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OP0193 EFFICACY AND SAFETY OF EMAPALUMAB, AN ANTI-INTERFERON GAMMA MONOCLONAL ANTIBODY, IN PATIENTS WITH MACROPHAGE ACTIVATION SYNDROME (MAS) IN SYSTEMIC JUVENILE IDIOPATHIC ARTHRITIS (sJIA) WHO HAD FAILED HIGH-DOSE GLUCOCORTICOIDS

Autor: F. De Benedetti, A. Grom, P. Brogan, C. Bracaglia, M. Pardeo, G. Marucci, D. Eleftheriou, C. Papadopoulou, P. Quartier, J. Anton, R. Frederiksen, V. Asnaghi, C. de Min

Publikováno v: Annals of the Rheumatic Diseases. 81:128.2-128

BackgroundMAS is a severe, life-threatening complication of rheumatic diseases that occurs most frequently in patients with sJIA. The mainstay of treatment for MAS is high dose glucocorticoids (GCs); however, GCs do not provide adequate control in al

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d38ef2818c1b798e55a9ba9b84611cbb
https://doi.org/10.1136/annrheumdis-2022-eular.803

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OP0290 EMAPALUMAB (ANTI-INTERFERON-GAMMA MONOCLONAL ANTIBODY) IN PATIENTS WITH MACROPHAGE ACTIVATION SYNDROME (MAS) COMPLICATING SYSTEMIC JUVENILE IDIOPATHIC ARTHRITIS (SJIA)

Autor: A. Grom, C de Min, F De Benedetti, Paul A. Brogan, Giulia Marucci, Philippe Jacqmin, R. Frederiksen, M Pardeo, Emanuela Sacco, Despina Eleftheriou, Charalampia Papadopoulou, Maria Ballabio, Claudia Bracaglia, R. Schneider, Pierre Quartier

Publikováno v: Annals of the Rheumatic Diseases. 79:180.1-180

Background:MAS is a severe complication of rheumatic diseases and occurs most frequently in patients with sJIA. Data from animal models and from observational studies in patients suggest that interferon gamma (IFNy) is a driver of the hyperinflammati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::045e4f3e7d0937bca4f242349dc21a4b
https://doi.org/10.1136/annrheumdis-2020-eular.3169

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Akademický článek

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Evidence of NI-0101 pharmacological activity, an anti-TLR4 antibody, in a randomized phase I dose escalation study in healthy volunteers receiving LPS

Autor: Philippe Jacqmin, C de Min, Emmanuel Monnet, Joannes A. A. Reijers, Matthijs Moerland, Geneviève Lapeyre, J. Burggraaf, K de Graaf, E van Poelgeest

Publikováno v: Clinical pharmacology and therapeutics, 101(2), 200-208. Wiley-Blackwell

Toll-like receptor-4 (TLR4) pathways are major contributors to pathological inflammatory responses induced by tissue damage. NI-0101 is the first monoclonal antibody (mAb) blocking TLR4 signaling. This activity is independent of the ligand type and c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2256c02a834b2597b28b6124036108e
https://pubmed.ncbi.nlm.nih.gov/27706798

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Akademický článek

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Modifications of thymulin titers in patients affected with prolonged low or high zinc circulating levels are independent of patients' age

Autor: Eugenio Mocchegiani, Nicola Fabris, T. Re, C. De Min, P. Travaglini

Publikováno v: Archives of Gerontology and Geriatrics. 15:349-357

Thymulin (FTS) is a thymic hormone, the bioactivity of which depends on zinc (Zn) incorporation in its molecule (FTS bioactive form: Zn-FTS). Many hormones (T3, GH, PRL, Gn-RH 6-endorphin) and Zn are able to increase thymus trophism and Zn-FTS circul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7196637b613e1c5a07a590208ba2914
https://doi.org/10.1016/s0167-4943(05)80036-6

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Zinc and bromocriptine long-term administration in patients with prolactinomas: Effects on prolactin and thymulin circulating levels

Autor: T. Re, Giovanni Faglia, Nicola Fabris, C. De Min, Eugenio Mocchegiani, P. Travaglini

Publikováno v: International Journal of Neuroscience. 59:119-125

Several studies have demonstrated zinc (Zn), prolactin (PRL) and thymulin (Zn-FTS) interplay: Zn inhibits, in a dose related manner, PRL release from lactotropes in vitro and stimulates thymulin synthesis in vivo both in humans and in animals. PRL re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::429a04fe44fabef1c9b2ad3ca572bb13
https://doi.org/10.3109/00207459108985454

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Thymic endocrine activity in children with idiopathic growth-hormone deficiency

Autor: Paolo Paolucci, Nicola Fabris, P. Travaglini, Alessandro Sartorio, Eugenio Mocchegiani, C. De Min

Publikováno v: International Journal of Neuroscience. 59:151-157

Experimental and clinical evidences suggest that thymic endocrine function is modulated by the neuroendocrine network and in particular by growth hormone. The plasma of thymulin has been found reduced in congenital hypopituitarism and increased in ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d57be3817734bc57a34b82de57fc2fa
https://doi.org/10.3109/00207459108985458

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