Výsledky vyhledávání - "C.William Daggett"

Human complement regulatory proteins protect swine lungs from xenogeneic injury

Autor: Christine L. Lau, Guerard W. Byrne, C.William Daggett, John S. Logan, Jeffrey L. Platt, Mark Yeatman, R. Duane Davis

Publikováno v: The Annals of Thoracic Surgery. 67:769-775

Background . Pulmonary xenotransplantation is not possible because of hyperacute lung injury, the pathogenesis of which is unknown. This study evaluates complement-dependent pathways of pulmonary injury during heterologous perfusion of swine lungs. M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b96922e0cd594459c00d583f208c4cc7
https://doi.org/10.1016/s0003-4975(99)00049-1

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Methylprednisolone reduces the inflammatory response to cardiopulmonary bypass in neonatal piglets: Timing of dose is important

Autor: James Jaggers, C.William Daggett, Paul J. Chai, Ross M. Ungerleider, Andrew J. Lodge

Publikováno v: The Journal of Thoracic and Cardiovascular Surgery. 117:515-522

Introduction: Cardiopulmonary bypass produces an inflammatory response that can cause significant postoperative pulmonary dysfunction and total body edema. This study evaluates the efficacy of preoperative methylprednisolone administration in limitin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef1b298501ab3d26f19a7dae4b5c9f16
https://doi.org/10.1016/s0022-5223(99)70331-4

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Total respiratory support from swine lungs in primate recipients

Autor: Ross M. Ungerleider, C.William Daggett, Jeffrey L. Platt, Edward P. Chen, Carmelo Gullotto, Andrew J. Lodge, Michael M. Frank, Shu S. Linn, R. Duane Davis, Mark Yeatman

Publikováno v: The Journal of Thoracic and Cardiovascular Surgery. 115(1):19-27

The use of nonhuman lung donors, such as swine, has the potential to provide an unlimited supply of organs. However, hyperacute rejection has prevented pulmonary xenotransplantation. Objective: Our aim was to test the hypothesis that immunodepletion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::692cbef0115851dea633edc397c92329

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Swine lungs expressing human complement–regulatory proteins are protected against acute pulmonary dysfunction in a human plasma perfusion model

Autor: Mark Yeatman, C.William Daggett, Andrew J. Lodge, Jeffrey L. Platt, R. Duane Davis, Jeffery H. Lawson, Edward P. Chen, Peter Van Trigt, Guerard W. Byrne, John S. Logan

Publikováno v: The Journal of Thoracic and Cardiovascular Surgery. 113(2):390-398

Pulmonary transplantation is currently limited by the number of suitable cadaver donor lungs. For this reason, pulmonary xenotransplantation is currently being investigated. Objective: Our goal was to assess the role of complement in pulmonary xenogr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3e147bdf1eaa4d9368be72485f24bd4

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Modified ultrafiltration versus conventional ultrafiltration: a randomized prospective study in neonatal piglets

Autor: C.William Daggett, Paul J. Chai, Ross M. Ungerleider, Andrew J. Lodge, John E. Scarborough, James Jaggers

Publikováno v: The Journal of thoracic and cardiovascular surgery. 115(2)

Cardiopulmonary bypass in neonates generates large increases in inflammatory mediators, causing edema formation that may lead to multiple organ dysfunction. Clinical strategies aimed at removing inflammatory mediators, reducing edema formation, and i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be9b2ac84d8b014923af03042f19593a
https://pubmed.ncbi.nlm.nih.gov/9475528

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Regional blood flow during pulsatile cardiopulmonary bypass and after circulatory arrest in an infant model

Autor: Ross M. Ungerleider, Thomas M. Runge, Andrew J. Lodge, C.William Daggett, John H. Calhoon, Akif Ündar

Publikováno v: The Annals of thoracic surgery. 63(5)

Background. Pulsatile perfusion systems have been proposed as a means of improving end-organ perfusion during and after cardiopulmonary bypass. Few attempts have been made to study this issue in an infant model. Methods. Neonatal piglets were subject

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::165669f4694399411f33e7461c4f07e4
https://pubmed.ncbi.nlm.nih.gov/9146309

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The Role Of Endothelial Nitric Oxide Synthase Expression In The Development Of Pulmonary Hypertension In Chronically Hypoxic Infant Swine

Autor: Ross M. Ungerleider, Andrew J. Lodge, C.William Daggett, Samuel E. George, Paul J. Chai, John E. Scarborough, James Jaggers, J.Andrew Williamson

Publikováno v: The Journal of Thoracic and Cardiovascular Surgery. (2):343-350

Objective: Our goal was to determine the role of pulmonary endothelial nitric oxide synthase expression in the development of pulmonary hypertension in infants with congenital cyanotic heart disease. Methods: Two groups of 4-week-old piglets were stu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c67339e5dbb1120a961b26d46d6108e

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