Zobrazeno 1 - 10
of 103
pro vyhledávání: '"C.D. de Gooijer"'
Publikováno v:
Biotechnology and Bioengineering, 81(3), 269-278
Biotechnology and Bioengineering 81 (2003) 3
Biotechnology and Bioengineering 81 (2003) 3
Insect cells have been cultured for over 30 years, but their application is still hampered by low cell densities in batch fermentations and expensive culture media. With respect to the culture method, the fed-batch culture mode is often found to give
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5e01b396b5a83228fd22d871fcc6543
https://doi.org/10.1002/bit.10465
https://doi.org/10.1002/bit.10465
Publikováno v:
Cytotechnology. 29:167-176
The analysis of metabolic fluxes of large stoichiometric systems is sensitive to measurement errors in metabolic uptake and production rates. It is therefore desirable to independently test the consistency of measurement data, which is possible if at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd2c58f97a969ef9ab3725383a5be18a
https://doi.org/10.1023/a:1008063324292
https://doi.org/10.1023/a:1008063324292
Publikováno v:
Bioseparation. 7:117-126
The effect of the important ATPS- and buffer parameters on IgG and hybridoma partitioning in ATPSs containing a PEG-dye-ligand was studied. Objective was to establish selection criteria for effective ligands for extractive fermentations with animal c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a4f5dbd6598fc02531c90c44bc2cf3e
https://doi.org/10.1023/a:1008079626929
https://doi.org/10.1023/a:1008079626929
Publikováno v:
Biotechnology and Bioengineering, 58, 258-262
Biotechnology and Bioengineering 58 (1998)
Biotechnology and Bioengineering 58 (1998)
The estimation of intracellular fluxes of mammalian cells using only mass balances of the relevant metabolites is not possible because the set of linear equations defined by these mass balances is underdetermined. In order to quantify fluxes in cycli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::498304ba8a9e53e96d911566c5856dab
https://doi.org/10.1002/(sici)1097-0290(19980420)58:2/3<258::aid-bit20>3.0.co
https://doi.org/10.1002/(sici)1097-0290(19980420)58:2/3<258::aid-bit20>3.0.co
Autor:
Johannes Tramper, E. C. Beuvery, R. C. Dorresteijn, G. Wieten, M. C. Philippi, P. T. E. van Santen, C.D. de Gooijer
Publikováno v:
Cytotechnology. 23:19-28
The production of biologicals is subject to strict governmental regulations. These are drawn up in current good manufacturing practices (cGMP), a.o. by the U.S. Food and Drug Administration. To implement cGMP in a production facility, plant automatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12d049c92200195eaba9123ebc7a9dd9
https://doi.org/10.1023/a:1007923820231
https://doi.org/10.1023/a:1007923820231
Autor:
Ellen A. A. Nollen, E.C. Beuvery, C. A. M. van der Velden-de Groot, Johannes Tramper, Dirk E. Martens, M. Hardeveld, C.D. de Gooijer
Publikováno v:
Cytotechnology 21 (1996)
Cytotechnology, 21, 45-59
Cytotechnology, 23(1), 61-75. SPRINGER
Cytotechnology, 21(1), 45-59. SPRINGER
Cytotechnology, 21, 45-59
Cytotechnology, 23(1), 61-75. SPRINGER
Cytotechnology, 21(1), 45-59. SPRINGER
The death rate of Vero cells grown on Cytodex-3 microcarriers was studied as a function of the gas flow rate in a small air-lift loop reactor. The death rate may be described by first-order death-rate kinetics. The first-order death-rate constant as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e39cf95f2b46f6e149956b5ee17737c
https://doi.org/10.1023/b:cyto.0000010399.23373.65
https://doi.org/10.1023/b:cyto.0000010399.23373.65
Autor:
Manfred Biselli, J.J. van der Pol, C.D. de Gooijer, M Machnik, Johannes Tramper, C. Wandrey, T Portela-Klein
Publikováno v:
Cytotechnology. 24:19-30
The monoclonal-antibody production of an immobilized hybridoma cell line cultivated in a fluidized-bed reactor was monitored on-line for nearly 900 h. The monoclonal antibody concentration was determined by an immuno affinity-chromatography method (A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::330392caffd965f6bf9deb75c0058bbd
https://doi.org/10.1023/a:1007913128209
https://doi.org/10.1023/a:1007913128209
Publikováno v:
Enzyme and Microbial Technology, 19, 2-8
Enzyme and Microbial Technology 19 (1996)
Enzyme and Microbial Technology 19 (1996)
The design of aqueous two-phase systems (ATPSs) which support the long-term growth of animal cells is described in this paper. It was found that the increase in osmolality caused by the ATPS-forming polymers could be compensated by reducing the NaCl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06fd9686f19220cbc131f2e837267fe0
https://doi.org/10.1016/0141-0229(95)00173-5
https://doi.org/10.1016/0141-0229(95)00173-5
Publikováno v:
Biotechnology Letters 18 (1996)
Biotechnology Letters, 18, 397-402
Biotechnology Letters, 18, 397-402
The optimum design of a series of continuously operated stirred-tank reactors containing immobilised growing cells is described. Optimal design is defined as the minimal total holding time over the reactor series to achieve a certain degree of conver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8afb8bd22f9b942a03ae4512ac1d049
https://doi.org/10.1007/bf00143459
https://doi.org/10.1007/bf00143459
Publikováno v:
Journal of Chromatography A. 724:159-167
This paper presents a systematic approach to determine the optimal reaction conditions, with respect to accuracy and sensitivity, of the quantitative determination of primary amino acids in a single run, using o -phthalaldehyde-2-mercaptoethanol deri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8508e4e31d537bfbedd4974c6ec29c8
https://doi.org/10.1016/0021-9673(95)00927-2
https://doi.org/10.1016/0021-9673(95)00927-2