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Exogenous alpha-synuclein hinders synaptic communication in cultured cortical primary rat neurons

Autor: C.C. Raiss, Ine M.J. Segers-Nolten, Vinod Subramaniam, R.J.A. van Wezel, Gerco Hassink, J. le Feber, Mireille M.A.E. Claessens

Publikováno v: PLoS One, 13
PLoS ONE, 13(3):e0193763. Public Library of Science
PLoS ONE
PLoS ONE, Vol 13, Iss 3, p e0193763 (2018)
PLoS One, 13, 3

Amyloid aggregates of the protein α-synuclein (αS) called Lewy Bodies (LB) and Lewy Neurites (LN) are the pathological hallmark of Parkinson's disease (PD) and other synucleinopathies. We have previously shown that high extracellular αS concentrat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ce808287343c115c6cf5b23ff8d8eea
http://hdl.handle.net/2066/190833

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The number of α-synuclein proteins per vesicle gives insights into its physiological function

Autor: Andreas R. Bausch, Carolus J. Siero, Christian Blum, Heinrich Grabmayr, Mireille M.A.E. Claessens, Niels Zijlstra, Mohammad Amin Abolghassemi Fakhree, C.C. Raiss

Publikováno v: Scientific reports, 6(30658):30658. Nature Publishing Group
Scientific Reports

Although it is well established that the protein α-synuclein (αS) plays an important role in Parkinson’s disease, its physiological function remains largely unknown. It has been reported to bind membranes and to play a role in membrane remodeling

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3167fbec5fee75a8d5988ccda6b9da79
https://doi.org/10.1038/srep30658

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The effect of exogenous human α-synuclein on neuronal network functionality

Autor: Jakob le Feber, Gerrit Cornelis Hassink, C.C. Raiss, Mireille M.A.E. Claessens

Publikováno v: ISSUE=10;TITLE=10th International Meeting on Substrate-Integrated Microelectrode Arrays, MEA 2016

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::757e93f442380a8e2ff17e88d58ee6a1
https://research.utwente.nl/en/publications/the-effect-of-exogenous-human-synuclein-on-neuronal-network-functionality(7e714d8a-983a-452d-89e6-e15f1bcf1cb9).html

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Functionally different α-synuclein inclusions yield insight into Parkinson’s disease pathology

Autor: Heinrich Grabmayr, Theresa S Braun, Casper Jansen, Mireille M.A.E. Claessens, Joost le Feber, Andreas R. Bausch, Gerco Hassink, Irene B.M. Konings, Vinod Subramaniam, Arshdeep Sidhu, C.C. Raiss

Publikováno v: Scientific reports, 6:23116. Nature Publishing Group
Scientific Reports, 6. Nature Publishing Group
Scientific Reports
Raiss, C C, Braun, T S, Konings, I B M, Grabmayr, H, Hassink, G C, Sidhu, A, le Feber, J, Bausch, A R, Jansen, C, Subramaniam, V & Claessens, M M A E 2016, ' Functionally different α-synuclein inclusions yield insight into Parkinson's disease pathology ', Scientific Reports, vol. 6, pp. 23116 . https://doi.org/10.1038/srep23116

The formation of α-synuclein (α-S) amyloid aggregates, called Lewy bodies (LBs), is a hallmark of Parkinson’s disease (PD). The function of LBs in the disease process is however still unclear; they have been associated with both neuroprotection a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a70e3892f5e6123a47022451186bd6f
https://doi.org/10.1038/srep23116

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Sonic Hedgehog-activated engineered blood vessels enhance bone tissue formation

Autor: Roman Truckenmüller, Jeroen Rouwkema, Carsten Sticht, Norbert Gretz, Anandkumar Nandakumar, Clemens van Blitterswijk, Nicolas C. Rivron, Jun Liu, C.C. Raiss

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 109(12), 4413-4418. National Academy of Sciences

Large bone defects naturally regenerate via a highly vascularized tissue which progressively remodels into cartilage and bone. Current approaches in bone tissue engineering are restricted by delayed vascularization and fail to recapitulate this stepw

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8feaaf4dd31f7ba6282d5244660d3e1
https://doi.org/10.1073/pnas.1117627109

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MicroRNA Levels as Prognostic Markers for the Differentiation Potential of Human Mesenchymal Stromal Cell Donors

Autor: Jan de Boer, Clemens van Blitterswijk, C.C. Raiss, Karolina Janaeczek Portalska, Marcel Karperien, Janine N. Post, Andre J. van Wijnen, Nicole Georgi, Nathalie Groen, Hanna Taipaleenmäki

Publikováno v: Stem Cells and Development, 24(16), 1946-1955. Mary Ann Liebert Inc.
Stem cells and development, 24(16), 1946-1955. Mary Ann Liebert

The ability of human mesenchymal stromal/stem cells (hMSCs) to differentiate into various mesenchymal cell lineages makes them a promising cell source for the use in tissue repair strategies. Since the differentiation potential of hMSCs differs betwe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3accfbe05ccc0af0e269ba8a8bbcea41
https://europepmc.org/articles/PMC4533023/

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