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pro vyhledávání: '"C. Y. Eleanor Fung"'
Autor:
Catherine Vial, C. Y. Eleanor Fung, Martyn P. Mahaut-Smith, Alison H. Goodall, Richard J. Evans
Publikováno v:
Biochemical and Biophysical Research Communications. 343:415-419
ATP-stimulated P2X1 and ADP-stimulated P2Y1 receptors play important roles in platelet activation. An increase in intracellular Ca2+ represents a key signalling event coupled to both of these receptors, mediated via direct gating of Ca2+-permeable ch
Publikováno v:
Thrombosis and Haemostasis. 94:37-40
SummaryIn the platelet, ATP-gated P2X1 receptors have been reported to amplify functional responses to collagen, however the relative importance of early Ca2+ mobilisation events is unknown. We now report that selective desensitisation of P2X1 recept