Zobrazeno 1 - 10
of 156
pro vyhledávání: '"C.K. Atterwill"'
Publikováno v:
Neuropharmacology. 225
Research on classical psychedelics (psilocybin, LSD and DMT) and entactogen, MDMA, has produced a renaissance in the search for more effective drugs to treat psychiatric, neurological and various peripheral disorders. Psychedelics and entactogens act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a55448737acfcecaf50140200c6fae71
https://pubmed.ncbi.nlm.nih.gov/36529260
https://pubmed.ncbi.nlm.nih.gov/36529260
Publikováno v:
Cell Biology and Toxicology. 15:137-142
Rat whole-brain spheroids were used to assess the intrinsic neurotoxicity of methylenedioxymethamphetamine (MDMA, Ecstasy) and two of its metabolites, dihydroxymethamphetamine (DHMA) and 6-hydroxy-MDMA (6-OH MDMA). Exposure of brain spheroids to MDMA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9d5b92a383f6eb37f58eb755d3cb3c4
https://doi.org/10.1023/a:1007658501306
https://doi.org/10.1023/a:1007658501306
Autor:
C.K Atterwill, M.G Wing
Publikováno v:
Encyclopedia of Pharmaceutical Science and Technology, Fourth Edition ISBN: 9781841848204
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16b32581c7a42fbfc3c988a6e07a56f4
https://doi.org/10.1081/e-ept4-120019307
https://doi.org/10.1081/e-ept4-120019307
Publikováno v:
Human & Experimental Toxicology. 14:469-474
1 A class of compounds, 9-aminoacridines, have long been known to be reversible inhibitors of acetyl cholinesterase (AChE - EC 3.1.1.7), the most familiar of which is 9-amino-1,2,3,4-tetrahydroacridine (Tacrine). 2 A novel aminoacridine was synthesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::748e3fd81c6e12f2ac094e5b11184981
https://doi.org/10.1177/096032719501400601
https://doi.org/10.1177/096032719501400601
Autor:
C.K. Atterwill, Wendy M. Purcell
Publikováno v:
Neurochemical Research. 20:521-532
Mast cells are located in close proximity to neurons in the peripheral and central nervous systems, suggesting a functional role in normal and aberrant neurodegenerative states. They also possess many of the features of neurons, in terms of monoamine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7acaf9d7cc46e702716981eedcb31fb8
https://doi.org/10.1007/bf01694534
https://doi.org/10.1007/bf01694534
Autor:
C.K. Atterwill, Wendy M. Purcell
Publikováno v:
Toxicology in Vitro. 8:627-630
Mast cells derived from rodent or human tissues, either by direct lavage or following enzymic dispersal, secrete biogenic amines on challenge with a range of xenobiotics. In addition to synthetic pathways, re-uptake systems and metabolizing enzymes f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd827ab342e4c1a9a22395a93ed14f75
https://doi.org/10.1016/0887-2333(94)90031-0
https://doi.org/10.1016/0887-2333(94)90031-0
Autor:
S.P. Williams, S. O'Hare, M.R. Cookson, C.K. Atterwill, Michael J. Garle, V.W. Pentreath, R. McClean, C. Egan, J. Davenport-Jones
Publikováno v:
Toxicology in Vitro. 8:799-802
In the absence of a formal in vitro alternative model for neurotoxicity testing, the CellTox Centre, in collaboration with the University of Salford, FRAME and the EEC, has set up an initial pre-validation trial of a three-tiered scheme that was orig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54a57348a1f521b784d877b1cbbcea6b
https://doi.org/10.1016/0887-2333(94)90071-x
https://doi.org/10.1016/0887-2333(94)90071-x
Autor:
C.K. Atterwill, W.M. Purcell
Publikováno v:
Human & Experimental Toxicology. 13:429-433
1 In both the developing and adult nervous systems, nerve growth factor (NGF) influences neuronal survival, differentiation and recovery following insult, 2 The effect of NGF upon human placental mast cells (HPMC) was investigated, since it is known
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4cc34521604111131b70efacafdfc08
https://doi.org/10.1177/096032719401300611
https://doi.org/10.1177/096032719401300611
Publikováno v:
Toxicology in Vitro. 8:309-316
Toxicological studies in the rat with phenobarbital and temelastine (SKF 93944) are associated with thyroid lesions, characterized by thyroid stimulated hormone-mediated thyroid follicular cell hypertrophy and hyperplasia. It has previously been demo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b338a43eee94af146f256930f216cba
https://doi.org/10.1016/0887-2333(94)90151-1
https://doi.org/10.1016/0887-2333(94)90151-1
Autor:
Wendy M. Purcell, S. Goonetilleke, J. Davenport-Jones, S.M. Thomas, H.B. Johnston, M. West, S.P. Williams, C.K. Atterwill
Publikováno v:
Toxicology in Vitro. 7:569-580
Many cell culture models are available for the in vitro assessment of neurotoxicity. The use of three culture types has been investigated: neuroblastoma cell lines, primary cultures of rat and chick midbrain, and organotypic whole brain reaggregate c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b8f33bb320a2275ee81a8f5c893c23d
https://doi.org/10.1016/0887-2333(93)90090-r
https://doi.org/10.1016/0887-2333(93)90090-r