Zobrazeno 1 - 10
of 28
pro vyhledávání: '"C.M. Dreef-Tromp"'
Autor:
C.M. Dreef-Tromp, Jan E. M. Basten, C. A. A. Van Boeckel, M.A. Broekhoven, Petitou Maurice, T. G. Van Dinther
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 8:2081-2086
The in vitro antithrombotic activity of synthetic glycoconjugates I and II, comprising a flexible polyethylene glycol type and a rigid polyglucose type spacer, respectively, are compared to heparin.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d678228099851aff9ec3a8f0eaf8ebfd
https://doi.org/10.1016/s0960-894x(98)00382-5
https://doi.org/10.1016/s0960-894x(98)00382-5
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:1175-1180
The polyethylene glycol (PEG-polymer)-supported solution synthesis of heparan sulphate-like oligomers, which differ in length (up till 12-mers) and sulphation pattern, is described.1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::637555c4d78338be9ec7b2c1435c9fd1
https://doi.org/10.1016/s0960-894x(97)00183-2
https://doi.org/10.1016/s0960-894x(97)00183-2
Publikováno v:
Synthesis. 1992:1269-1272
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad0a031d101d9513dff54dcdfa9f03c9
https://doi.org/10.1055/s-1992-26355
https://doi.org/10.1055/s-1992-26355
Publikováno v:
Tetrahedron Letters. 32:6637-6640
Condensation of protected β-benzyl-aspartate 4 with 2-amino-ethanol, subsequent deprotection of the amino function and coupling with N , N′ -di-benzyloxycarbonyl-lysine ( 7 ) afforded the peptidyl alcohol 8 . Glycosylation of methyl 3,4,6 tri- O -
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a3814dbcc37b57f92c149d1ae6e15bb
https://doi.org/10.1016/0040-4039(91)80242-x
https://doi.org/10.1016/0040-4039(91)80242-x
Publikováno v:
Nucleic Acids Research. 18:6491-6495
The preparation of the nucleopeptide H-Phe-Tyr-(pATAT)-NH2 could be realized via a solid phase phosphitetriester approach and by using the protected protecting group 2-(tert-butyldiphenylsilyoxymethyl)-benzoyl for the masking of the N6-amino function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba32437cb4ddc39f3e09f81e63730612
https://doi.org/10.1093/nar/18.22.6491
https://doi.org/10.1093/nar/18.22.6491
Publikováno v:
Tetrahedron Letters. 31:427-430
2-( Tert -butyldiphenylsilyloxymethyl)benzoyl chloride (SiOMB-Cl) reacts with the per-O-trimethylsilylated d-nucleosides C,G and A to give, after removal of the Si(Me) 3 groups and 5'-O-protection with 4,4'-dimethoxytrityl chloride (DMT-Cl), the corr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36f6ca3e692909104fb27fd937d71959
https://doi.org/10.1016/s0040-4039(00)94573-8
https://doi.org/10.1016/s0040-4039(00)94573-8
Autor:
Rogier C. Buijsman, C.M. Dreef-Tromp, Constant A. A. van Boeckel, Jan E. M. Basten, Jacques H. van Boom, Gijsbert A. van der Marel
Publikováno v:
Bioorganicmedicinal chemistry. 7(9)
The synthesis of three heparin analogues (i.e. compounds VI-VIII) having perphosphorylated thrombin binding domains (TBDs) is reported. These compounds were tested in vitro for their antithrombin III (ATIII)-mediated anti-Xa and antithrombin activiti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27c7efb1999520cd47e1ab88e3320d52
https://pubmed.ncbi.nlm.nih.gov/10530936
https://pubmed.ncbi.nlm.nih.gov/10530936
Publikováno v:
Bioorganicmedicinal chemistry letters. 8(10)
The syntheses of several heparin-like glycoconjugates (i.e., 16a-f) containing identical AT III binding domains (ABD) and spacers but different thrombin binding domains (TBDs) are described. Biological activities of conjugates 16a-f indicate that the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7be9103527fa88994f6337d7609481b4
https://pubmed.ncbi.nlm.nih.gov/9871735
https://pubmed.ncbi.nlm.nih.gov/9871735
Autor:
C. A. A. Van Boeckel, R. G. M. Van Amsterdam, P. Westerduin, Peter D. J. Grootenhuis, D.G. Meuleman, Jan E. M. Basten, C.M. Dreef-Tromp
The natural product heparin is an important lead in research on antithrombotics. By molecular modification of a unique heparin fragment new derivatives were discovered. One of them, the synthetic counterpart of the antithrombin III binding pentasacch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f889721f9b3af42cd5f01750c6074fa0
https://doi.org/10.1016/s0165-7208(97)80088-8
https://doi.org/10.1016/s0165-7208(97)80088-8
