Výsledky vyhledávání - "C. W. Andrews"

Autor: Lawrence X. Yu, L Bennett, C W Andrews

Publikováno v: Pharmaceutical Research. 17:639-644

Purpose. The purpose of this investigation was to develop aquantitative structure-bioavailability relationship (QSBR) model for drugdiscovery and development.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::90cd6ebf38c6d34587050af319ece3f4
https://doi.org/10.1023/a:1007556711109

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Identification and characterization of mutations in hepatitis B virus resistant to lamivudine

Autor: C W Andrews, Lynn D. Condreay, Kathie-Anne Walters, Graham Tipples, David L.J. Tyrrell, Nathaniel A. Brown, Marchelle I. Allen, Manon Deslauriers

Publikováno v: Hepatology. 27:1670-1677

Cirrhosis and hepatocellular carcinoma occur as long-term complications of chronic hepatitis B virus (HBV) infection. Antiviral therapy is potentially a successful approach for the treatment of patients with HBV infection, which includes the nucleosi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f69a6ac7bf6b1b042b85c8091834c307
https://doi.org/10.1002/hep.510270628

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Mouse strain-dependent variation in the course and outcome of chlamydial genital tract infection is associated with differences in host response

Autor: W. Shymasani, Kim Kelly Laffoon, C. W. Andrews, Toni Darville, Roger G. Rank, L. R. Kishen

Publikováno v: Infection and Immunity. 65:3065-3073

Whether there is a pathogenic or protective outcome to chlamydial infection may be defined by the host response. We infected C57BL/6 (C57) and C3H/HeN (C3H) mice with the human biovar of Chlamydia trachomatis, serovar E, and, in select experiments, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6ee12f037dd3ce68c13cbf89eeb2fc8
https://doi.org/10.1128/iai.65.8.3065-3073.1997

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4-(Heteroarylthio)-2-biphenylyltetrazoles as Nonpeptide Angiotensin II Antagonists

Autor: C. L. Cowan, C. W. Andrews, Mark H. Norman, R. P. Steffen, F. L. M. Tang, H. D. Smith

Publikováno v: Journal of Medicinal Chemistry. 38:4670-4678

A series of 4-(heteroarylthio)-2-biphenylyltetrazoles was prepared, and the compounds were examined for their ability to displace [3H]AII from angiotensin II receptors. Analogues that exhibited significant receptor binding affinities at less than 10

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::125248df5ceafab023d666c5985b04ee
https://doi.org/10.1021/jm00023a006

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Endoscopic surveillance of Barrett’s esophagus

Autor: J. R. Benfield, John M. Streitz, V. F. Trastek, Ellis Fh, C. W. Andrews, D. B. Skinner

Publikováno v: The Journal of Thoracic and Cardiovascular Surgery. 105:383-388

Patients with Barrett’s esophagus are recognized as having a high risk of development of adenocarcinoma. Although endoscopic surveillance of these patients is commonly practiced, its benefits have not been proved. This study was undertaken to exami

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ed5094290addc1f19fda32f04f1b29bd
https://doi.org/10.1016/s0022-5223(19)34219-9

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A Comparison of the Conformations of the 5′-Triphosphates of Zidovudine (AZT) and Thymidine Bound to HIV-1 Reverse Transcriptase

Autor: C. W. Andrews, A. E. Aulabaugh, G.R. Painter

Publikováno v: Biochemical and Biophysical Research Communications. 191:1166-1171

Nuclear Overhauser effect experiments were performed at 500 MHz to determine the conformations of AZTTP and dTTP when bound to HIV-1 reverse transcriptase. The conformations of both ligands were found to be similar in the bound state. The orientation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::921566d02e5569c9894b3515d8f38248
https://doi.org/10.1006/bbrc.1993.1339

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