyuki Inoue, Yuka Mori, Mineo Iwasa, Yoshitaka Maeno

Publikováno v: Forensic science international. 55(1)

The anaphylatoxin C3a or its desArg form ( C3a desArg ) generated during complement activation could be detected in the vicinity of incised skin wounds of guinea pigs using immunoblotting methods. The C3a desArg peptides were detectable immediately a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7563d97a4a6745adea83c053b8199f85
https://pubmed.ncbi.nlm.nih.gov/1511937

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Levels of Plasma Complement Split Products C3a desArg and C5a desArg and their Peripheral Blood Receptors are Elevated in Outpatient Adult Asthmatics with Decreased Asthma Control as Determined by the ACT and ATAQ Questionnaires

Autor: Helen G. Durkin, M. Nowakowski, M.S. Dzhindzhikhashvili, Seto Chice, Rauno Joks, F. Hajee, R. Shams, D.P. Erstein

Publikováno v: Journal of Allergy and Clinical Immunology. 123:S84-S84

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::76f5f6a09353868380bf36c281af7e65
https://doi.org/10.1016/j.jaci.2008.12.294

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Akademický článek

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