Zobrazeno 1 - 10
of 222
pro vyhledávání: '"C.A. Shuttleworth"'
Publikováno v:
Journal of Muscle Research and Cell Motility. 23:581-596
Fibrillin-rich microfibrils are evolutionarily ancient macromolecular assemblies of the extracellular matrix. They have unique extensible properties that endow vascular and other tissues with long-range elasticity. Microfibril extensibility supports
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bac5e8afd302b25df9f26ec9040bc694
https://doi.org/10.1023/a:1023479010889
https://doi.org/10.1023/a:1023479010889
Publikováno v:
Scopus-Elsevier
We have investigated recombinant fibrillin-1 (profib-1) and fibrillin-2 (glyfib-2) molecules encoding the proline- or glycine-rich regions with flanking domains (exons 9–11), in order to establish whether these sequences might mediate specific mole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9835a4bb2451be2ff7ca1f403a102532
https://doi.org/10.1242/jcs.112.20.3549
https://doi.org/10.1242/jcs.112.20.3549
Autor:
S D Shapiro, Matthew J. Rock, Michael J. Sherratt, Cay M. Kielty, Jane Ashworth, C.A. Shuttleworth, Gillian Murphy
Publikováno v:
Biochemical Journal. 340:171-181
Fibrillin is the principal structural component of the 10-12 nm diameter elastic microfibrils of the extracellular matrix. We have previously shown that both fibrillin molecules and assembled microfibrils are susceptible to degradation by serine prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3aaf3506af559c9a59ffb968f4ace4c7
https://doi.org/10.1042/bj3400171
https://doi.org/10.1042/bj3400171
Autor:
Jane Ashworth, C.A. Shuttleworth, Tim J Wess, P.P. Purslow, Cay M. Kielty, Michael J. Sherratt
Publikováno v:
The Journal of Cell Biology
Microfibrils are ubiquitous fibrillin-rich polymers that are thought to provide long-range elasticity to extracellular matrices, including the zonular filaments of mammalian eyes. X-ray diffraction of hydrated bovine zonular filaments demonstrated me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c5170a677810dbcb10137ff0bb7cf58
https://doi.org/10.1083/jcb.141.3.829
https://doi.org/10.1083/jcb.141.3.829
Autor:
Carolyn J.P. Jones, Cay M. Kielty, Rachel E.B. Watson, C.A. Shuttleworth, N.M. Craven, Christopher E.M. Griffiths
Publikováno v:
British Journal of Dermatology. 137:344-350
Chronically sun-exposed or photodamaged human skin is characterized by a number of clinical features, including wrinkles. However, little is known about the molecular mechanisms that underlie these features. We investigated the hypothesis that the me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5d955e607a37dc76207ded3f0fa96e9
https://doi.org/10.1046/j.1365-2133.1997.18471955.x
https://doi.org/10.1046/j.1365-2133.1997.18471955.x
Publikováno v:
British Journal of Dermatology. 137:17-23
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c24c0e288a9b381b78630e4ce928d8f
https://doi.org/10.1111/j.1365-2133.1997.tb03695.x
https://doi.org/10.1111/j.1365-2133.1997.tb03695.x
Publikováno v:
British Journal of Dermatology. 137:17-23
Fibrillin-containing microfibrils are key architectural structures of the upper dermis and integral components of the dermal elastic fibre network. Microfibril bundles intercalate into the dermal-epithelial junction and provide an elastic connection
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::511dba3f540758c0e71c5f5631dc722f
https://doi.org/10.1046/j.1365-2133.1997.1762185.x
https://doi.org/10.1046/j.1365-2133.1997.1762185.x
Publikováno v:
Journal of Cell Science. 108:1317-1323
Mutations in the FBN1 gene encoding the microfibrillar glycoprotein fibrillin cause Marfan syndrome, a relatively common autosomal dominant connective tissue disease. Causative FBN1 mutations appear to be dispersed throughout the coding frame, and to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51b63a7543e70ef841f29289139d8f83
https://doi.org/10.1242/jcs.108.3.1317
https://doi.org/10.1242/jcs.108.3.1317
Autor:
Cay M. Kielty, C.A. Shuttleworth
Publikováno v:
The Journal of Cell Biology
The microfibrillar glycoprotein fibrillin is linked to the Marfan syndrome, an autosomal dominant connective tissue disorder. In this study, fibrillin synthesis, deposition and assembly has been investigated in Marfan dermal fibroblast lines from two
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ee72294ca7d0de591e6b97afa7eef71
https://doi.org/10.1083/jcb.124.6.997
https://doi.org/10.1083/jcb.124.6.997
Autor:
Cay M. Kielty, C.A. Shuttleworth
Publikováno v:
Journal of Cell Science. 106:167-173
The expression and assembly of the microfibrillar glycoprotein fibrillin has been investigated in cultures of nuchal ligament fibroblasts, skin fibroblasts and vascular smooth muscle cells. The level of fibrillin expression varied with the cell type
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::817feac801fbae1bb74088d83d7cf801
https://doi.org/10.1242/jcs.106.1.167
https://doi.org/10.1242/jcs.106.1.167