Zobrazeno 1 - 10
of 150
pro vyhledávání: '"C. Wykes"'
Autor:
Aytakin Khalil, Tawfeeq Shekh‐Ahmad, Stjepana Kovac, Robert C. Wykes, F. David Horgen, Andrea Fleig, Matthew C. Walker
Publikováno v:
Epilepsia Open, Vol 8, Iss 3, Pp 1169-1174 (2023)
Abstract Transient receptor potential cation subfamily M7 (TRPM7) channels are ion channels permeable to divalent cations. They are abundantly expressed with particularly high expression in the brain. Previous studies have highlighted the importance
Externí odkaz:
https://doaj.org/article/240cc6bee7674228b4e4ade754230b6a
Autor:
Armand Blondiaux, Shaobo Jia, Anil Annamneedi, Gürsel Çalışkan, Jana Nebel, Carolina Montenegro-Venegas, Robert C. Wykes, Anna Fejtova, Matthew C. Walker, Oliver Stork, Eckart D. Gundelfinger, Alexander Dityatev, Constanze I. Seidenbecher
Publikováno v:
Neurobiology of Disease, Vol 188, Iss , Pp 106324- (2023)
Epilepsies are multifaceted neurological disorders characterized by abnormal brain activity, e.g. caused by imbalanced synaptic excitation and inhibition. The neural extracellular matrix (ECM) is dynamically modulated by physiological and pathophysio
Externí odkaz:
https://doaj.org/article/58510b50333f47f092cb98e4bfabdd21
Autor:
Fred Mulroe, Wei-Hsiang Lin, Connie Mackenzie-Gray Scott, Najat Aourz, Yuen Ngan Fan, Graham Coutts, R. Ryley Parrish, Ilse Smolders, Andrew Trevelyan, Robert C. Wykes, Stuart Allan, Sally Freeman, Richard A. Baines
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 10 (2022)
Externí odkaz:
https://doaj.org/article/3c30c2a06d484e9abf1e1f9a183c7038
Autor:
Amirhossein Jafarian, Rob C. Wykes
Publikováno v:
Frontiers in Computational Neuroscience, Vol 16 (2022)
We propose that to fully understand biological mechanisms underlying pathological brain activity with transitions (e.g., into and out of seizures), wide-bandwidth electrophysiological recordings are important. We demonstrate the importance of ultrasl
Externí odkaz:
https://doaj.org/article/6bf18fffe2804788a5f540d68b4ab60a
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 7, Pp n/a-n/a (2022)
Externí odkaz:
https://doaj.org/article/4552335ec519483683ea19b0df7de0da
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Glioblastoma (GBM) is the most common and advanced form of primary malignant tumor occurring in the adult central nervous system, and it is frequently associated with epilepsy, a debilitating comorbidity. Seizures are observed both pre- and post-surg
Externí odkaz:
https://doaj.org/article/85cef373e508484f901d5d2899a1110f
Autor:
Justin L. Tosh, Elena R. Rhymes, Paige Mumford, Heather T. Whittaker, Laura J. Pulford, Sue J. Noy, Karen Cleverley, LonDownS Consortium, Matthew C. Walker, Victor L. J. Tybulewicz, Rob C. Wykes, Elizabeth M. C. Fisher, Frances K. Wiseman
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Individuals who have Down syndrome (caused by trisomy of chromosome 21), have a greatly elevated risk of early-onset Alzheimer’s disease, in which amyloid-β accumulates in the brain. Amyloid-β is a product of the chromosome 21 gene APP (
Externí odkaz:
https://doaj.org/article/976af835ad394de686b40b465f483f68
Publikováno v:
NeuroImage, Vol 238, Iss , Pp 118243- (2021)
This technical note introduces adiabatic dynamic causal modelling, a method for inferring slow changes in biophysical parameters that control fluctuations of fast neuronal states. The application domain we have in mind is inferring slow changes in va
Externí odkaz:
https://doaj.org/article/2cd27781d2fd4d1b8062b8d18dbabe92
Autor:
Justin L. Tosh, Elena R. Rhymes, Paige Mumford, Heather T. Whittaker, Laura J. Pulford, Sue J. Noy, Karen Cleverley, LonDownS Consortium, Matthew C. Walker, Victor L. J. Tybulewicz, Rob C. Wykes, Elizabeth M. C. Fisher, Frances K. Wiseman
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-2 (2021)
Externí odkaz:
https://doaj.org/article/f4f8885c12774514a5a399bb7470b3ea
Autor:
R. Ryley Parrish, Connie MacKenzie-Gray Scott, Tom Jackson-Taylor, Alex Grundmann, Faye McLeod, Neela K. Codadu, Alexandru Călin, Hannah Alfonsa, Rob C. Wykes, Juha Voipio, Andrew J. Trevelyan
Publikováno v:
The Journal of Neuroscience. 43:685-692
The movement of ions in and out of neurons can exert significant effects on neighboring cells. Here we report several experimentally important consequences of activation of the optogenetic chloride pump, halorhodopsin. We recorded extracellular K+con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::221d91b439c74cf82b768b7a54a6bf41
https://doi.org/10.1523/jneurosci.1141-22.2022
https://doi.org/10.1523/jneurosci.1141-22.2022