Zobrazeno 1 - 3
of 3
pro vyhledávání: '"C.G. Fryer"'
Publikováno v:
New England Journal of Medicine. 294:1364-1367
We used "high-dose" metronidazole, an "in vitro" and "in vivo" specific radiosensitizer of hypoxic cells, in a controlled trial to evaluate possible enhancement of radiation effect in patients with supratentorial glioblastomas. Thirty-six patients we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d352405ff12987d867179b0ef27bbfb
https://doi.org/10.1056/nejm197606172942503
https://doi.org/10.1056/nejm197606172942503
Clinical Phase I Study of the Hypoxic Cell Radiosensitizer RO-07-0582, A 2-Nitroimidazole Derivative
Publikováno v:
Radiology. 122:801-804
RO-07-0582 toxicity studies were performed in 12 patients for a total of 16 assays. Single and multifraction dose schedules were used, and drug concentrations in solid tumor tissue, cerebrospinal fluid, and blood (at 14 to 24 hr.) were established. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd85d5e167c1b63b0e64169ab0b19fab
https://doi.org/10.1148/122.3.801
https://doi.org/10.1148/122.3.801
Publikováno v:
Radiology. 117(1)
Metronidazole was administered orally to 25 patients and its maximum concentration in blood and tumor tissues, its ability to cross the blood/brain barrier and concentrate in the cerebrospinal fluid and brain tumor tissue, its immediate and long-term
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6addd5a1ad055f483392505c05adda1
https://pubmed.ncbi.nlm.nih.gov/1162051
https://pubmed.ncbi.nlm.nih.gov/1162051