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pro vyhledávání: '"C.J. Kenyon"'
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Effects of the glucocorticoid antagonist RU486 in spontaneously hypertensive and Sprague Dawley rats
Publikováno v:
Journal of Endocrinological Investigation. 18:833-839
The effect of a low dose of the gluco-corticoid receptor antagonist, RU486, was tested in spontaneously hypertensive (SHR) and in Sprague Dawley (SD) rats. In SD rats, RU486 (50 micrograms/day, 18 days) significantly increased growth rate and thymus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc4212c7a5ffbc6265c4ebeec07ff577
https://doi.org/10.1007/bf03349829
https://doi.org/10.1007/bf03349829
Publikováno v:
International Journal of Pharmaceutics. 112:207-213
Eight healthy volunteers were entered into a randomised, open crossover study to investigate the in vivo behaviour of an enteric coated starch capsule. A radiolabelled preparation was administered to each volunteer on two occasions separated by 7 day
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a5e612913fc132639c0e6c0cd9d5c8a
https://doi.org/10.1016/0378-5173(94)90356-5
https://doi.org/10.1016/0378-5173(94)90356-5
Publikováno v:
Journal of Endocrinology. 135:361-369
We have previously reported that benzodiazepines inhibit microsomal steroid hydroxylases. We have now studied their effects at much lower drug concentrations and have also addressed the suggestion that benzodiazepines alter cellular calcium metabolis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::057625b9f192963fc946172fcbc5bbfe
https://doi.org/10.1677/joe.0.1350361
https://doi.org/10.1677/joe.0.1350361
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 39:839-850
18-Hydroxycortisol has been suggested as a marker compound for a transitional zone between the adrenocortical zonae glomerulosa and fasciculata. The control of secretion of 18-hydroxycortisol has been compared with those of cortisol and aldosterone i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2cf321ad7b81b6e922081bfcf042ce0
https://doi.org/10.1016/0960-0760(91)90034-3
https://doi.org/10.1016/0960-0760(91)90034-3
Publikováno v:
Journal of Endocrinology. 128:297-304
Angiotensin II (AII) stimulation of steroidogenesis is known to be associated with depolarization of the adrenocortical cell membrane. In these cells, membrane permeability to potassium ions governs electrical potential. The effects of All on the rat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bde9215eb1bce41359f23c5e31a5727
https://doi.org/10.1677/joe.0.1280297
https://doi.org/10.1677/joe.0.1280297
Publikováno v:
Endocrine Research. 17:225-236
Fast and slow K+ efflux components, independently regulated by angiotensin II (AII), have been identified in bovine adrenocortical cells. We have further investigated the role of potassium in the control of aldosterone synthesis in two ways. Firstly,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5541253488acdc03b35d2688aa0a0f9a
https://doi.org/10.1080/07435809109027199
https://doi.org/10.1080/07435809109027199
Publikováno v:
Steroids. 60:73-75
Glucocorticoid receptor binding was compared in liver cytosol preparations from spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats using homologous displacement of [3H]dexamethasone. At 5 degrees C, there was no difference in receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9250a55fcdcb05d513f91bd15889715b
https://doi.org/10.1016/0039-128x(94)00011-z
https://doi.org/10.1016/0039-128x(94)00011-z
Publikováno v:
Fundamentalclinical pharmacology. 13(2)
Previous studies have indicated that peripheral benzodiazepine receptor (PBR) ligands inhibit aldosterone secretion in isolated adrenal zona glomerulosa cells although positive responses have been demonstrated in other steroidogenic tissues. In the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c41ae937c9bea86150884beb7ee69ee0
https://pubmed.ncbi.nlm.nih.gov/10226766
https://pubmed.ncbi.nlm.nih.gov/10226766
Publikováno v:
Steroids. 62(4)
Carbenoxolone potentiates the mineralocorticoid activity of endogenous glucocorticoid hormones by inhibiting the enzyme 11 beta-hydroxysteroid dehydrogenase, which converts cortisol and corticosterone to inactive 11-oxo-derivatives. We addressed the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d711be511b7d514fc2297a24cc6a07ba
https://pubmed.ncbi.nlm.nih.gov/9090800
https://pubmed.ncbi.nlm.nih.gov/9090800