Zobrazeno 1 - 10
of 72
pro vyhledávání: '"C.J. Vardey"'
Publikováno v:
British Journal of Pharmacology. 123:1009-1015
1. The long-acting beta2-adrenoceptor agonist, salmeterol (10(-9)-10(-5) M), inhibited the IgE-mediated release of histamine from human lung mast cells (HLMC) in a dose-dependent fashion. Additional beta-adrenoceptor agonists were studied and the ran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82a6b1860d140dd896303b4db5e89cf2
https://doi.org/10.1038/sj.bjp.0701703
https://doi.org/10.1038/sj.bjp.0701703
Publikováno v:
British Journal of Pharmacology. 120:961-967
To investigate further the mechanism of the long duration of action of the selective β2-adrenoceptor agonist, salmeterol, we have determined the duration of action of some responses to salmeterol which are not mediated throughβ2-adrenoceptors. In t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c390c298489f14fd9543c85afcb4685
https://doi.org/10.1038/sj.bjp.0700986
https://doi.org/10.1038/sj.bjp.0700986
Publikováno v:
British Journal of Pharmacology. 114:1459-1465
1. The aims of this study were to characterize the EP receptor subtype mediating the inhibition of superoxide anion generation by formyl methionyl leucine phenylalanine (FMLP)-stimulated human neutrophils, and to test the hypothesis that adenosine 3'
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44eb1cb3364f457c9262365f4c07e10b
https://doi.org/10.1111/j.1476-5381.1995.tb13370.x
https://doi.org/10.1111/j.1476-5381.1995.tb13370.x
Publikováno v:
British Journal of Pharmacology. 110:1112-1116
1. We have investigated the potency and duration of action of isoprenaline and a range of beta-adrenoceptor agonists as relaxants of inherent tone in human superfused, isolated bronchial smooth muscle, a tissue reported to contain a homogeneous popul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db196bb626bddc8f5b8f59e3e5f268f1
https://doi.org/10.1111/j.1476-5381.1993.tb13929.x
https://doi.org/10.1111/j.1476-5381.1993.tb13929.x
Autor:
Susan J. Sparrow, Anthony T. Nials, Malcolm Thomas, R.A. Coleman, Gillian D. Shepherd, Lois H. Denyer, C.J. Vardey
Publikováno v:
Cardiovascular Drug Reviews. 11:165-179
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d8dd383066a241fe1e1c1f95ed7b1c5
https://doi.org/10.1111/j.1527-3466.1993.tb00274.x
https://doi.org/10.1111/j.1527-3466.1993.tb00274.x
Autor:
Alan Wheeldon, C.J. Vardey
Publikováno v:
British Journal of Pharmacology. 108:1051-1054
1. We have evaluated the effects of various prostanoid agonists on the release of leukotriene B4 (LTB4) and superoxide anions (O2-) from human neutrophils stimulated with opsonized zymosan (OZ) and formyl-methionyl-leucyl-phenylalanine (FMLP), respec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e50fad45e09cfe537aad42c926bce985
https://doi.org/10.1111/j.1476-5381.1993.tb13504.x
https://doi.org/10.1111/j.1476-5381.1993.tb13504.x
Publikováno v:
British Journal of Pharmacology. 104:672-676
1. The effects of salmeterol, a novel long-acting beta 2-adrenoceptor agonist, have been investigated on antigen-induced mediator release from passively sensitized fragments of human lung in vitro. 2. Salmeterol was a potent inhibitor of the release
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7def71fc77dd5a2c6ae4807abd3c84f
https://doi.org/10.1111/j.1476-5381.1991.tb12487.x
https://doi.org/10.1111/j.1476-5381.1991.tb12487.x
Autor:
Peter R. Butchers, R.A. Coleman, M. Johnson, Alison A. Humbles, C.J. Vardey, Douglas I. Ball, Anthony T. Nials
Publikováno v:
European journal of pharmacology. 251(2-3)
Formoterol, like salbutamol and salmeterol, relaxed isolated preparations of guinea-pig trachea and human bronchus, and inhibited antigen-induced mediator release from human lung fragments in a concentration-related fashion. In each case, these actio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db3f442b871d3a788872e668248e3164
https://pubmed.ncbi.nlm.nih.gov/8149969
https://pubmed.ncbi.nlm.nih.gov/8149969
Autor:
E. Hornby, A. Wheeldon, Peter Strong, B. Evans, F. Ellis, M. F. Gurden, M. Foster, C.J. Vardey, J. Coates, D.P. Martin, I. Kennedy
1. The purpose of the present study was to classify adenosine receptors into A1 and A2 subtypes in a wide range of isolated tissues and cell types (rat adipocytes and atria, guinea-pig ileum and atria (A1); guinea-pig aorta, dog coronary artery and h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::477e43a9a1c18284c393306b69e22651
https://europepmc.org/articles/PMC2175648/
https://europepmc.org/articles/PMC2175648/
Autor:
Anthony T. Nials, M. Johnson, Clifford J Whelan, C.J. Vardey, P. Strong, M.J. Summer, P.R. Butchers, R.A. Coleman
Publikováno v:
Life sciences. 52(26)
Salmeterol was developed to provide prolonged bronchodilatation to control nocturnal symptoms and improve maintenance therapy in asthmatic patients. Salmeterol is > 10,000 times more lipophilic than salbutamol and has greater affinity for the beta 2-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bf97297834a06805e7effc851a7be3a
https://pubmed.ncbi.nlm.nih.gov/8099695
https://pubmed.ncbi.nlm.nih.gov/8099695