Zobrazeno 1 - 10 of 15 pro vyhledávání: '"C.J.T. Hoes"'
1
Synthesis and biodistribution of immunoconjugates of a human IgM and polymeric drug carriers
Autor: P.J. Boon, E.S. Bos, M. Winters, F. Kaspersen, Jan Feijen, C.J.T. Hoes, P. Loeffen, J. Grootoonk, I. Schlachter
Publikováno v: Journal of controlled release, 19(1-3), 59-76. Elsevier
The synthesis and purification of radiolabelled immunoconjugates, composed of a human IgM monoclonal antibody directed against an intracellular tumour-associated antigen and either poly (alpha-L-glutamic acid) (PGA) or poly[N5-(2-hydroxyethyl)-L-glut
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::380dc56bce4748603dd6b1666e0d6025
https://doi.org/10.1016/0168-3659(92)90065-y
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2
Synthesis and biological evaluation of immunoconjugates of adriamycin and a human IgM linked by poly[N5-(2-hydroxyethyl)-l-glutamine
Autor: I. Schlachter, Martinus J.K. Ankone, A. van Doornmalen, D. Pham, Jan Feijen, C.J.T. Hoes, P.J. Boon, E Bos, E. van der Struik, A. van Ettekoven, Frans M. Kaspersen, J. Grootoonk, A. de Man
Publikováno v: Journal of controlled release, 38(38), 245-266. Elsevier
The synthesis and purification of radiolabelled immunoconjugates, composed of a human IgM monoclonal antibody (IgM 16.88) directed against an intracellular tumour-associated antigen, the drug carrier poly[N5-(2-hydroxyethyl)--glutamine] (PHEG) and th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::385581137b76d56e7b8bf6696464763c
https://research.utwente.nl/en/publications/8bf546e3-7e72-4496-b27c-cf92c9a42ba3
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3
Design of soluble conjugates of biodegradable polymeric carriers and adriamycin
Autor: E.S. Bos, C.J.T. Hoes, F. Kaspersen, P.J. Boon, Jan Feijen
Publikováno v: Makromolekulare Chemie. Macromolecular symposia, 70-(71), 119-136. Wiley-VCH Verlag
To improve the therapeutic index of the cytostatic drug adriamycin (ADR), conjugates of ADR with poly(α-L-glutamic acid) (PGA), poly[N5-(2-hydroxyethyl)-L-glutamine] (PHEG) and conjugates of polymer-bound ADR and a human monoclonal antibody directed
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfc58f007e1db96c30df1e05cfd09a5b
https://research.utwente.nl/en/publications/55daf907-08ee-4c7d-aa08-4feeb47eae3d
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4
Biological properties of adriamycin bound to biodegradable polymeric carriers
Autor: J. Grootoonk, Ruth Duncan, Jan Feijen, M. Bhakoo, I.C. Hume, J.M.W. Bouma, C.J.T. Hoes
Publikováno v: Journal of controlled release, 23(23), 37-54. Elsevier
Journal of Controlled Release, 23(1), 37-54. Elsevier Bedrijfsinformatie b.v.
Three different conjugates having adriamycin (ADR) bound to the side chain carboxyl groups of high-molecular weight poly (?--glutamic acid) (PGA) either directly or by interpolation of GlyGly and GlyGlyGlyLeu spacers, respectively, were compared with
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42b3e7d5b2cd6247db4214f153373698
https://research.utwente.nl/en/publications/7c470f0c-25cc-4a29-9eee-95899a5429ca
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5
Biodegradable polymeric prodrugs of naltrexone
Autor: Sung Wan Kim, Xiaoling Li, D.B. Bennet, Adams Nathan William, Jan Feijen, C.J.T. Hoes
Publikováno v: Journal of controlled release, 16(1-2), 43-52. Elsevier
The development of a biodegradable polymeric drug delivery system for the narcotic antagonist naltrexone may improve patient compliance in the treatment of opiate addiction. Random copolymers consisting of the α-amino acids N5-(3-hydroxypropyl-l-glu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::330e20c811ded2956075b5d81ebdd61f
https://research.utwente.nl/en/publications/5ac97ba3-feb7-4983-bf08-50c0a14aa4d1
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6
The synthesis and characterization of polypeptide-adriamycin conjugates and its complexes with adriamycin
Autor: M.J.D. Eenink, W. Potman, W.A.R. Heeswijk, T. Stoffer, Jan Feijen, C.J.T. Hoes
Publikováno v: Journal of controlled release, 1(4), 301-315. Elsevier
Poly(α-l-glutamic acid) (PGA) was grafted with amino acid and oligopeptide spacers up to 5 amino acids with the use of N,N'-carbonyldiimidazole and 2,3-dihydro-1,2-benz-isothiazole-3-on-1, 1-dioxide (saccharin) as an additive, and these polypeptides
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d1d31f897b94e37a0fe45bfc6a964c0
https://doi.org/10.1016/0168-3659(85)90006-9
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8
Optimization of macromolecular prodrugs of the antitumor antibiotic adriamycin
Autor: J. Mud, W.A.R. Heeswijk, W. Potman, B.G. de Grooth, Jan Feijen, Jan Greve, C.J.T. Hoes
Publikováno v: Journal of controlled release, 2, 205-213. Elsevier
In our earlier work [10] on aminoribosyl-bound prodrugs of adriamycin (ADR) using poly(α-l-glutamic acid) (PGA) grafted in high yield (90–100 mol.%) with various peptide spacers as a plasma-soluble macromolecular carrier we observed rather low cyt
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63757c1cd29beeee3aed980c8050fbd4
https://research.utwente.nl/en/publications/1bc0051d-177c-42c0-bb8c-362dbc59040c
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9
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10
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