Memory strength gates the involvement of a CREB-dependent cortical fear engram in remote memory

Autor: Mariana R. Matos, Esther Visser, Ioannis Kramvis, Rolinka J. van der Loo, Titia Gebuis, Robbert Zalm, Priyanka Rao-Ruiz, Huibert D. Mansvelder, August B. Smit, Michel C. van den Oever

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)

Little is known about mechanisms that regulate the involvement of cortical engram cells in remote memory. Here, authors demonstrate that memory consolidation by mPFC engram cells requires CREB-mediated transcription, with the functionality of this ne

Externí odkaz: https://doaj.org/article/2dcc06a021f6409fbd0f338e392bb063

A Synaptic Framework for the Persistence of Memory Engrams

Autor: Priyanka Rao-Ruiz, Esther Visser, Miodrag Mitrić, August B. Smit, Michel C. van den Oever

Publikováno v: Frontiers in Synaptic Neuroscience, Vol 13 (2021)

The ability to store and retrieve learned information over prolonged periods of time is an essential and intriguing property of the brain. Insight into the neurobiological mechanisms that underlie memory consolidation is of utmost importance for our

Externí odkaz: https://doaj.org/article/5324abbaf5ad459bb7cd94066b3f618b

The CADM2 Gene and Behavior: A Phenome-Wide Scan in UK-Biobank

Autor: Joëlle A. Pasman, Zeli Chen, Dirk J. A. Smit, Jacqueline M. Vink, Michel C. Van Den Oever, Tommy Pattij, Taco J. De Vries, Abdel Abdellaoui, Karin J. H. Verweij

Publikováno v: Behavior Genetics, 52(4-5), 306-314. Springer US
Behavior Genetics, 52, 4, pp. 306-314
Behavior genetics, 52(4-5), 306-314. Springer New York
Pasman, J A, Chen, Z, Smit, D J A, Vink, J M, Van Den Oever, M C, Pattij, T, De Vries, T J, Abdellaoui, A & Verweij, K J H 2022, ' The CADM2 Gene and Behavior : A Phenome-Wide Scan in UK-Biobank ', Behavior Genetics, vol. 52, no. 4-5, pp. 306-314 . https://doi.org/10.1007/s10519-022-10109-8
Pasman, J A, Chen, Z, Smit, D J A, Vink, J M, van den Oever, M C, Pattij, T, de Vries, T J, Abdellaoui, A & Verweij, K J H 2022, ' The CADM2 Gene and Behavior : A Phenome-Wide Scan in UK-Biobank ', Behavior Genetics, vol. 52, no. 4-5, pp. 306-314 . https://doi.org/10.1007/s10519-022-10109-8
Behavior Genetics, 52(4-5), 306-314. Springer
Behavior Genetics, 52, 306-314
Behavior Genetics. Springer US

The cell adhesion molecule 2 (CADM2) gene has appeared among the top associations in a wide range of genome-wide association studies (GWASs). This study aims to: (1) examine how widespread the role of CADM2 is in behavioural traits, and (2) investiga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74d78ad2f9917ee70c8ffb4b842c45ca
https://research.vumc.nl/en/publications/de24dbb4-7124-43a8-9df1-0724380e0345

Glucocorticoids Promote Fear Generalization by Increasing the Size of a Dentate Gyrus Engram Cell Population

Autor: Harm J. Krugers, Niek Brosens, Nathalie Immerzeel, Sylvie L. Lesuis, Rolinka J. van der Loo, Miodrag Mitrić, Paul J. Lucassen, Michel C. van den Oever, Pascal Bielefeld, Steven A. Kushner, Carlos P. Fitzsimons

Publikováno v: Lesuis, S L, Brosens, N, Immerzeel, N, van der Loo, R J, Mitrić, M, Bielefeld, P, Fitzsimons, C P, Lucassen, P J, Kushner, S A, van den Oever, M C & Krugers, H J 2021, ' Glucocorticoids Promote Fear Generalization by Increasing the Size of a Dentate Gyrus Engram Cell Population ', Biological Psychiatry, vol. 90, no. 7, pp. 494-504 . https://doi.org/10.1016/j.biopsych.2021.04.010, https://doi.org/10.1016/j.biopsych.2021.04.010
Biological Psychiatry, 90(7), 494-504. Elsevier Inc.
Biological Psychiatry, 90(7), 494-504. Elsevier
Biological Psychiatry, 90(7), 494-504. Elsevier USA

BACKGROUND: Traumatic experiences, such as conditioned threat, are coded as enduring memories that are frequently subject to generalization, which is characterized by (re-) expression of fear in safe environments. However, the neurobiological mechani

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::983c04fa3ddc145da89ed28634f88143
https://research.vu.nl/en/publications/0adccf79-cfa2-46b3-b426-3b5f28761f98

A neural substrate of compulsive alcohol use

Autor: Esi, Domi, Li, Xu, Sanne, Toivainen, Anton, Nordeman, Francesco, Gobbo, Marco, Venniro, Yavin, Shaham, Robert O, Messing, Esther, Visser, Michel C, van den Oever, Lovisa, Holm, Estelle, Barbier, Eric, Augier, Markus, Heilig

Publikováno v: Science advances, 7(34):eabg9045. American Association for the Advancement of Science
Domi, E, Xu, L, Toivainen, S, Nordeman, A, Gobbo, F, Venniro, M, Shaham, Y, Messing, R O, Visser, E, Oever, M C V D, Holm, L, Barbier, E, Augier, E & Heilig, M 2021, ' A neural substrate of compulsive alcohol use ', Science Advances, vol. 7, no. 34, eabg9045 . https://doi.org/10.1126/sciadv.abg9045
Domi, E, Xu, L, Toivainen, S, Nordeman, A, Gobbo, F, Venniro, M, Shaham, Y, Messing, R O, Visser, E, van den Oever, M C, Holm, L, Barbier, E, Augier, E & Heilig, M 2021, ' A neural substrate of compulsive alcohol use ', Science advances, vol. 7, no. 34, eabg9045 . https://doi.org/10.1126/sciadv.abg9045
Science Advances

Inhibitory PKCδ-expressing neurons in the central nucleus of the amygdala promote compulsive alcohol use in rats.
Alcohol intake remains controlled in a majority of users but becomes “compulsive,” i.e., continues despite adverse consequence

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::00e15dc348a57e04873ab734b2452099
http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-178772