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Detection of platinum-DNA adducts by32P-postlabelling

Autor: F A Blommaert, C.P. Saris

Publikováno v: Nucleic Acids Research. 23:1300-1306

We developed a sensitive 32P-postlabeling method for the detection of bifunctional intrastrand crosslinks d(Pt-GpG) and d(Pt-ApG) in DNA in vitro and in vivo. After enzymatic digestion of DNA the positively charged platinum adducts were purified from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ac7d8ff1a10fba6c0c532e617351e47
https://doi.org/10.1093/nar/23.8.1300

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Repair and replication of plasmids with site-specific 8-oxodG and 8-AAFdG residues in normal and repair-deficient human cells

Autor: H. C. P. F. Roelen, A.J.M. Berns, J. C. Klein, C.P. Saris, M.J. Bleeker, J.G. Westra, H. F. Brugghe, J. H. Van Boom, H. Van Den Elst, E. Kriek, G. A. Van Der Marel

Publikováno v: Nucleic Acids Research. 20:4437-4443

The in vivo mutagenicity of 7-hydro-8-oxo-2'-deoxyguanosine (8-oxodG) and N-(guanin-8-yl)-N-acetyl-2-aminofluorene (8-AAFdG) in human cells was determined by transfecting various cell lines with plasmids that carried a single adduct at a defined site

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7c2831d8e9a93eedaa13ca657473589
https://doi.org/10.1093/nar/20.17.4437

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In vitro formation of DNA adducts by cisplatin, lobaplatin and oxaliplatin in calf thymus DNA in solution and in cultured human cells

Autor: R.C. Rietbroek, C.P. Saris, Pj.M. van de Vaart, Fa. Bloramaert

Publikováno v: Carcinogenesis. 17(12)

Two interesting representatives of a new generation of platinum-based cytostatic drugs that are currently being tested in clinical trials are lobaplatin [1,2-diaminomethylcyclobutane platinum(II) lactate] and oxaliplatin [1,2-diaminocyclohexane plati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75e0e3346bc555d87d18635a577e4626
https://pubmed.ncbi.nlm.nih.gov/9006117

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A 32P-postlabelling assay for the detection of alkylphosphotriesters in DNA

Autor: S.J. Damman, L. Den Engelse, A.M.C.den van Ende, J.G. Westra, C.P. Saris

Publikováno v: Carcinogenesis. 16(7)

Within the group of DNA alkylation products, phosphotriesters (PTE) are among the most stable lesions. Hence, alkyl PTE are attractive biomarkers for DNA alkylation monitoring purposes. We have developed a 32P-postlabelling method for the analysis of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc712d7bb704515dfea0c1b4fc6a3a82
https://pubmed.ncbi.nlm.nih.gov/7614687

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Preparation of the individual diastereomers of adenylyl-(2′-5′)-P-thioadenylyl-(2′-5′)-adenosine and their 5′-phosphorylated derivatives

Autor: C.P. Saris, E. De Vroom, J. H. Van Boom, A. Fidder, G. A. Van Der Marel

Publikováno v: Nucleic Acids Research. 15:9933-9943

The individual diastereomers of trimer A2'p5'A2'p(s)5'A, containing one phosphorothioate linkage, were prepared via a modified hydroxybenzotriazole phosphotriester approach. The 5'-phosphorylated derivatives of the latter compounds were obtained afte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ff87f66acd8af5d16462987a6bb4430
https://doi.org/10.1093/nar/15.23.9933

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Preparation of covalently linked DNA-RNA hybrids and arabinocytidine containing DNA fragments

Autor: C.P. Saris, T.N.W. Budding, H. C. P. F. Roelen, G. A. Van Der Marel, E. De Vroom, J. H. Van Boom

Publikováno v: Nucleic Acids Research. 16:2987-3003

It will be demonstrated that 5'-O-DMT-N-acyl-deoxyribonucleosides, 5'-O-Lev-2'-O-MTHP-N-acyl-ribonucleosides and, also, 2'-O-MTHP-N-acyl-ara-cytidine can be coupled, via the hydroxybenzotriazole phosphotriester approach, to afford two types of DNA-RN

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f556aca1d00f7a295147cc099cca8ed
https://doi.org/10.1093/nar/16.7.2987

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