Zobrazeno 1 - 10
of 35
pro vyhledávání: '"C.H. Coles"'
Autor:
Conor Hayes, Marine C.C. Raman, C.H. Coles, Stephen Harper, Linda Hibbert, Patrick J. Lupardus, David K. Cole, Angharad Lloyd, Catriona McMurran, Miriam Hock
Publikováno v:
The Journal of Biological Chemistry
T cell-mediated immunity is governed primarily by T cell receptor (TCR) recognition of peptide-human leukocyte antigen (pHLA) complexes and is essential for immunosurveillance and disease control. This interaction is generally stabilized by interacti
Autor:
R. Martinez Hague, Fiona Chester, Jane Harper, S. Griffin, Angharad Lloyd, Emma Baston, R. Mulvaney, Annelise Vuidepot, K. Smith, S. Harper, K. Wiederhold, A.R. Stacey, Andrew Alexander Knox, S. Malla, K.L. Lowe, C.H. Coles, Z. Donnellan, Samantha Paston, Joseph Dukes, Bent K. Jakobsen, R.A. Robinson, M. Aleksic, A. Walker, Michelle L. McCully
Publikováno v:
The Journal of Immunology. 204:1943-1953
The molecular rules driving TCR cross-reactivity are poorly understood and, consequently, it is unclear the extent to which TCRs targeting the same Ag recognize the same off-target peptides. We determined TCR–peptide–HLA crystal structures and, u
Autor:
Sina Stern, Frank Bradke, Sebastian Dupraz, Andreas Husch, Brett J. Hilton, C.H. Coles, Cord Brakebusch, Telma E. Santos
Publikováno v:
Dupraz, S, Hilton, B J, Husch, A, Santos, T E, Coles, C H, Stern, S, Brakebusch, C & Bradke, F 2019, ' RhoA Controls Axon Extension Independent of Specification in the Developing Brain ', Current biology : CB, vol. 29, no. 22, pp. 3874-3886 . https://doi.org/10.1016/j.cub.2019.09.040
Current biology 29(22), 3874-3886.e9 (2019). doi:10.1016/j.cub.2019.09.040
Current biology 29(22), 3874-3886.e9 (2019). doi:10.1016/j.cub.2019.09.040
Summary The specification of an axon and its subsequent outgrowth are key steps during neuronal polarization, a prerequisite to wire the brain. The Rho-guanosine triphosphatase (GTPase) RhoA is believed to be a central player in these processes. Howe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d1078f2d06057c8606daaeb49d0f7fd
https://curis.ku.dk/portal/da/publications/rhoa-controls-axon-extension-independent-of-specification-in-the-developing-brain(b173f272-01ae-49d4-b908-4630138303be).html
https://curis.ku.dk/portal/da/publications/rhoa-controls-axon-extension-independent-of-specification-in-the-developing-brain(b173f272-01ae-49d4-b908-4630138303be).html
Autor:
Stephen Harper, Alex Powesland, Viren Patel, Ross A. Robinson, Jane Harper, David K. Cole, Vijay Karuppiah, David Berman, Velupillai Srikannathasan, C.H. Coles, Anitha Jevanthan
Publikováno v:
Cancer Research. 80:2271-2271
Introduction: Presentation of dysregulated or neoantigen peptides by human leukocyte antigens (pHLA) are a key source of novel targets for cancer immunotherapy. ImmTAC molecules are a novel class of T cell redirecting bispecific fusion protein that u
Publikováno v:
Seminars in cell & developmental biology 37, 98-107 (2015). doi:10.1016/j.semcdb.2014.09.007
The receptor protein tyrosine phosphatases (RPTPs) exhibit a wide repertoire of cellular signalling functions. In particular, type IIa RPTP family members have recently been highlighted as hubs for extracellular interactions in neurons, regulating ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e993e7389cc7559ceee97c2d2ccb677e
https://doi.org/10.1016/j.semcdb.2014.09.007
https://doi.org/10.1016/j.semcdb.2014.09.007
Autor:
Mariola J. Edelmann, David E. Lancaster, Kristina M. Cook, Jasmin Mecinović, Neil J. Oldham, Michael A. McDonough, Peter J. Ratcliffe, Mathew L. Coleman, Benedikt M. Kessler, C.H. Coles, Matthew E. Cockman, Kirsty S. Hewitson, Christopher J. Schofield
The stability and activity of hypoxia-inducible factor (HIF) are regulated by the post-translational hydroxylation of specific prolyl and asparaginyl residues. We show that the HIF asparaginyl hydroxylase, factor inhibiting HIF (FIH), also catalyzes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49caf3bb617c416f293f775fe9cd5767
https://ora.ox.ac.uk/objects/uuid:74826a6b-6a38-4c6a-a6bd-6253c0621f10
https://ora.ox.ac.uk/objects/uuid:74826a6b-6a38-4c6a-a6bd-6253c0621f10
Publikováno v:
Cancer Investigation. 30:422-432
The gene encoding PTPδ is mutated or downregulated in human cancers including neuroblastoma. Here, we functionally tested the tumor-suppressive potential of PTPδ in neuroblastoma cell lines by reconstitution of both short and long PTPδ isoforms. W
Autor:
E Y Jones, Robert Andrew Jeffrey McIlhinney, Karl Harlos, Elena Seiradake, Pavel V Perestenko, C.H. Coles, A R Aricescu
Publikováno v:
The EMBO Journal. 30:4479-4488
Brain wiring depends on cells making highly localized and selective connections through surface protein–protein interactions, including those between NetrinGs and NetrinG ligands (NGLs). The NetrinGs are members of the structurally uncharacterized
Autor:
Frank Bradke, C.H. Coles
Publikováno v:
Cell 158(2), 245-247 (2014). doi:10.1016/j.cell.2014.06.044
Adenomatous polyposis coli (APC) is a microtubule plus-end scaffolding protein important in biology and disease. APC is implicated in RNA localization, although the mechanisms and functional significance remain unclear. We show that APC is an RNA-bin
Autor:
A R Aricescu, David Harvey, C.H. Coles, Max Crispin, David I. Stuart, E Y Jones, Thomas A. Bowden, Karl Harlos
Publikováno v:
Journal of Molecular Biology. 387:1061-1066
Antibodies contain a conserved glycosylation site that has emerged as a target for the modulation of antibody effector functions. The crystal structure of a biosynthetic intermediate of human IgG1, bearing immature oligomannose-type glycans and repor