Zobrazeno 1 - 10
of 53
pro vyhledávání: '"C. William Davis"'
Autor:
Yunxiang Zhu, Lubna H Abdullah, Sean P Doyle, Kristine Nguyen, Carla M P Ribeiro, Paula A Vasquez, M Gregory Forest, Michael I Lethem, Burton F Dickey, C William Davis
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0127267 (2015)
Airway mucin secretion studies have focused on goblet cell responses to exogenous agonists almost to the exclusion of baseline mucin secretion (BLMS). In human bronchial epithelial cell cultures (HBECCs), maximal agonist-stimulated secretion exceeds
Externí odkaz:
https://doaj.org/article/23c76bc6f5944e9f97db43bcc1a2d973
Autor:
Maria E Teves, Patrick R Sears, Wei Li, Zhengang Zhang, Waixing Tang, Lauren van Reesema, Richard M Costanzo, C William Davis, Michael R Knowles, Jerome F Strauss, Zhibing Zhang
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e107271 (2014)
SPAG6, an axoneme central apparatus protein, is essential for function of ependymal cell cilia and sperm flagella. A significant number of Spag6-deficient mice die with hydrocephalus, and surviving males are sterile because of sperm motility defects.
Externí odkaz:
https://doaj.org/article/fd8be5627c4f41c590d1c621a0538bcf
Autor:
C. William Davis, Ashley G. Henderson, Eugene R. Bleecker, Prescott G. Woodruff, Neil E. Alexis, Rui Cao, Agathe Ceppe, Wayne Anderson, Wanda K. O'Neal, Richard C. Boucher, MeiLan K. Han, Richard E. Kanner, Robert Paine, Nadia N. Hansel, R. Graham Barr, Giorgia Radicioni, Fernando J. Martinez, Amina A. Ford, Mehmet Kesimer, Christopher B. Cooper, Stephanie A. Christenson, Annette T. Hastie, Claire M. Doerschuk, Eric A. Hoffman
Publikováno v:
The New England journal of medicine, vol 377, iss 10
BackgroundChronic obstructive pulmonary disease (COPD) is characterized by chronic bronchitic and emphysematous components. In one biophysical model, the concentration of mucin on the airway surfaces is hypothesized to be a key variable that controls
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e3b39b0f1769ef8f598c42d5e952535
https://doi.org/10.1056/nejmoa1701632
https://doi.org/10.1056/nejmoa1701632
Autor:
Raymond D. Coakley, Brian Button, Bahjat F. Qaqish, Fred Fuller, Richard C. Boucher, Elena Bordonali, Mehmet Kesimer, Ashley G. Henderson, C. William Davis, Summer Bailey, Michael Rubinstein, Neil E. Alexis, Wayne Anderson, William D. Bennett, Martha Almond, David B. Peden, Eduardo R. Lazarowski, Kirby L. Zeman
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 192:182-190
Chronic bronchitis (CB) is characterized by persistent cough and sputum production. Studies were performed to test whether mucus hyperconcentration and increased partial osmotic pressure, in part caused by abnormal purine nucleotide regulation of ion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fb3c11de80a5ccf9ed123798d847c65
https://doi.org/10.1164/rccm.201412-2230oc
https://doi.org/10.1164/rccm.201412-2230oc
Autor:
Lubna H. Abdullah, Megan J. Webster, Carla Ribeiro, C. William Davis, Yunxiang Zhu, Raymond D. Coakley, Richard C. Boucher, Mehmet Kesimer, Giorgia Radicioni, Robert Tarran
Publikováno v:
American journal of respiratory and critical care medicine. 197(4)
Cystic fibrosis (CF) airways disease produces a mucoobstructive lung phenotype characterized by airways mucus plugging, epithelial mucous cell metaplasia/hyperplasia, chronic infection, and inflammation. Simultaneous biochemical and functional in viv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb6ac6b4e7e679819751b46dcef64a57
https://pubmed.ncbi.nlm.nih.gov/29298399
https://pubmed.ncbi.nlm.nih.gov/29298399
Autor:
Raymond D. Coakley, Kristine Nguyen, T. Tiffany Wang, Jessica R. Evans, Alexander M. Makhov, Jack D. Griffith, Stephen T. Ballard, Mehmet Kesimer, Lubna H. Abdullah, Amina A. Ford, C. William Davis
In cystic fibrosis (CF), airway mucus becomes thick and viscous, and its clearance from the airways is impaired. The gel-forming mucins undergo an ordered "unpacking/maturation" process after granular release that requires an optimum postsecretory en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21eb2a99ece3840b26cf2c3058aac786
https://europepmc.org/articles/PMC5358479/
https://europepmc.org/articles/PMC5358479/
Autor:
James R. Yankaskas, Heiner Neubauer, Lubna H. Abdullah, Scott H. Randell, Peter H. Gilligan, Richard C. Boucher, C. William Davis, Roland R. Arnold, Daniel B. Albert, Olivia Perlmutt, Ute E. Schwab
Publikováno v:
Infection and Immunity. 82:4729-4745
The localization of Burkholderia cepacia complex (Bcc) bacteria in cystic fibrosis (CF) lungs, alone or during coinfection with Pseudomonas aeruginosa , is poorly understood. We performed immunohistochemistry for Bcc and P. aeruginosa bacteria on 21
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7f8c45ba9418b573a9c8c0d308e8c27
https://doi.org/10.1128/iai.01876-14
https://doi.org/10.1128/iai.01876-14
Autor:
John K. Sheehan, Brian Button, Scott H. Donaldson, Hiro Matsui, Ashley G. Henderson, Liheng Cai, Camille Ehre, Mehmet Kesimer, Margaret W. Leigh, C. William Davis, Lubna H. Abdullah, Richard C. Boucher, Genevieve DeMaria
Publikováno v:
Journal of Clinical Investigation. 124:3047-3060
The pathogenesis of mucoinfective lung disease in cystic fibrosis (CF) patients likely involves poor mucus clearance. A recent model of mucus clearance predicts that mucus flow depends on the relative mucin concentration of the mucus layer compared w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b1b8eb17ee65a2503b0f44fdcc1a6e6
https://doi.org/10.1172/jci73469
https://doi.org/10.1172/jci73469
Autor:
David A. Schwartz, Michael J. Tuvim, Richard C. Boucher, Lindsey K. Bellinghausen, Joseph H. Sisson, Catherine A. Lozupone, Samantha N. Alexander, Jody Donnelly, Alfred S. Song, Adela Cota-Gomez, M. Gabriela Bowden, David J. Thornton, Andrea S. Bordt, Kristy A. Terrell, Michelle G. Roy, Irlanda Romo, Scott E. Evans, C. William Davis, Karine Rousseau, Christopher M. Evans, Michael R. Blackburn, Corinne E. Hennessy, Scott M. Drouin, Lea Barthel, Wanda K. O'Neal, Barbara R. Grubb, Ashley A. Fletcher, Youlia Petrova, Harry Karmouty-Quintana, Alessandra Livraghi-Butrico, Melissa M. McElwee, Rebecca C. Keith, Seyed Javad Moghaddam, William J. Janssen, Sonia C. Flores, Roberto Adachi, Burton F. Dickey, Peter M. Henson, Alan M. Watson, Ivana V. Yang, Maria Miguelina De La Garza, Prescott G. Woodruff, Ryan M. Boerner
Publikováno v:
Nature. 505:412-416
Respiratory surfaces are exposed to billions of particulates and pathogens daily. A protective mucus barrier traps and eliminates them through mucociliary clearance (MCC). However, excessive mucus contributes to transient respiratory infections and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19a04cb5a95797fa3c27ebf1280e5d3a
https://doi.org/10.1038/nature12807
https://doi.org/10.1038/nature12807
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 304:L170-L183
Airway cilia depend on precise changes in shape to transport the mucus gel overlying mucosal surfaces. The ciliary motion can be recorded in several planes using video microscopy. However, cilia are densely packed, and automated computerized systems
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcecbfad6a4b3d4715d7dca28afda6d8
https://doi.org/10.1152/ajplung.00105.2012
https://doi.org/10.1152/ajplung.00105.2012