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Quercetin Interrupts the Positive Feedback Loop Between STAT3 and IL-6, Promotes Autophagy, and Reduces ROS, Preventing EBV-Driven B Cell Immortalization

Autor: Roberta Gonnella, Maria Saveria Gilardini Montani, Roberta Santarelli, Gabriella D'Orazi, Maria Anele Romeo, Marisa Granato, C. Zompetta, Mara Cirone, Alberto Faggioni

Publikováno v: Biomolecules, Vol 9, Iss 9, p 482 (2019)
Biomolecules
Volume 9
Issue 9

The oncogenic gammaherpesvirus Epstein&ndash
Barr virus (EBV) immortalizes in vitro B lymphocytes into lymphoblastoid cell lines (LCLs), a model that gives the opportunity to explore the molecular mechanisms driving viral tumorigenesis. In this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3caa4a7edb646dbbc0c444d705ba95f0
https://www.mdpi.com/2218-273X/9/9/482

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HCV derived from sera of HCV-infected patients induces pro-fibrotic effects in human primary fibroblasts by activating GLI2

Autor: Sandro Valia, A. Cardi, Enrica Vescarelli, Celeste Rizzello, Guido Antonelli, Mara Cirone, Cinzia Marchese, Alberto Faggioni, C. Zompetta, Marisa Granato, Maria Rosaria Torrisi

Publikováno v: Scientific Reports

Hepatitis C virus (HCV) infection is a leading cause of liver fibrosis, especially in developing countries. The process is characterized by the excess accumulation of ECM that may lead, over time, to hepatic cirrhosis, liver failure and also to hepat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfc61c182fede6e9251880405d5fe62a
https://pubmed.ncbi.nlm.nih.gov/27476557

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PML-RARα is associated with leptin-receptor induction: the role of mesenchymal stem cell–derived adipocytes in APL cell survival

Autor: Elihu H. Estey, Yoko Tabe, Shourong Zhao, Mark F. Munsell, Sherry Pierce, Twee Tsao, Michael Andreeff, C. Zompetta, Frank C. Marini, Jun Igari, Teresa McQueen, Marina Konopleva

Publikováno v: Blood. 103:1815-1822

Leptin is secreted by bone marrow (BM) adipocytes and stromal cells and was shown to stimulate myeloid proliferation. We here report that primary acute promyelocytic leukemia (APL) cells express high levels of the leptin-receptor (OB-R) long isoform.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c19e8b1a77ed6646e8413e5d5eb4717
https://doi.org/10.1182/blood-2003-03-0802

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Intracellular Transport and Maturation Pathway of Human Herpesvirus 6

Autor: Maria Rosaria Torrisi, Massimo Gentile, Mara Cirone, Lavinia Vittoria Lotti, Luigi Frati, Alberto Faggioni, Giorgia Cardinali, C. Zompetta

Publikováno v: Virology. 257:460-471

A peculiar characteristic of cells infected with human herpesvirus 6 (HHV6) is the absence of viral glycoproteins on the plasma membrane, which may reflect an atypical intracellular transport of the virions and/or the viral glycoproteins, different f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5eafb759f07e60e28b2b7413ca52b148
https://doi.org/10.1006/viro.1999.9699

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Human herpes virus-6 seroprevalence and leukaemias: a case-control study

Autor: G Castelli, Giuseppe Gentile, Alfonso Mele, C. Zompetta, Bruno Monarca, Giuseppe Ragona, P. Martino, Maria Elena Tosti, Alessandro Pulsoni, Alberto Faggioni, Franco Mandelli, Giuseppe Visani

Publikováno v: British Journal of Cancer

The relationships between acute myeloid leukaemia (AML), acute lymphocytic leukaemia (ALL), chronic myeloid leukaemia (CML) and refractory anaemia with excess of blasts (RAEB) and human herpes virus (HHV)-6 antibody level were investigated in a multi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1431d19ad98796506382e4fd558b959
http://europepmc.org/articles/PMC2363056

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Partition of epidermal growth factor receptors on freeze-fractured plasma membranes of A431 cells is affected by the ligand

Autor: Maria Rosaria Torrisi, Lavinia Vittoria Lotti, Patrizia Mancini, Antonio Pavan, Alberto Faggioni, Luigi Frati, C. Zompetta

Publikováno v: Scopus-Elsevier

The fracture immunolabel technique, which permits assessment of the partition of transmembrane proteins with the inner or outer leaflets of the freeze-fractured membrane, was used to analyze the behavior on fracture of epidermal growth factor (EGF) r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee0f8a2f96384d803bf77e291b372970
https://doi.org/10.1177/39.9.1918941

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The Oxyradical-Scavenging Activity of Azelaic Acid in Biological Systems

Autor: Mauro Picardo, C. Zompetta, Chiara De Luca, M. Nazzaro-Porro, Siro Passi, Aidon S. Breathnach

Publikováno v: Free Radical Research Communications. 15:17-28

We have previously shown that azelaic acid, a C9 dicarboxylic acid, as disodium salt (C(9)2Na) is capable of inhibiting significantly the hydroxylation of aromatic compounds and the peroxidation of arachidonic acid due to reactive hydroxyl radicals (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb966da0c2b8b6927e58a7e56babf82f
https://doi.org/10.3109/10715769109049121

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Epstein-barr virus internalization and infectivity are blocked by selective protein kinase C inhibitors

Autor: Luigi Frati, Marco Venanzoni, Mara Cirone, C. Zompetta, Antonio Angeloni, Alberto Faggioni, Maria Rosaria Torrisi, Giuseppe Barile

Publikováno v: International Journal of Cancer. 45:490-493

Selective protein kinase C inhibitors can either block or significantly reduce Epstein-Barr virus infectivity: inhibition of transformation and decreased 3H-thymidine (3H-TdR) incorporation in human B lymphocytes infected with B95-8 EBV, as well as a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::142fd0c6ac6a732d130b979c460d37d2
https://doi.org/10.1002/ijc.2910450320

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Infection of HHV-8+ primary effusion lymphoma cells with a recombinant Epstein-Barr virus leads to restricted EBV latency, altered phenotype, and increased tumorigenicity without affecting TCL1 expression

Autor: Stefania Uccini, Kenzo Takada, Elena Anastasiadou, Filippo Belardelli, Alberto Faggioni, Laura Cuomo, C. Zompetta, Antonino Carbone, Pankaj Trivedi, Kumi Takazawa, Luigi Frati

Publikováno v: Blood. 103(1)

To investigate the role of Epstein-Barr virus (EBV) in the pathogenesis of primary effusion lymphoma (PEL), we infected human herpesvirus 8 (HHV-8+) but EBV- PEL lines BC-3, CRO-AP/6, and CRO-AP/3 cells with the recombinant Akata EBV strain. All EBV-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::537b5e5341c04567fd0ff276ae4fd4a1
https://pubmed.ncbi.nlm.nih.gov/12969959

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