A pilot of the feasibility and usefulness of an aged obese model for use in stroke research [version 1; peer review: 2 approved]

Autor: Annastazia E. Learoyd, Ryan Calmus, Chelsea N. Cunningham, Tim J. England, Tracy D. Farr, Kevin C.F. Fone, David A. Kendall, Saoirse E. O’Sullivan, Rebecca C. Trueman

Publikováno v: Wellcome Open Research, Vol 6 (2021)

Background: Animal models of stroke have been criticised as having poor predictive validity, lacking risk factors prevalent in an aging population. This pilot study examined the development of comorbidities in a combined aged and high-fat diet model,

Externí odkaz: https://doaj.org/article/6d17c5da6d754bc2a211303e3f26d30a

Glyceryl trinitrate for the treatment of ischaemic stroke: Determining efficacy in rodent and ovine species for enhanced clinical translation

Autor: Ingo Schiessl, Anna V. Leonard, Stuart M. Allan, Philip M.W. Bath, Tracy D. Farr, Renée J. Turner, Annastazia E. Learoyd, Annabel J Sorby-Adams, Fiona Burrows, Rebecca C. Trueman

Publikováno v: Sorby-Adams, A J, Learoyd, A E, Bath, P M, Burrows, F, Farr, T D, Leonard, A V, Schiessl, I, Allan, S M, Turner, R J & Trueman, R C 2021, ' Glyceryl trinitrate for the treatment of ischaemic stroke: Determining efficacy in rodent and ovine species for enhanced clinical translation ', Journal of Cerebral Blood Flow & Metabolism . https://doi.org/10.1177/0271678X211018901
Journal of Cerebral Blood Flow & Metabolism

Hypertension is a leading risk factor for death and dependency after ischaemic stroke. However, administering anti-hypertensive medications post-stroke remains contentious with concerns regarding deleterious effects on cerebral blood flow and infarct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f03f6fcfd3df6701ad442d14e5621f5
https://doi.org/10.1177/0271678x211018901

Brownfield Sites as Hot Spots of Plant Diversity

Autor: Ian C. Trueman, Barbara Tokarska-Guzik, Eleanor V.J. Cohn

Publikováno v: Green Scenarios: Mining Industry Responses to Environmental Challenges of the Anthropocene Epoch ISBN: 9781003271604

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aebac73ba0afc358fff2239d756225a2
https://doi.org/10.1201/9781003271604-8

Long-Term Connectome Analysis Reveals Reshaping of Visual, Spatial Networks in a Model With Vascular Dementia Features

Autor: Gerard R. Hall, Philipp Boehm-Sturm, Ulrich Dirnagl, Carsten Finke, Marco Foddis, Christoph Harms, Stefan Paul Koch, Joseph Kuchling, Christopher R. Madan, Susanne Mueller, Celeste Sassi, Stamatios N. Sotiropoulos, Rebecca C. Trueman, Marcus D. Wallis, Ferah Yildirim, Tracy D. Farr

Publikováno v: Stroke 53(5), 1735-1745 (2022). doi:10.1161/STROKEAHA.121.036997

Background: Connectome analysis of neuroimaging data is a rapidly expanding field that offers the potential to diagnose, characterize, and predict neurological disease. Animal models provide insight into biological mechanisms that underpin disease, b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::409df5c4dd97591628cb1e62574f88f6
https://pubmed.ncbi.nlm.nih.gov/35105183

A pilot of the feasibility and usefulness of an aged obese model for use in stroke research

Autor: Kevin C. F. Fone, Tracy D. Farr, Timothy J. England, Ryan Calmus, Saoirse E. O'Sullivan, Chelsea N Cunningham, David A. Kendall, Annastazia E. Learoyd, Rebecca C. Trueman

Publikováno v: Wellcome Open Research

Background: Animal models of stroke have been criticised as having poor predictive validity, lacking risk factors prevalent in an aging population. This pilot study examined the development of comorbidities in a combined aged and high-fat diet model,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c4418a5200ce9b60fa82ec7d5540de8
https://pubmed.ncbi.nlm.nih.gov/34095511