Zobrazeno 1 - 3
of 3
pro vyhledávání: '"C.Nicholas Hodge"'
Autor:
George V. De Lucca, Wayne F. Daneker, Paul E. Aldrich, Y. Ru, C.-H. Chang, Charles J. Eyermann, C.Nicholas Hodge, Edward R. Holler, Francis J. Woerner, and Joseph C. Calabrese, Robert F. Kaltenbach, Fernandez Ch, Prabhakar K. Jadhav, Patrick Y.S. Lam, George Emmett
Publikováno v:
Journal of the American Chemical Society. 120:4570-4581
One important factor influencing the affinity of a flexible ligand for a receptor is the internal strain energy required to attain the bound conformation. Calculation of fully equilibrated ensembles of bound and free ligand and receptor conformations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f445c4e3755bdb4b9da6a68a7cfc8435
https://doi.org/10.1021/ja972357h
https://doi.org/10.1021/ja972357h
Autor:
C.Nicholas Hodge, John Pierce
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:1605-1608
4-aminoquinazoline II is a fully functional substitute for salicylamide I as a competitive inhibitor of scytalone dehydratase. Kinetic measurements demonstrate that both inhibitors bind to the enzyme in their neutral form, suggesting that the hydroge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ebcbdaaa13d66910a7922e64e9af82a
https://doi.org/10.1016/s0960-894x(00)80026-8
https://doi.org/10.1016/s0960-894x(00)80026-8
Publikováno v:
Analytical biochemistry. 256(1)
We have synthesized an alternate substrate for trihydroxynaphthalene reductase (3HNR) and scytalone dehydratase (SD), two enzymes in the fungal melanin biosynthetic pathway. The oxidation of 2,3-dihydro-2,5-dihydroxy-4 H -benzopyran-4-one (DDBO) to 4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2129843aa70d9fa77d37f217982425be
https://pubmed.ncbi.nlm.nih.gov/9466791
https://pubmed.ncbi.nlm.nih.gov/9466791