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Use of acetylcholine binding protein in the search for novel alpha7 nicotinic receptor ligands. In silico docking, pharmacological screening, and X-ray analysis

Autor: August B. Smit, Aldo Jongejan, René van Elk, Daniel Bertrand, Anastassis Perrakis, Sonia Bertrand, C. Ulens, Titia K. Sixma, Atilla Akdemir, Iwan J. P. de Esch, Rob Leurs

Publikováno v: Journal of Medicinal Chemistry, 52, 2372-2383. American Chemical Society
Ulens, C, Akdemir, A, Jongejan, A, van Elk, R, Bertrand, S, Perrakis, A, Leurs, R, Smit, A B, Sixma, T K, Bertrand, D & de Esch, I J P 2009, ' Use of acetylcholine binding protein in the search for novel alpha7 nicotinic receptor ligands. In silico docking, pharmacological screening, and X-ray analysis ', Journal of Medicinal Chemistry, vol. 52, pp. 2372-2383 . https://doi.org/10.1021/jm801400g

Acetylcholine binding protein (AChBP) is widely considered as a functional and structural homologue of the ligand binding domain of Cys-loop receptors. We report the use of AChBP as template to identify ligands for the nicotinic receptors (nAChRs). A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aae79e03b7735382f17f387f26cb271f
https://doi.org/10.1021/jm801400g

Structural determinants of selective alpha-conotoxin binding to a nicotinic acetylcholine receptor homolog AChBP

Autor: C. Ulens, Victor I. Tsetlin, Titia K. Sixma, August B. Smit, Patrick H.N. Celie, Ron C. Hogg, Daniel Bertrand

Publikováno v: Ulens, C, Hogg, R C, Celie, P H, Bertrand, D, Tsetlin, V, Smit, A B & Sixma, T K 2006, ' Structural determinants of selective alpha-conotoxin binding to a nicotinic acetylcholine receptor homolog AChBP ', Proceedings of the National Academy of Sciences of the United States of America, vol. 103, pp. 3615-3620 . https://doi.org/10.1073/pnas.0507889103
Proceedings of the National Academy of Sciences of the United States of America, 103, 3615-3620. National Acad Sciences

The nicotinic acetylcholine receptor (nAChR) is the prototype member of the superfamily of pentameric ligand-gated ion channels. How the extracellular ligand-binding domain coordinates selective binding of ligand molecules to different subtypes of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52ea269d4c705d4f446aa4c39db3555b
https://doi.org/10.1073/pnas.0507889103

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