Zobrazeno 1 - 10 of 83 pro vyhledávání: '"C. W. Boone"'
1
Oltipraz, a novel inhibitor of hepatitis B virus transcription through elevation of p53 protein
Autor: Shin-Lian Doong, G. J. Kelloff, Wei Jie Chi, J.-K. Lin, C. W. Boone, S.-Y. Lin-Shiau
Publikováno v: Carcinogenesis. 19:2133-2138
Molecular epidemiological studies of populations at high risk for liver cancer have shown that hepatitis B virus (HBV) and aflatoxin B1 exposures are two major risk factors for this disease. Oltipraz is currently being considered for clinical trial t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64c40525dce2ac1009db09af504f0f90
https://doi.org/10.1093/carcin/19.12.2133
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3
Quantitative nuclear morphometry by image analysis for prediction of recurrence of ductal carcinoma in situ of the breast
Autor: A, Hoque, S M, Lippman, I V, Boiko, E N, Atkinson, N, Sneige, A, Sahin, D M, Weber, S, Risin, M D, Lagios, R, Schwarting, W J, Colburn, K, Dhingra, M, Follen, G J, Kelloff, C W, Boone, W N, Hittelman
Publikováno v: Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 10(3)
Clinical management of ductal carcinoma in situ (DCIS) remains a challenge because significant proportions of patients experience recurrence after conservative surgical treatment. Unfortunately, it is difficult to prospectively identify, using object
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::27d378aad52439e86e4537e5bc23b7ce
https://pubmed.ncbi.nlm.nih.gov/11303595
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4
Chemoprevention with theaflavins of rat esophageal intraepithelial neoplasia quantitatively monitored by image tile analysis
Autor: C W, Boone, G D, Stoner, J V, Bacus, V, Kagan, M A, Morse, G J, Kelloff, J W, Bacus
Publikováno v: Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 9(11)
The objective of the study was to compare three methods of monitoring the inhibition by dietary theaflavins of N-nitrosomethylbenzylamine (NMBA)-induced rat esophageal intraepithelial neoplasia: the mean tile grade, measured by computer-assisted quan
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::38f7e9260f5e1ba9f188f2bf55709fe6
https://pubmed.ncbi.nlm.nih.gov/11097221
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5
Quantitative grading of rat esophageal carcinogenesis using computer-assisted image tile analysis
Autor: C W, Boone, G D, Stoner, J V, Bacus, V, Kagan, M A, Morse, G J, Kelloff, J W, Bacus
Publikováno v: Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 9(5)
Our objective was to grade, by computer-assisted quantitative image tile analysis, the intraepithelial neoplasia (also called dysplasia) that develops in esophagi of rats given N-nitrosomethybenzylamine (NMBA) for 5 weeks. To perform image tile analy
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0be1b30f96bc3f3b948cfc6d11dfd27a
https://pubmed.ncbi.nlm.nih.gov/10815694
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6
Endpoint markers for cancer chemoprevention trials derived from the lesion of precancer (intraepithelial neoplasia) measured by computer-assisted quantitative image analysis
Autor: C W, Boone, G J, Kelloff
Publikováno v: Journal of cellular biochemistry. Supplement. 34
Endpoint markers for cancer chemoprevention clinical trials are described that are developed from the morphological properties of the precancerous lesion of intraepithelial neoplasia itself, as measured by computer-assisted quantitative image analysi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1e193aa013ddc89026340ec09ff59360
https://pubmed.ncbi.nlm.nih.gov/10762017
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7
Perspectives on surrogate end points in the development of drugs that reduce the risk of cancer
Autor: G J, Kelloff, C C, Sigman, K M, Johnson, C W, Boone, P, Greenwald, J A, Crowell, E T, Hawk, L A, Doody
Publikováno v: Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 9(2)
This paper proposes a scientific basis and possible strategy for applying surrogate end points in chemopreventive drug development. The potential surrogate end points for cancer incidence described are both phenotypic (at the tissue, cellular, and mo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::513c2563bc853588d6f77e3b32be2dbf
https://pubmed.ncbi.nlm.nih.gov/10698472
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8
Image morphometric nuclear grading of intraepithelial neoplastic lesions with applications to cancer chemoprevention trials
Autor: J W, Bacus, C W, Boone, J V, Bacus, M, Follen, G J, Kelloff, V, Kagan, S M, Lippman
Publikováno v: Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 8(12)
A new image morphometric method of nuclear grading is described and assessed in the context of the evaluation of histological samples from ductal carcinoma in situ of the breast and cervical intraepithelial neoplasia. The method results in a continuo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6a9fd055763a5eadb9f2ab47fe76cef3
https://pubmed.ncbi.nlm.nih.gov/10613341
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9
Endpoint markers for clinical trials of chemopreventive agents derived from the properties of epithelial precancer (intraepithelial neoplasia) measured by computer-assisted image analysis
Autor: C W, Boone, G J, Kelloff
Publikováno v: Cancer surveys. 32
The Chemoprevention Branch, NCI, is supporting over 80 clinical trials of chemopreventive agents and has dozens of drugs under development. The structural and functional properties of epithelial precancer (also called preinvasive or IEN), such as inc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f56320d9a3f3c2a67f9682526d256884
https://pubmed.ncbi.nlm.nih.gov/10489626
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10
Protective action of plant polyphenols on radiation-induced chromatid breaks in cultured human cells
Autor: R, Parshad, K K, Sanford, F M, Price, V E, Steele, R E, Tarone, G J, Kelloff, C W, Boone
Publikováno v: Anticancer research. 18(5A)
The present study was performed to determine whether plant polyphenols can protect human cells against radiation-induced DNA damage manifested as chromatid breaks. Since each chromatid contains a single continuous molecule of double stranded DNA, chr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::20908ddb244062c47814800932af81f5
https://pubmed.ncbi.nlm.nih.gov/9858893
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