Zobrazeno 1 - 10
of 42
pro vyhledávání: '"C.M. Arbeeny"'
Autor:
Liesl G. Fisher, P.J. McCann, D.A. Young, C.M. Arbeeny, S. Skwish, Amarendra B. Mikkilineni, Poss Kathleen M, G.T. Allen, Chongqing Sun, Michael Cap, R.J. George, Dorothy Slusarchyk, B.E. Abboa-Offei, Ravindar N. Girotra, William N. Washburn, Carl P. Ciosek, A.V. Gavai, Belay Tesfamariam, T.W. Harper, Ginger Wu, B.H. Frohlich, D.E. Hillyer, Tammy C. Wang, A A Seymour, Mark S. Bednarz, Philip M. Sher, Kenneth E.J. Dickinson, T.L. Waldron, Arvind Mathur
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:3041-3044
A series of 4-hydroxy-3-methylsulfonanilido-1,2-diarylethylamines were prepared and evaluated for their human beta(3) adrenergic receptor agonist activity. SAR studies led to the identification of BMS-196085 (25), a potent beta(3) full agonist (K(i)=
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fa60fae9d49d33984476839ff530ef2
https://doi.org/10.1016/s0960-894x(01)00629-1
https://doi.org/10.1016/s0960-894x(01)00629-1
Autor:
Douglas Young, Michael Cap, Olga M. Fryszman, Thomas J. Maccagnan, Mujing Yan, John R. Wetterau, Prakash Taunk, Shih-Jung Lan, Richard B. Sulsky, Michael A. Poss, William A. Slusarchyk, Fergal Connolly, Jeffrey A. Robl, Joseph A. Tino, Kern G. Jolibois, R.J. George, Beverly Ricci, Scott A. Biller, David R. Magnin, Janette V. H. Logan, Thomas Harrity, Lori Kunselman, Ying Chen, R. Michael Lawrence, Jamil Haris, C.M. Arbeeny, John K. Dickson, Christa L. Musial, Ligaya M. Simpkins, Ching-Hsuen Chu, David A. Gordon, Richard E. Gregg
Publikováno v:
Science. 282:751-754
Patients with abetalipoproteinemia, a disease caused by defects in the microsomal triglyceride transfer protein (MTP), do not produce apolipoprotein B–containing lipoproteins. It was hypothesized that small molecule inhibitors of MTP would prevent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f88149a4ec618ecbdd85e890aa9d71a
https://doi.org/10.1126/science.282.5389.751
https://doi.org/10.1126/science.282.5389.751
Autor:
David A. Gordon, C.M. Arbeeny, John R. Wetterau, Marie C. M. Lin, Bernadette Kienzle, K Bergquist
Publikováno v:
Journal of Biological Chemistry. 269:29138-29145
Microsomal triglyceride transfer protein (MTP) is a heterodimer consisting of protein disulfide isomerase and a unique large subunit. Recent studies showing that an absence of MTP is a cause of abetalipoproteinemia indicate that MTP is required for t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3646704ea11e38d7b0c24fe0c776502e
https://doi.org/10.1016/s0021-9258(19)62022-3
https://doi.org/10.1016/s0021-9258(19)62022-3
Publikováno v:
Journal of Lipid Research, Vol 33, Iss 6, Pp 843-851 (1992)
The hamster was developed as a model to study very low density lipoprotein (VLDL) metabolism, since, as is the case in humans, the hamster liver was found to synthesize apoB-100 and not apoB-48. The effect of inhibiting fatty acid synthesis on the he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::865971b9948ca0ee457af1af2cecb21a
https://doi.org/10.1016/s0022-2275(20)41509-3
https://doi.org/10.1016/s0022-2275(20)41509-3
Autor:
Z. Merchant, S. Skwish, Dorothy Slusarchyk, P.J. McCann, D.A. Young, M. Morella, Kenneth E.J. Dickinson, Michael Cap, Ravindar N. Girotra, Anita D. Russell, B.E. Abboa-Offei, William N. Washburn, G.T. Allen, A.V. Gavai, Belay Tesfamariam, Peter T. W. Cheng, G. S. Bisacchi, Tammy C. Wang, A A Seymour, T.W. Harper, C.M. Arbeeny, Tamara Dejneka, Amarendra B. Mikkilineni, Poss Kathleen M, Chongqing Sun, Philip M. Sher, T.L. Waldron, R.J. George, B.H. Frohlich, Ginger Wu, Denis E. Ryono
Publikováno v:
Bioorganicmedicinal chemistry letters. 14(13)
A series of N-(4-hydroxy-3-methylsulfonanilidoethanol)arylglycinamides were prepared and evaluated for their human β3 adrenergic receptor agonist activity. SAR studies led to the identification of BMS-201620 (39), a potent β3 full agonist (Ki=93 nM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c4e6c1a53153c8278f43697b1fe4710
https://pubmed.ncbi.nlm.nih.gov/15177466
https://pubmed.ncbi.nlm.nih.gov/15177466
Publikováno v:
The Journal of clinical endocrinology and metabolism. 82(2)
Primary adipocytes were isolated from axillary brown adipose tissue from adult cynomolgus monkeys. That this tissue contained brown adipocytes was verified by morphological examination and by demonstrating the presence of uncoupling protein messenger
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::960abeacfb49be52ca6a842a9bb3a674
https://pubmed.ncbi.nlm.nih.gov/9024225
https://pubmed.ncbi.nlm.nih.gov/9024225
Autor:
Donna Hillyer, Stephen S. Kalinowski, Karen S. Brown, Narayanan Hariharan, Allison Treloar, C.M. Arbeeny, Kasim A. Mookhtiar, Dennis Farrelly, Deborah Hagan, Talal Sabrah
Publikováno v:
Diabetes. 46(1)
Glucokinase is the predominant hexokinase in pancreatic β-cells and liver parenchymal cells and functions as a critical component of the glucose-sensing apparatus in these glucose-responsive cell types. In the β-cells, the sensing leads to insulin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05ba9f7fcf249c1b4771140a8caab11b
https://pubmed.ncbi.nlm.nih.gov/8971074
https://pubmed.ncbi.nlm.nih.gov/8971074
Publikováno v:
The American journal of physiology. 268(4 Pt 1)
Treatment of obese (ob/ob) mice with the beta 3-adrenergic receptor (beta 3-AR) agonist BRL-35135 (1 mg.kg body wt-1.day-1 for 20 days) normalized plasma glucose levels and significantly decreased plasma insulin and nonesterified fatty acid levels. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::783fb8c2cf3ec56686a6669cef4bf324
https://pubmed.ncbi.nlm.nih.gov/7733267
https://pubmed.ncbi.nlm.nih.gov/7733267
Publikováno v:
Biochimica et biophysica acta. 1083(3)
Experiments were performed to characterize plasma lipid transfer protein activity (LTA), and the rate of [3H]CE transfer from HDL to lower density lipoproteins in plasma of hamsters. Compared to rabbits, hamster plasma has about one-tenth the level o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc42c4f4cdb00454309af3af0f8525aa
https://pubmed.ncbi.nlm.nih.gov/2049390
https://pubmed.ncbi.nlm.nih.gov/2049390
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