Does interference with the renin-angiotensin system protect against diabetes? Evidence and mechanisms

Autor: C.C.M. Moors, Ellen E. Blaak, Gijs H. Goossens, N.J. van der Zijl, Michaela Diamant

Publikováno v: Diabetes Obesity & Metabolism, 14(7), 586-595. Wiley
Diabetes, Obesity and Metabolism, 14(7), 586-595. Wiley-Blackwell
van der Zijl, N J, Moors, C C M, Goossens, G H, Blaak, E E & Diamant, M 2012, ' Does interference with the renin-angiotensin system protect against diabetes? Evidence and mechanisms ', Diabetes, Obesity and Metabolism, vol. 14, no. 7, pp. 586-595 . https://doi.org/10.1111/j.1463-1326.2012.01559.x

Agents interfering with the renin-angiotensin system (RAS) system were consistently shown to lower the incidence of type 2 diabetes (T2DM), as compared to other antihypertensive drugs, in hypertensive high-risk populations. The mechanisms underlying

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a9753285eb6e48dcdf6599da6966361
https://hdl.handle.net/1871/42415

Valsartan Improves β-Cell Function and Insulin Sensitivity in Subjects With Impaired Glucose Metabolism

Autor: Michaela Diamant, C.C.M. Moors, N.J. van der Zijl, Gijs H. Goossens, Ellen E. Blaak, M.M.H. Hermans

Publikováno v: Diabetes Care. 34:845-851

OBJECTIVE Recently, the Nateglinide and Valsartan in Impaired Glucose Tolerance Outcomes Research Trial demonstrated that treatment with the angiotensin receptor blocker (ARB) valsartan for 5 years resulted in a relative reduction of 14% in the incid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::19460fab620a911140d3e01d8feb72c3
https://doi.org/10.2337/dc10-2224

PUFAs acutely affect triacylglycerol-derived skeletal muscle fatty acid uptake and increase postprandial insulin sensitivity

Autor: Anneke Jans, Ellen Konings, C.C.M. Moors, Michael Müller, Gijs H. Goossens, Lydia A. Afman, Mark V. Boekschoten, Freek G. Bouwman, Ellen E. Blaak, Edwin C. M. Mariman

Publikováno v: American Journal of Clinical Nutrition 95 (2012)
American Journal of Clinical Nutrition, 95, 825-836
American Journal of Clinical Nutrition, 95(4), 825-836. Oxford University Press

Background: Dietary fat quality may influence skeletal muscle lipid processing and fat accumulation, thereby modulating insulin sensitivity. Objective: The objective was to examine the acute effects of meals with various fatty acid (FA) compositions

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ed77423a039f458f68a897eb5c80e33
https://pubmed.ncbi.nlm.nih.gov/22338035

Impaired insulin sensitivity is accompanied by disturbances in skeletal muscle fatty acid handling in subjects with impaired glucose metabolism

Autor: Ellen E. Blaak, Gijs H. Goossens, C.C.M. Moors, Michaela Diamant, N.J. van der Zijl

Publikováno v: International Journal of Obesity, 36(5), 709-717. Nature Publishing Group
Moors, C C M, van der Zijl, N J, Diamant, M, Blaak, E E & Goossens, G H 2012, ' Impaired insulin sensitivity is accompanied by disturbances in skeletal muscle fatty acid handling in subjects with impaired glucose metabolism ', International Journal of Obesity, vol. 36, no. 5, pp. 709-717 . https://doi.org/10.1038/ijo.2011.123

Objective:To determine insulin sensitivity and skeletal muscle fatty acid (FA) handling at baseline and after a high-fat mixed meal in impaired fasting glucose (IFG), impaired glucose tolerance (IGT), IFG/IGT and normal glucose tolerance (NGT) subjec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::459d87ca952a342856d58d5038dcb4c3
https://research.vumc.nl/en/publications/395da6d0-c1c7-4626-b7f4-95f70d414a79

Ectopic fat storage in the pancreas, liver, and abdominal fat depots: impact on β-cell function in individuals with impaired glucose metabolism

Autor: D. H. van Raalte, Petra J. W. Pouwels, Michaela Diamant, Ellen E. Blaak, Gijs H. Goossens, N.J. van der Zijl, Marcel H.A. Muskiet, C.C.M. Moors

Publikováno v: Journal of Clinical Endocrinology & Metabolism, 96(2), 459-467. Oxford University Press
van der Zijl, N J, Goossens, G H, Moors, C C M, van Raalte, D H, Muskiet, M H A, Pouwels, P J W, Blaak, E E & Diamant, M 2011, ' Ectopic fat storage in the pancreas, liver, and abdominal fat depots: impact on beta-cell function in individuals with impaired glucose metabolism ', Journal of Clinical Endocrinology and Metabolism, vol. 96, no. 2, pp. 459-467 . https://doi.org/10.1210/jc.2010-1722
Journal of Clinical Endocrinology and Metabolism, 96(2), 459-467. The Endocrine Society

Context: Pancreatic fat content (PFC) may have deleterious effects on β-cell function. Objective: We hypothesized that ectopic fat deposition, in particular pancreatic fat accumulation, is related to β-cell dysfunction in individuals with impaired

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9283d248e28569c3ec36d169f0c717d2
https://pubmed.ncbi.nlm.nih.gov/21084401