Stereoselective Hydrogen Transfer Reactions Involving Acyclic Radicals. Tandem Substituted Tetrahydrofuran Formation and Stereoselective Reduction: Synthesis of the C17-C22 Subunit of Ionomycin

Autor: C. Yoakim, Vida Gorys, J. Renaud, Daniel Delorme, J.‐F. Lavallee, Yvan Guindon, William W. Ogilvie, A. Slassi, G. Robinson

Publikováno v: The Journal of Organic Chemistry. 59:1166-1178

The tandem iodoetherification reaction and stereoselective reduction of acyclic radicals has been used in the stereocontrolled synthesis of substituted tetrahydrofurans. Such a tetrahydrofuran intermediate is regioselectively cleaved using Me 2 BBr t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::304323ee85ab0a3f3ac13fe93206c75e
https://doi.org/10.1021/jo00084a040

ChemInform Abstract: Stereoselective Opening of Acetals Derived from Dimethyl Tartrate

Autor: C. Yoakim, Yvan Guindon, R. Lemieux, Bruno Simoneau, Vida Gorys, William W. Ogilvie

Publikováno v: ChemInform. 23

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6cfc7c021d80e8df5377d833c4f13ec4
https://doi.org/10.1002/chin.199224106

Application of an NMR/Crystallography Fragment Screening Platform for the Assessment and Rapid Discovery of New HIV-CA Binding Fragments.

Autor: Lang S; Cresset Discovery, New Cambridge House, Bassingbourn Road, Litlington, Cambridgeshire, SG80SSS., Fletcher DA; BioAscent Discovery Ltd, Bo'Ness Road, Newhouse, Lanarkshire, ML1 5UH., Petit AP; Drug Discovery Unit, University of Dundee, Dow Street, Dundee, DD1 5EH., Luise N; Alira Health, Av. De Josep Tarradellas, 123, 7th Floor, 08029, Barcelona, Spain., Fyfe P; Drug Discovery Unit, University of Dundee, Dow Street, Dundee, DD1 5EH., Zuccotto F; Vertex Pharmaceuticals (Europe) Ltd, 86-88, Jubilee Avenue, Milton Park, Abingdon, Oxfordshire, OX14 4RW., Porter D; Evotec (UK) Ltd, Dorothy Crowfoot Hodgkin Campus, 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire, OX14 4RZ., Hope A; Drug Discovery Unit, University of Dundee, Dow Street, Dundee, DD1 5EH., Bellany F; Drug Discovery Unit, University of Dundee, Dow Street, Dundee, DD1 5EH., Kerr C; Drug Discovery Unit, University of Dundee, Dow Street, Dundee, DD1 5EH., Mackenzie CJ; Drug Discovery Unit, University of Dundee, Dow Street, Dundee, DD1 5EH., Wyatt PG; Sitala Bio Ltd, Unit D6, Grain House Mill Court, Great Shelford, Cambridge, CB22 5LD., Gray DW; Drug Discovery Unit, University of Dundee, Dow Street, Dundee, DD1 5EH.

Publikováno v: ChemMedChem [ChemMedChem] 2024 Jul 02; Vol. 19 (13), pp. e202400025. Date of Electronic Publication: 2024 May 06.

Opening of tartrate acetals using dialkylboron bromide: evidence for stereoselectivity downstream from ring fission

Autor: Kathy Durkin, R. Lemieux, Vida Gorys, Wei Li Cui, Josée Bordeleau, C. Yoakim, Yvan Guindon, Bruno Simoneau, William W. Ogilvie, Hélène Juteau, Dennis C. Liotta

Publikováno v: Journal of the American Chemical Society. 125(2)

Johnson-type acetals derived from dimethyl tartrate give, after opening with Me(2)BBr and cuprate displacement, secondary alcohols with high diastereoselectivity (30:1). The mechanism proposed for the induction of diastereoselectivity is downstream f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37dd2a95bda84acc7ef002c8cd875f25
https://pubmed.ncbi.nlm.nih.gov/12517155

Enantioselective synthesis of molecules with multiple stereogenic elements.

Autor: Gaucherand, Arthur, Yen-Pon, Expédite, Domain, Antoine, Bourhis, Alix, Rodriguez, Jean, Bonne, Damien

Publikováno v: Chemical Society Reviews; 11/21/2024, Vol. 53 Issue 22, p11165-11206, 42p