Zobrazeno 1 - 6
of 6
pro vyhledávání: '"C.Eric Schwartz"'
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:1807-1809
Treatment of dextromethorphan 1 with various alkylating agents followed by base treatment led to Hoffman-type elimination reactions to produce a series of tricyclic derivatives, 6. These derivatives were characterized in vitro as sigma-1 receptor lig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ffb71a72e03ee3d1588f69d1526b7c0
https://doi.org/10.1016/j.bmcl.2003.12.105
https://doi.org/10.1016/j.bmcl.2003.12.105
Autor:
Bruce A. Littlefield, Zhaoyang Meng, C.Eric Schwartz, Celeste E. O'Connell, Kathleen A. Salvato
Publikováno v:
ChemInform. 30
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cecad346f6eda04697a6741d8bd8037f
https://doi.org/10.1002/chin.199937217
https://doi.org/10.1002/chin.199937217
Publikováno v:
Tetrahedron Letters. 33:7499-7502
A simple 2-step synthesis of B-ring substituted benzo[b]thiophene-2-carboxylates from aryl fluorides has been developed. The route involves a selective lithiation ortho to fluorine, followed by formylation, and subsequently, displacement of fluorine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aad673901c53321bab44ad22c4d1b135
https://doi.org/10.1016/s0040-4039(00)60806-7
https://doi.org/10.1016/s0040-4039(00)60806-7
Publikováno v:
Tetrahedron Letters. 33:7495-7498
Many para-substituted fluorobenzenes can be lithiated ortho to fluorine in moderate to good yields, often with one of the dialkylamide bases, lithium diisopropylamide (LDA) or lithium 2,2,6,6-tetramethylpiperidide (LiTMP). Intramolecular competition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cfc4fae264b18f7d12c254849ff44327
https://doi.org/10.1016/s0040-4039(00)60805-5
https://doi.org/10.1016/s0040-4039(00)60805-5
Autor:
Karen Ackermann, Ana Maria Garcia, Michael D. Lewis, Cheryl A. Rowell, C.Eric Schwartz, Celeste E. O'Connell
Publikováno v:
Bioorganicmedicinal chemistry letters. 9(14)
A series of peptidomimetics based on a hydroxyproline scaffold was prepared and evaluated for inhibition of farnesyltransferase and geranylgeranyltransferase I in both enzymatic and cell-based assays. A number of analogs were potent and selective inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d0b79a0112ec9714df1dc6b5d76871c
https://pubmed.ncbi.nlm.nih.gov/10450988
https://pubmed.ncbi.nlm.nih.gov/10450988
Publikováno v:
Bioorganicmedicinal chemistry. 1(6)
Efficient synthesis of structurally novel 4-substituted benzo[b]thiophene-2-carboxamidines 1-3, which selectively inhibit urokinase-type plasminogen activator (uPA) with IC50 values of 70-320 nM, are described. The key intermediate, methyl 4-iodobenz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7559c929176d4c0184aaca25436786db
https://pubmed.ncbi.nlm.nih.gov/8087561
https://pubmed.ncbi.nlm.nih.gov/8087561