Zobrazeno 1 - 5
of 5
pro vyhledávání: '"C.Lee Wright"'
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 44:409-420
The design and syntheses of androstenedione derivatives with bridges spanning the 2,19-, 3,19-, 4,19- and 6,19-positions are described. 2,19-Bridged compounds bearing hydroxyl groups on the two-carbon bridge ( 3a and 3b ) were designed as stable carb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbf12f50770a9464926bd0ced5089170
https://doi.org/10.1016/0960-0760(93)90244-q
https://doi.org/10.1016/0960-0760(93)90244-q
Publikováno v:
Steroids. 56:180-184
Liver cytochrome P450 monooxygenases (P450), a group of isozymes that catalyze the reductive cleavage of molecular oxygen, dominate hepatic metabolism of xenobiotic lipophilic substances. These P450 enzymes exhibit broad and overlapping substrate spe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7becc8a699c20133e54dfb3ce06e09cb
https://doi.org/10.1016/0039-128x(91)90079-b
https://doi.org/10.1016/0039-128x(91)90079-b
Publikováno v:
The Journal of steroid biochemistry and molecular biology. 44(4-6)
Hydroxylated 2,19-methylene-bridged androstenediones were designed as potential mimics of enzyme oxidized intermediates of androstenedione. These compounds exhibited competitive inhibition with low micromolar affinities for aromatase. These inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a7840907fb7362e59143ad47a3a2ba3
https://pubmed.ncbi.nlm.nih.gov/8476773
https://pubmed.ncbi.nlm.nih.gov/8476773
Publikováno v:
The Journal of steroid biochemistry and molecular biology. 42(3-4)
Metabolism of 11-deoxycorticosterone (DOC) by hamster adrenal mitochondria gives 19-hydroxy-DOC and corticosterone (via 11-hydroxylation) in approximately equal yields. The ratio of 19- to 11-hydroxylation was invariant with changes in concentration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0ec2a16c4e3f187dd90dff024fb5b30
https://pubmed.ncbi.nlm.nih.gov/1606048
https://pubmed.ncbi.nlm.nih.gov/1606048
Publikováno v:
Steroids. 45:357-374
Androst-4-en-3-one analogs incorporating a trimethylsilyl or a trimethylsilylmethyl group at C-1, C-2 or C-19 were prepared and evaluated as inhibitors of aromatase. Only 10-[1-hydroxy-2-(trimethylsilyl)ethyl]estr-4-ene-3,17-dione inhibited human pla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6637af32cfb29b5c24dd3f252bfac59
https://doi.org/10.1016/0039-128x(85)90084-4
https://doi.org/10.1016/0039-128x(85)90084-4