Rap-536 Induces Reticulocyte Maturation in Wild-Type Mice, Increases Survival of Beta-Thalassemic Reticulocytes, and Increases Red Blood Cells in a Mouse Model of Alpha-Thalassemia

Autor: Alexander V. Ratushny, Harish N. Ramanathan, Melih Acar, Martin Schwickart, Diana Ronai Dunshee, Daniel Menezes, Rajasekhar N.V.S. Suragani, Kyle J. MacBeth, Remco Loos, Roberto A Abbiati, C.C. Santini, Madhulika Jupelli

Publikováno v: Blood. 136:18-19

Luspatercept is a recombinant fusion protein that binds and sequesters several endogenous transforming growth factor-beta superfamily ligands, including growth differentiation factor 11, thereby diminishing Smad2/3 signaling in target cells involved

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::72b0043eafaeac6a48cfd4aa68b88539
https://doi.org/10.1182/blood-2020-137373

Global view of the RAF-MEK-ERK module and its immediate downstream effectors

Autor: Xuewei Wu, Craig D. Simpson, C.C. Santini, Erwin M. Schoof, Pau Creixell, Rune Linding, Neal Rosen, Grace R. Jeschke, Poulikos I. Poulikakos, Jin-Ho Kim, James Longden, Benjamin E. Turk

Publikováno v: Santini, C C, Longden, J, Schoof, E M, Simpson, C D, Jeschke, G R, Creixell, P, Kim, J, Wu, X, Turk, B E, Rosen, N, Poulikakos, P I & Linding, R 2019, ' Global view of the RAF-MEK-ERK module and its immediate downstream effectors ', Scientific Reports, vol. 9, no. 1, 10865 . https://doi.org/10.1038/s41598-019-47245-x
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)

Small molecule inhibitors of BRAF and MEK have proven effective at inhibiting tumor growth in melanoma patients, however this efficacy is limited due to the almost universal development of drug resistance. To provide advanced insight into the signali

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b87f2d46099e9946f5617d2ad18b4dc
https://orbit.dtu.dk/en/publications/bb485739-eb58-4ca4-8e45-24b530e3c662

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A DNA Network as an Information Processing System

Autor: C.C. Santini, Andrew J. Turberfield, Andy M. Tyrrell, Jonathan Bath

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 13, Iss 4, Pp 5125-5137 (2012)
International Journal of Molecular Sciences; Volume 13; Issue 4; Pages: 5125-5137

Biomolecular systems that can process information are sought for computational applications, because of their potential for parallelism and miniaturization and because their biocompatibility also makes them suitable for future biomedical applications

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb6e39ad333a8b011ca4465bf42eeff7
http://europepmc.org/articles/PMC3344270

A clocked finite state machine built from DNA

Autor: Andrew J. Turberfield, Jonathan Bath, C.C. Santini, Andy M. Tyrrell

Publikováno v: Chem. Commun.. 49:237-239

We implement a finite state machine by representing state, transition rules and input symbols with DNA components. Transitions between states are triggered by a clock signal which allows synchronized, parallel operation of two (or more) state machine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5b064a215e4b2771339d457dbeee343
https://doi.org/10.1039/c2cc37227d