Zobrazeno 1 - 10
of 28
pro vyhledávání: '"C.O. Starnes"'
Autor:
L. Munyakazi, Qiao Yan, B. Wiemann, C. Matheson, Gwyneth Van, S. Ogenstad, Dimitry M. Danilenko, C.O. Starnes
Publikováno v:
Experimental neurology. 149(2)
Experimental autoimmune encephalomyelitis (EAE) is a term given to describe a collection of animal models representing the human disease multiple sclerosis (MS). Although not fully understood, the involvement of cytokines and the immune system in eit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36e1007ce34a44573badfbcafd344c28
https://pubmed.ncbi.nlm.nih.gov/9500957
https://pubmed.ncbi.nlm.nih.gov/9500957
Autor:
Patty Wisian-Neilson, F. Harchelroad, M.K. Das, Iris H. Hall, Bernard F. Spielvogel, Andrew T. McPhail, C.O. Starnes
Publikováno v:
Journal of Pharmaceutical Sciences. 69:1025-1029
Amine cyanoboranes and amine carboxyboranes (boron analogs of α -amino acids) were shown to inhibit inflammation. The analogs effectively blocked general inflammation, induced arthritis, and the writhing reflex associated with inflammation pain, whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68572e30c47d68e108c66a69d7b7cd7f
https://doi.org/10.1002/jps.2600690912
https://doi.org/10.1002/jps.2600690912
Publikováno v:
Journal of Medicinal Chemistry. 20:333-337
Evidence is presented that sesquiterpene lactones or ketones containing the O=CC=CH2 moiety, e.g., tenulin and helenalin, alkylate the thiol group of reduced glutathione and L-cysteine in vitro. A proposal is offered that this mechanism of action is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5b5c8c1d0b7d7ce984aa632edcf57c8
https://doi.org/10.1021/jm00213a003
https://doi.org/10.1021/jm00213a003
Autor:
Eng Chun Mar, Salwa A. Elgebaly, Ivonne Weidner, Robert I. Hadgraft, Thomas G. Waddell, Iris H. Hall, Charles G. Ruffner, C.O. Starnes, Kuo Hsiung Lee
Publikováno v:
Science. 196:533-536
Helenalin and tenulin injected into CF1 male mice bearing Ehrlich ascites tumors inhibit DNA synthesis and DNA polymerase enzymatic activity in the tumor cells. Helenalin inhibited protein synthesis. Both drugs increased the concentration of adenosin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8a9b0744cc685bd90171d86b0abd619
https://doi.org/10.1126/science.191909
https://doi.org/10.1126/science.191909
Publikováno v:
Chemischer Informationsdienst. 8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9393fad3c8c7a69ec5262b9e412b1c83
https://doi.org/10.1002/chin.197730177
https://doi.org/10.1002/chin.197730177
Autor:
F. Jun. Harchelroad, B. F. Spielvogel, Patty Wisian-Neilson, C.O. Starnes, Andrew T. McPhail, M. K. Das, I. H. Hall
Publikováno v:
Chemischer Informationsdienst. 12
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62a25dbee032f01f8a5ddc89a9d5183d
https://doi.org/10.1002/chin.198110289
https://doi.org/10.1002/chin.198110289
Autor:
Rong-Yang Wu, Y. Sumida, J.W. Cochran, C.O. Starnes, Thomas G. Waddell, K.G. Gerhart, Iris H. Hall, K.H. Lee
Publikováno v:
Journal of pharmaceutical sciences. 68(5)
Some sesquiterpene lactones and related compounds were tested for anti-inflammatory activity in rodents. In the edema-induced carrageenan inflammation screen, the alpha-methylene-gamma-lactone moiety of the sesquiterpene lactones was required for inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49a5f9f204879a6cf36395141f882170
https://pubmed.ncbi.nlm.nih.gov/311831
https://pubmed.ncbi.nlm.nih.gov/311831
Publikováno v:
Journal of pharmaceutical sciences. 69(5)
Sesquiterpene lactones containing an α-methylene-γ-lactone moiety were shown to be potent inhibitors of carrageenan-induced edema and chronic adjuvant-induced arthritis in rodents at 2.5 mg/kg/day. The mode of action of sesquiterpene lactones as an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bb97a6e6171a8f19e81dac4b1ed33e9
https://pubmed.ncbi.nlm.nih.gov/6247478
https://pubmed.ncbi.nlm.nih.gov/6247478
Publikováno v:
Journal of pharmaceutical sciences. 69(6)
Some naturally occurring pseudoguaianolides and germacranolides as well as synthetic related compounds were observed to be antihyperlipidemic agents in mice. Several of these compounds at a dose of 20 mg/kg/day resulted in lowering of serum cholester
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1df9dc59aa13ff8aa00c6c92d565cfa2
https://pubmed.ncbi.nlm.nih.gov/7205585
https://pubmed.ncbi.nlm.nih.gov/7205585
Publikováno v:
Journal of pharmaceutical sciences. 68(6)
Several newly synthesized boron betaine analogs had anti-tumor activity in Ehrlich ascites, Walker 256 ascites carcinosarcoma, and Lewis lung screens and marginal activity in the B-16 melanotic melanoma screen. In vivo testing demonstrated that trime
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0af2b4031ddcb178a75dd81730dc41ea
https://pubmed.ncbi.nlm.nih.gov/222887
https://pubmed.ncbi.nlm.nih.gov/222887