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Akademický článek
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Autor:
Gregg D. Cappon, Mark E. Hurtt, David M. Potter, C.M. Luetjens, Christopher J. Bowman, Gerhard F. Weinbauer
Publikováno v:
Reproductive Toxicology. 41:67-72
To determine the sensitivity of male reproductive toxicity endpoints in NHPs we performed a power analysis of routine and triggered endpoints using control data from sexually mature Asian and Mauritian NHPs. The power to detect a 50% change from cont
Autor:
Gerhard F. Weinbauer, C.M. Luetjens
Publikováno v:
Regulatory Toxicology and Pharmacology. 63:391-400
Selection of suitable criteria for assessing sexual maturity in the male long-tailed macaque (Macaca fascicularis) has yielded conflicting results. The present retrospective work investigates whether the sole presence of sperm in the baseline semen s
Autor:
C.M. Luetjens, Ramona Wesselmann
Publikováno v:
Journal of Medical Primatology. 37:128-140
Background Sperm-derived mitochondria are integrated into the oocyte at fertilization but seem to vanish during the early cleavage phase. The developmental potential of pre-implantation embryos seems to be closely related to their ability to induce d
Publikováno v:
Journal of Medical Primatology. 36:21-24
Background The present communication reports intravesical semen coagulation and formation of a larger precipitate in two Cynomolgus monkeys. Methods Ultrasound of the urinary bladder and light microscopy of intravesical coagulates. Results These monk
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 73(2)
Assessment of learning ability in nonhuman primate (NHP) models is sometimes requested by regulatory authorities. The double choice object discrimination task using a Wisconsin General Testing Apparatus (WGTA) approach is typically being applied. In
Publikováno v:
MHR: Basic science of reproductive medicine. 13:85-93
The complex process of spermatogenesis requires the expression and precise coordination of a multitude of genes. Abnormal function of such genes is frequently associated with male infertility. Among these candidates is the human BOULE gene that is a
Publikováno v:
Human Reproduction. 20:1248-1255
BACKGROUND Gonosomal aneuploidies such as Klinefelter syndrome (47,XXY) are the most frequent chromosomal aberration in infertile men. Normally the chromosomal status of patients is detected by karyotyping of up to 20 metaphase spreads of lymphocyte
Publikováno v:
Biology of Reproduction. 72:293-300
The present study examines the existence of clonogenic patterns in the proliferation and differentiation of spermatogonial stem cells in two species of non-human primates, the marmoset and the rhesus monkey. We developed a novel approach to detect pr