Zobrazeno 1 - 10
of 135
pro vyhledávání: '"C. Tysoe"'
Autor:
Teresa, Brevini, Mailis, Maes, Gwilym J, Webb, Binu V, John, Claudia D, Fuchs, Gustav, Buescher, Lu, Wang, Chelsea, Griffiths, Marnie L, Brown, William E, Scott, Pehuén, Pereyra-Gerber, William T H, Gelson, Stephanie, Brown, Scott, Dillon, Daniele, Muraro, Jo, Sharp, Megan, Neary, Helen, Box, Lee, Tatham, James, Stewart, Paul, Curley, Henry, Pertinez, Sally, Forrest, Petra, Mlcochova, Sagar S, Varankar, Mahnaz, Darvish-Damavandi, Victoria L, Mulcahy, Rhoda E, Kuc, Thomas L, Williams, James A, Heslop, Davide, Rossetti, Olivia C, Tysoe, Vasileios, Galanakis, Marta, Vila-Gonzalez, Thomas W M, Crozier, Johannes, Bargehr, Sanjay, Sinha, Sara S, Upponi, Corrina, Fear, Lisa, Swift, Kourosh, Saeb-Parsy, Susan E, Davies, Axel, Wester, Hannes, Hagström, Espen, Melum, Darran, Clements, Peter, Humphreys, Jo, Herriott, Edyta, Kijak, Helen, Cox, Chloe, Bramwell, Anthony, Valentijn, Christopher J R, Illingworth, Bassam, Dahman, Dustin R, Bastaich, Raphaella D, Ferreira, Thomas, Marjot, Eleanor, Barnes, Andrew M, Moon, Alfred S, Barritt, Ravindra K, Gupta, Stephen, Baker, Anthony P, Davenport, Gareth, Corbett, Vassilis G, Gorgoulis, Simon J A, Buczacki, Joo-Hyeon, Lee, Nicholas J, Matheson, Michael, Trauner, Andrew J, Fisher, Paul, Gibbs, Andrew J, Butler, Christopher J E, Watson, George F, Mells, Gordon, Dougan, Andrew, Owen, Ansgar W, Lohse, Ludovic, Vallier, Fotios, Sampaziotis
Publikováno v:
Nature. 615:134-142
Preventing SARS-CoV-2 infection by modulating viral host receptors, such as angiotensin-converting enzyme 2 (ACE2)1, could represent a new chemoprophylactic approach for COVID-19 that complements vaccination2,3. However, the mechanisms that control t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3d1f48c490c312e0492b836b250c36f
https://doi.org/10.1038/s41586-022-05594-0
https://doi.org/10.1038/s41586-022-05594-0
Autor:
Brandon T. Wesley, Alexander D. B. Ross, Daniele Muraro, Zhichao Miao, Sarah Saxton, Rute A. Tomaz, Carola M. Morell, Katherine Ridley, Ekaterini D. Zacharis, Sandra Petrus-Reurer, Judith Kraiczy, Krishnaa T. Mahbubani, Stephanie Brown, Jose Garcia-Bernardo, Clara Alsinet, Daniel Gaffney, Dave Horsfall, Olivia C. Tysoe, Rachel A. Botting, Emily Stephenson, Dorin-Mirel Popescu, Sonya MacParland, Gary Bader, Ian D. McGilvray, Daniel Ortmann, Fotios Sampaziotis, Kourosh Saeb-Parsy, Muzlifah Haniffa, Kelly R. Stevens, Matthias Zilbauer, Sarah A. Teichmann, Ludovic Vallier
Publikováno v:
Nature Cell Biology. 24:1487-1498
The liver has been studied extensively due to the broad number of diseases affecting its vital functions. However, therapeutic advances have been hampered by the lack of knowledge concerning human hepatic development. Here, we addressed this limitati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2f2e9ea02987281a5813a196e29654f
https://doi.org/10.1038/s41556-022-00989-7
https://doi.org/10.1038/s41556-022-00989-7
Publikováno v:
Journal of Hepatology. 73:918-932
Summary Our insight into the pathogenesis of cholestatic liver disease remains limited, partly owing to challenges in capturing the multitude of factors that contribute to disease pathogenesis in vitro. Tissue engineering could address this challenge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccb51d2e7952e0a1787308dc09b5da56
https://doi.org/10.1016/j.jhep.2020.05.049
https://doi.org/10.1016/j.jhep.2020.05.049
Autor:
Olivia C. Tysoe, A Butler, Daniele Muraro, T. Brevini, Alfred Barritt, Sara Upponi, Gordon Dougan, Eleanor Barnes, R. E. Kuc, V. L. Mulcahy, Sally Forrest, Andrew Davenport, S. J. A. Buczacki, T. L. Williams, Ludovic Vallier, Mailis Maes, Paul Gibbs, S. Varankar, R. K. Gupta, Ansgar W. Lohse, George F. Mells, S. Baker, Christopher J.E. Watson, Andrew M. Moon, Kourosh Saeb-Parsy, P. Mlcochova, Sanjay Sinha, L. Swift, T. W. M. Crozier, M. Darvish-Damavandi, Susan E. Davies, Johannes Bargehr, M. Vila-Gonzalez, Gwilym J. Webb, William Gelson, F. Sampaziotis, Thomas Marjot, V. Galanakis, J. H. Lee, S. Dillon, Gareth Corbett
Publikováno v:
Oral.
Introduction The management of COVID19 is complicated by vaccine availability, the modest efficacy of existing treatments, and the potential for viral resistance. Therefore, there is a pressing need for new prophylactic and therapeutic agents. The vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac294d004b698ff6e4a55be518fa5174
https://doi.org/10.1136/gutjnl-2021-basl.7
https://doi.org/10.1136/gutjnl-2021-basl.7
Autor:
Olivia C. Tysoe, Andrew M. Moon, Paul Gibbs, Sally Forrest, Sanjay Sinha, Johannes Bargehr, Daniele Muraro, Sidney A Barritt, William Gelson, Gwilym J. Webb, Eleanor Barnes, Mailis Maes, Stephen Baker, Gareth Corbett, Thomas L Williams, Gordon Dougan, Vasileios Galanakis, Ravindra K. Gupta, Fotios Sampaziotis, Scott Dillon, Ludovic Vallier, Lisa Swift, Teresa Brevini, Andrew J. Butler, Mahnaz Darvish-Damavandi, Sara Upponi, Ansgar W. Lohse, George F. Mells, Kourosh Saeb-Parsy, Simon J.A. Buczacki, Marta Vila-Gonzalez, Victoria L. Mulcahy, Susan E. Davies, Sagar Varankar, Thomas Marjot, Petra Mlcochova, Christopher J.E. Watson, Anthony P. Davenport, Joo-Hyeon Lee, Thomas W M Crozier, Rhoda E. Kuc
Prevention of SARS-CoV-2 entry in cells through the modulation of viral host receptors, such as ACE2, could represent a new therapeutic approach complementing vaccination. However, the mechanisms controlling ACE2 expression remain elusive. Here, we i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67bbf5a5471abdb9a98cd836cdc4ceac
https://doi.org/10.1101/2021.06.06.446781
https://doi.org/10.1101/2021.06.06.446781
Autor:
Stuart Aitken, Helen V. Firth, Jeremy McRae, Mihail Halachev, Usha Kini, Michael J. Parker, Melissa M. Lees, Katherine Lachlan, Ajoy Sarkar, Shelagh Joss, Miranda Splitt, Shane McKee, Andrea H. Németh, Richard H. Scott, Caroline F. Wright, Joseph A. Marsh, Matthew E. Hurles, David R. FitzPatrick, T.W. Fitzgerald, S.S. Gerety, W.D. Jones, M. van Kogelenberg, D.A. King, J. McRae, K.I. Morley, V. Parthiban, S. Al-Turki, K. Ambridge, D.M. Barrett, T. Bayzetinova, S. Clayton, E.L. Coomber, S. Gribble, P. Jones, N. Krishnappa, L.E. Mason, A. Middleton, R. Miller, E. Prigmore, D. Rajan, A. Sifrim, A.R. Tivey, M. Ahmed, N. Akawi, R. Andrews, U. Anjum, H. Archer, R. Armstrong, M. Balasubramanian, R. Banerjee, D. Barelle, P. Batstone, D. Baty, C. Bennett, J. Berg, B. Bernhard, A.P. Bevan, E. Blair, M. Blyth, D. Bohanna, L. Bourdon, D. Bourn, A. Brady, E. Bragin, C. Brewer, L. Brueton, K. Brunstrom, S.J. Bumpstead, D.J. Bunyan, J. Burn, J. Burton, N. Canham, B. Castle, K. Chandler, S. Clasper, J. Clayton-Smith, T. Cole, A. Collins, M.N. Collinson, F. Connell, N. Cooper, H. Cox, L. Cresswell, G. Cross, Y. Crow, P.M. D’Alessandro, T. Dabir, R. Davidson, S. Davies, J. Dean, C. Deshpande, G. Devlin, A. Dixit, A. Dominiczak, C. Donnelly, D. Donnelly, A. Douglas, A. Duncan, J. Eason, S. Edkins, S. Ellard, P. Ellis, F. Elmslie, K. Evans, S. Everest, T. Fendick, R. Fisher, F. Flinter, N. Foulds, A. Fryer, B. Fu, C. Gardiner, L. Gaunt, N. Ghali, R. Gibbons, S.L. Gomes Pereira, J. Goodship, D. Goudie, E. Gray, P. Greene, L. Greenhalgh, L. Harrison, R. Hawkins, S. Hellens, A. Henderson, E. Hobson, S. Holden, S. Holder, G. Hollingsworth, T. Homfray, M. Humphreys, J. Hurst, S. Ingram, M. Irving, J. Jarvis, L. Jenkins, D. Johnson, D. Jones, E. Jones, D. Josifova, S. Joss, B. Kaemba, S. Kazembe, B. Kerr, U. Kini, E. Kinning, G. Kirby, C. Kirk, E. Kivuva, A. Kraus, D. Kumar, K. Lachlan, W. Lam, A. Lampe, C. Langman, M. Lees, D. Lim, G. Lowther, S.A. Lynch, A. Magee, E. Maher, S. Mansour, K. Marks, K. Martin, U. Maye, E. McCann, V. McConnell, M. McEntagart, R. McGowan, K. McKay, S. McKee, D.J. McMullan, S. McNerlan, S. Mehta, K. Metcalfe, E. Miles, S. Mohammed, T. Montgomery, D. Moore, S. Morgan, A. Morris, J. Morton, H. Mugalaasi, V. Murday, L. Nevitt, R. Newbury-Ecob, A. Norman, R. O’Shea, C. Ogilvie, S. Park, M.J. Parker, C. Patel, J. Paterson, S. Payne, J. Phipps, D.T. Pilz, D. Porteous, N. Pratt, K. Prescott, S. Price, A. Pridham, A. Proctor, H. Purnell, N. Ragge, J. Rankin, L. Raymond, D. Rice, L. Robert, E. Roberts, G. Roberts, J. Roberts, P. Roberts, A. Ross, E. Rosser, A. Saggar, S. Samant, R. Sandford, A. Sarkar, S. Schweiger, C. Scott, R. Scott, A. Selby, A. Seller, C. Sequeira, N. Shannon, S. Sharif, C. Shaw-Smith, E. Shearing, D. Shears, I. Simonic, D. Simpkin, R. Singzon, Z. Skitt, A. Smith, B. Smith, K. Smith, S. Smithson, L. Sneddon, M. Splitt, M. Squires, F. Stewart, H. Stewart, M. Suri, V. Sutton, G.J. Swaminathan, E. Sweeney, K. Tatton-Brown, C. Taylor, R. Taylor, M. Tein, I.K. Temple, J. Thomson, J. Tolmie, A. Torokwa, B. Treacy, C. Turner, P. Turnpenny, C. Tysoe, A. Vandersteen, P. Vasudevan, J. Vogt, E. Wakeling, D. Walker, J. Waters, A. Weber, D. Wellesley, M. Whiteford, S. Widaa, S. Wilcox, D. Williams, N. Williams, G. Woods, C. Wragg, M. Wright, F. Yang, M. Yau, N.P. Carter, M. Parker, H.V. Firth, D.R. FitzPatrick, C.F. Wright, J.C. Barrett, M.E. Hurles
Publikováno v:
American Journal of Human Genetics
Aitken, J, Firth, H V, McRae, J, Halachev, M, Kini, U, Parker, M J, Lees, M M, Lachlan, K, Sarkar, A, Joss, S, Splitt, M, McKee, S, Németh, A H, Scott, R H, Wright, C F, Marsh, J, Hurles, M E, FitzPatrick, D 2019, ' Finding Diagnostically Useful Patterns in Quantitative Phenotypic Data ', American Journal of Human Genetics . https://doi.org/10.1016/j.ajhg.2019.09.015
Aitken, J, Firth, H V, McRae, J, Halachev, M, Kini, U, Parker, M J, Lees, M M, Lachlan, K, Sarkar, A, Joss, S, Splitt, M, McKee, S, Németh, A H, Scott, R H, Wright, C F, Marsh, J, Hurles, M E, FitzPatrick, D 2019, ' Finding Diagnostically Useful Patterns in Quantitative Phenotypic Data ', American Journal of Human Genetics . https://doi.org/10.1016/j.ajhg.2019.09.015
Trio-based whole-exome sequence (WES) data have established confident genetic diagnoses in ∼40% of previously undiagnosed individuals recruited to the Deciphering Developmental Disorders (DDD) study. Here we aim to use the breadth of phenotypic inf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8438162f307fa6cb5836ae7a28494148
https://doi.org/10.1016/j.ajhg.2019.09.015
https://doi.org/10.1016/j.ajhg.2019.09.015
Autor:
Matthias Zilbauer, Olivia C. Tysoe, Daniele Muraro, Ludovic Vallier, Carola M. Morell, Nicholas R.F. Hannan, Stuart J. Forbes, Samantha G. Tilson, Richard L. Gieseck, Thomas A. Wynn, Simone E. Adams, Rute A. Tomaz, Brandon T Wesley, Wei-Yu Lu, Judith Kraiczy, John R. Ferdinand, Kourosh Saeb-Parsy, Gabriel C. Oniscu, Alexander Ross, Casey A. Rimland, Francisco Otaizo-Carrasquero, Nikitas Georgakopoulos, Timothy G. Myers, Fotios Sampaziotis
Publikováno v:
Hepatology
Rimland, C A, Tilson, S G, Morell, C M, Tomaz, R A, Lu, W-Y, Adams, S E, Georgakopoulos, N, Otaizo-Carrasquero, F, Myers, T G, Ferdinand, J R, Gieseck, R L, Sampaziotis, F, Tysoe, O C, Wesley, B, Muraro, D, Oniscu, G C, Hannan, N R, Forbes, S J, Saeb-Parsy, K, Wynn, T A & Vallier, L 2020, ' Regional differences in human biliary tissues and corresponding in vitro derived organoids ', Hepatology . https://doi.org/10.1002/hep.31252
Hepatology (Baltimore, Md.)
Rimland, C A, Tilson, S G, Morell, C M, Tomaz, R A, Lu, W-Y, Adams, S E, Georgakopoulos, N, Otaizo-Carrasquero, F, Myers, T G, Ferdinand, J R, Gieseck, R L, Sampaziotis, F, Tysoe, O C, Wesley, B, Muraro, D, Oniscu, G C, Hannan, N R, Forbes, S J, Saeb-Parsy, K, Wynn, T A & Vallier, L 2020, ' Regional differences in human biliary tissues and corresponding in vitro derived organoids ', Hepatology . https://doi.org/10.1002/hep.31252
Hepatology (Baltimore, Md.)
Background and aims Organoids provide a powerful system to study epithelia in vitro. Recently, this approach was applied successfully to the biliary tree, a series of ductular tissues responsible for the drainage of bile and pancreatic secretions. Mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9726cf8011fd07478f790d0cdca21a08
Akademický článek
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Autor:
Sanjay Sinha, Victoria L. Mulcahy, William Gelson, Kourosh Saeb-Parsy, Brandon T Wesley, Sarah A. Teichmann, Laure Gambardella, Timothy E. Beach, Sharayne Robinson, Michael P. Murphy, Paul Gibbs, Stephanie Brown, Richard L. Gieseck, Peter C. Humphreys, Corrina Fear, Anna Osnato, Krishnaa T. Mahbubani, Gareth Corbett, Irum Amin, Olivia C. Tysoe, Daniele Muraro, Christopher J.E. Watson, Espen Melum, Daniel Ortmann, Andrew J. Butler, George F. Mells, Teresa Brevini, Keziah Crick, Sara Upponi, Fotios Sampaziotis, Susan E. Davies, Teik Choon See, Giovanni Canu, Stephen J. Sawiak, Jose Garcia-Bernardo, Edmund Godfrey, Ludovic Vallier, N.L. Berntsen, Lisa Swift, Johannes Bargehr
Publikováno v:
Science (New York, N.Y.). 371(6531)
Organoids regenerate human bile ducts Bile ducts carry bile from the liver and gall bladder to the small intestine, where it aids digestion. Cholangiocytes are epithelial cells that line bile ducts and modify bile as its transported through the bilia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f2e06061f52c139f9983e0ff94683d5
https://pubmed.ncbi.nlm.nih.gov/34416748
https://pubmed.ncbi.nlm.nih.gov/34416748
Autor:
Ludovic Vallier, Krishnaa T. Mahbubani, Espen Melum, Alexander W. Justin, Si Emma Chen, Olivia C. Tysoe, Hajer Zedira, Teresa Brevini, Athina E. Markaki, Anna Katharina Frank, Kourosh Saeb-Parsy, Fotios Sampaziotis
Publikováno v:
Nature Protocols
Pediatric liver transplantation is often required as a consequence of biliary disorders because of the lack of alternative treatments for repairing or replacing damaged bile ducts. To address the lack of availability of pediatric livers suitable for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a66844d20944107d151c35930937f4c
https://www.repository.cam.ac.uk/handle/1810/293672
https://www.repository.cam.ac.uk/handle/1810/293672