Robust continuous in vitro culture of the Plasmodium cynomolgi erythrocytic stages

Autor: Adeline C. Y. Chua, Jessica Jie Ying Ong, Benoit Malleret, Rossarin Suwanarusk, Varakorn Kosaisavee, Anne-Marie Zeeman, Caitlin A. Cooper, Kevin S. W. Tan, Rou Zhang, Bee Huat Tan, Siti Nurdiana Abas, Andy Yip, Anne Elliot, Chester J. Joyner, Jee Sun Cho, Kate Breyer, Szczepan Baran, Amber Lange, Steven P. Maher, François Nosten, Christophe Bodenreider, Bryan K. S. Yeung, Dominique Mazier, Mary R. Galinski, Nathalie Dereuddre-Bosquet, Roger Le Grand, Clemens H. M. Kocken, Laurent Rénia, Dennis E. Kyle, Thierry T. Diagana, Georges Snounou, Bruce Russell, Pablo Bifani

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)

Present understanding of Plasmodium vivax biology is hampered by its inability to grow in vitro. Here, the authors developed an in vitro culture of its simian counterpart, P. cynomolgi, which shares morphological and phenotypic similarities with P. v

Externí odkaz: https://doaj.org/article/68f08622b7b941e08fb8d5ecab44264a

Ocular Perfusion Pressure and Severity of Glaucoma: Is There a Link?

Autor: T W Ch'ng, M A Ummi Kalsom, C Y Chua, Vhm Gong, Y Azhany, Ahg Rasool, Ahmad Tajudin Liza-Sharmini

Publikováno v: Journal of Current Glaucoma Practice

Aim and objective To establish the association between 12-month inter-visits ocular perfusion pressure (OPP) and severity of glaucoma. Materials and methods A total of 164 eyes (60 primary open-angle glaucoma, 52 normal-tension glaucoma, and 52 prima

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77e608c1788257e8ff0234422484b7b4
http://europepmc.org/articles/PMC8543740

Robust continuous in vitro culture of the Plasmodium cynomolgi erythrocytic stages

Autor: Kevin S. W. Tan, Kate Breyer, Georges Snounou, Clemens H. M. Kocken, Anne Elliot, Bruce Russell, Varakorn Kosaisavee, Bryan K. S. Yeung, Bee Huat Tan, Adeline C. Y. Chua, Rossarin Suwanarusk, Siti Nurdiana Abas, Rou Zhang, Anne-Marie Zeeman, Jee Sun Cho, Benoit Malleret, Laurent Rénia, Roger Le Grand, Dennis E. Kyle, Mary R. Galinski, Christophe Bodenreider, Nathalie Dereuddre-Bosquet, Chester J. Joyner, François Nosten, Dominique Mazier, Szczepan W Baran, Pablo Bifani, Amber Lange, Jessica Jie Ying Ong, Thierry T. Diagana, Steven P. Maher, Caitlin A. Cooper, Andy M. Yip

Publikováno v: Nature Communications
Nature Communications, Nature Publishing Group, 2019, 10 (1), ⟨10.1038/s41467-019-11332-4⟩
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications, 2019, 10 (1), ⟨10.1038/s41467-019-11332-4⟩

The ability to culture pathogenic organisms substantially enhances the quest for fundamental knowledge and the development of vaccines and drugs. Thus, the elaboration of a protocol for the in vitro cultivation of the erythrocytic stages of Plasmodiu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90fd9b03ad20049d99276309712f02ba
https://hal.archives-ouvertes.fr/hal-02347287

Mutations in Genes for the F 420 Biosynthetic Pathway and a Nitroreductase Enzyme Are the Primary Resistance Determinants in Spontaneous In Vitro -Selected PA-824-Resistant Mutants of Mycobacterium tuberculosis

Autor: René Wintjens, Hana L. Haver, Pramila Baban Ghode, Amit Singhal, Adeline C. Y. Chua, Pablo Bifani, Suresh B. Lakshminarayana, Barun Mathema

Publikováno v: Antimicrobial Agents and Chemotherapy. 59:5316-5323

Alleviating the burden of tuberculosis (TB) requires an understanding of the genetic basis that determines the emergence of drug-resistant mutants. PA-824 (pretomanid) is a bicyclic nitroimidazole class compound presently undergoing the phase III STA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6730fdaf7982797914c00237bcd82ffd
https://doi.org/10.1128/aac.00308-15

Quantitative Proteomic Analysis of Simian Primary Hepatocytes Reveals Candidate Molecular Markers for Permissiveness to Relapsing Malaria Plasmodium cynomolgi

Autor: Siu Kwan Sze, Adeline C. Y. Chua, Bamaprasad Dutta, Laurent Dembele, Devendra Kumar Gupta, Pablo Bifani

Publikováno v: PROTEOMICS. 19:1900021

A major obstacle impeding malaria research is the lack of an in vitro system capable of supporting infection through the entire liver stage cycle of the parasite, including that of the dormant forms known as hypnozoites. Primary hepatocytes lose thei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::151cdf0028940883604558938e35d4e1
https://doi.org/10.1002/pmic.201900021