Zobrazeno 1 - 10 of 27 pro vyhledávání: '"C. Wegbrod"'
1
Insulin mRNA is stored in RNA granules in resting beta cells
Autor: K. Ganß, E. Quezada, Anke Sönmez, Matthias Selbach, Carla Münster, Michele Solimena, C. Wegbrod, Nicole Kipke, Marius Distler, J. Vasiljević, Eyke Schöniger, Djordje Vasiljevic, D. Friedland
The glucose-stimulated biosynthesis of insulin in pancreatic islet beta cells is post-transcriptionally regulated. Several RNA-binding proteins (RBPs) that regulate Insulin mRNA stability and translation also bind mRNAs coding for other insulin secre
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a0d96a12029bbbe4e38dcbb63d3fb241
https://doi.org/10.1101/2021.05.07.443159
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3
ICA512 RESP18 homology domain is a protein-condensing factor and insulin fibrillation inhibitor
Autor: Michele Solimena, Andreas Müller, Anke Sönmez, C. Wegbrod, Mario R. Ermácora, Pamela L. Toledo, Juha M. Torkko
Publikováno v: SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
J Biol Chem
Journal of Biological Chemistry
J. Biol. Chem. 294, 8564-8576 (2019)
Type 1 diabetes islet cell autoantigen 512 (ICA512/IA-2) is a tyrosine phosphatase–like intrinsic membrane protein involved in the biogenesis and turnover of insulin secretory granules (SGs) in pancreatic islet b-cells. Whereas its membrane-proxima
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db66c9075252d5f10df8413d95a2e922
http://sedici.unlp.edu.ar/handle/10915/107008
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6
Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes
Autor: Enrico Petretto, Mara Suleiman, Franco Filipponi, Lorella Marselli, Hassan Mziaut, Hans-Detlev Saeger, Andreas Dahl, Robin Liechti, Birgit Meyer-Puttlitz, Marius Distler, Anke Sönmez, C. Wegbrod, Katja Pfriem, Raphael Scharfmann, Sigurd Lenzen, Piero Marchetti, Afshan Siddiq, A. Friedrich, Bernard Thorens, Mark Ibberson, Daniel Margerie, Anne Jörns, Philippe Froguel, Everson Nogoceke, Mario Falchi, Florian Ehehalt, Michele Solimena, Aida Moreno-Moral, Manuela Kleeberg, Robert Grützmann, Frédéric Burdet, Anke M. Schulte, Ugo Boggi, Guy A. Rutter, Farooq Syed, Leonore Wigger, Klaus-Peter Knoch, Dorothée Sturm, Julia Parnis, Daniela Richter, Mathias Lesche, Gustavo B. Baretton, Ioannis Xenarios, Paolo Meda, Claes B. Wollheim, Jürgen Weitz, Krister Bokvist, Manon von Bulow, Marco Bugliani, Jörn Meinel, Ezio Bonifacio
Publikováno v: Diabetologia 61, 641–657 (2018)
Diabetologia
Diabetologia, vol. 61, no. 3, pp. 641-657
Diabetologia, Vol. 61, No 3 (2018) pp. 641-657
Aims/hypothesis Pancreatic islet beta cell failure causes type 2 diabetes in humans. To identify transcriptomic changes in type 2 diabetic islets, the Innovative Medicines Initiative for Diabetes: Improving beta-cell function and identification of di
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bed68b9192f383629adabf1feea42352
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=52600
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7
Akademický článek
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8
PTBP1 is required for glucose-stimulated cap-independent translation of insulin granule proteins and Coxsackieviruses in beta cells
Autor: A. Friedrich, Michele Solimena, Suchita Nath-Sain, Anke Sönmez, Klaus-Peter Knoch, C. Wegbrod, Antje Petzold, Mike Beck, Carla Münster, Merja Roivainen, Hendryk Schneider
Publikováno v: Molecular Metabolism
Glucose and GLP-1 stimulate not only insulin secretion, but also the post-transcriptional induction of insulin granule biogenesis. This process involves the nucleocytoplasmic translocation of the RNA binding protein PTBP1. Binding of PTBP1 to the 3
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ec003aaba9a2bcfcf903f6e25c89cd5
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9
cAMP-dependent phosphorylation of PTB1 promotes the expression of insulin secretory granule proteins in β cells
Autor: Hans-Detlev Saeger, Anke Altkrüger, Michele Solimena, Hendrik Bergert, Stephan Kersting, Melanie Jäger, Klaus-Peter Knoch, C. Wegbrod, Ronny Meisterfeld
Publikováno v: Cell Metabolism. 3(2):123-134
Summary Glucose stimulates the exocytosis of insulin secretory granules of pancreatic β cells. Granule stores are quickly refilled by activation of posttranscriptional mechanisms that enhance the biosynthesis of granule components. Rapid replacement
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ea22b6fb374524c6ab718fe70fb2842
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