Synthesis optimization of 2-(4-N-[11C]methylaminophenyl)-6-hydroxybenzothiazole ([11C]PIB), ?-amyloid PET imaging tracer for Alzheimer's disease diagnosis

Autor: A.Coliva a, C.Monterisi b, A.Apollaro b, D.Gatti c, M.Penso d, L.Gianolli c, D.Perani a, b, M.C. Gilardi b, c, A.Carpinelli b

Publikováno v: Applied radiation and isotopes 105 (2015): 66–71. doi:10.1016/j.apradiso.2015.07.003
info:cnr-pdr/source/autori:A.Coliva a, C.Monterisi b, A.Apollaro b, D.Gatti c, M.Penso d, L.Gianolli c, D.Perani a,b, M.C. Gilardi b,c, A.Carpinelli b,c/titolo:Synthesis optimization of 2-(4-N-[11C]methylaminophenyl)-6-hydroxybenzothiazole ([11C]PIB), ?-amyloid PET imaging tracer for Alzheimer's disease diagnosis./doi:10.1016%2Fj.apradiso.2015.07.003/rivista:Applied radiation and isotopes/anno:2015/pagina_da:66/pagina_a:71/intervallo_pagine:66–71/volume:105

[11C]PIB is the most used amyloid plaques-specific positron-emitting radiotracers. The radiosynthesis of this compound, carried out by methylation of its precursor with [11C]methyl triflate in 2-butanone, has been improved optimizing the initial conc

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http://www.cnr.it/prodotto/i/333701