Zobrazeno 1 - 10
of 36
pro vyhledávání: '"C. Tony Liu"'
Autor:
Sang Hu Kim, Luke Steere, Yong-Kang Zhang, Cari McGregor, Chris Hahne, Yasheen Zhou, Chunliang Liu, Yan Cai, Haibo Zhou, Xuefei Chen, Emily Puumala, Dustin Duncan, Gerard D. Wright, C. Tony Liu, Luke Whitesell, Leah E. Cowen
Publikováno v:
ACS Chemical Biology. 17:1343-1350
With resistance to current agricultural fungicides rising, a great need has emerged for new antifungals with unexploited targets. In response, we report a novel series of diazaborines with potent activity against representative fungal plant pathogens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b853e3829ea52ec1a4310147951c4a9
https://doi.org/10.1021/acschembio.2c00257
https://doi.org/10.1021/acschembio.2c00257
Autor:
Leah E. Cowen, Yasheen Zhou, Luke Whitesell, Yong-Kang Zhang, Sang Hu Kim, Cari McGregor, Brittany H. Frederick, Chunliang Liu, C. Tony Liu, Luke Steere
Publikováno v:
ACS chemical biology. 15(7)
Fungal pathogens pose an increasing threat to global food security through devastating effects on staple crops and contamination of food supplies with carcinogenic toxins. Widespread deployment of agricultural fungicides has increased crop yields but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fb192de3c6f87a44533a4cde4e4eeb7
https://pubmed.ncbi.nlm.nih.gov/32573189
https://pubmed.ncbi.nlm.nih.gov/32573189
Autor:
Luke Whitesell, Luke Steere, Musheng Xu, Brittany H. Frederick, Sang Hu Kim, C. Tony Liu, Chunliang Liu, Yong-Kang Zhang, Cari McGregor, Haibo Zhou, Leah E. Cowen, Yasheen Zhou, Timothy Pastoor, Yan Cai, Jiangong Wang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 43:128089
Several boron-containing small molecules have been approved by the US FDA to treat human diseases. We explored potential applications of boron-containing compounds in modern agriculture by pursuing multiple research and development programs. Here, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b333be7917b378479b6afd23df453adb
https://doi.org/10.1016/j.bmcl.2021.128089
https://doi.org/10.1016/j.bmcl.2021.128089
Publikováno v:
Accounts of Chemical Research
CONSPECTUS: Enzymes are essential for all living organisms, and their effectiveness as chemical catalysts has driven more than a half century of research seeking to understand the enormous rate enhancements they provide. Nevertheless, a complete unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f000da57da9cef31d475fcd06d6efd9
http://europepmc.org/articles/PMC4334233
http://europepmc.org/articles/PMC4334233
Autor:
Joshua P. Layfield, Sharon Hammes-Schiffer, Amnon Kohen, Kevin Francis, C. Tony Liu, Xinyi Huang, Stephen J. Benkovic
Publikováno v:
Proceedings of the National Academy of Sciences. 111:18231-18236
The reaction catalyzed by Escherichia coli dihydrofolate reductase (ecDHFR) has become a model for understanding enzyme catalysis, and yet several details of its mechanism are still unresolved. Specifically, the mechanism of the chemical step, the hy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2b67c723a97c012ee809996d9a0e219
https://doi.org/10.1073/pnas.1415940111
https://doi.org/10.1073/pnas.1415940111
Publikováno v:
Bioorganic & Medicinal Chemistry. 22:4462-4473
Benzoxaboroles have garnered much attention in recent years due to their diverse applications in bio-sensing technology, material science, and therapeutic intervention. Part of the reason arises from the benzoxaboroles' unique chemical properties, es
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6ed55d7ba9b5e2b4136e8d889ba8837
https://doi.org/10.1016/j.bmc.2014.04.065
https://doi.org/10.1016/j.bmc.2014.04.065
Autor:
John B. Asbury, Jarrod B. French, C. Tony Liu, Philip Hanoian, Stephen J. Benkovic, Robert J. Stewart, Joshua P. Layfield, Sharon Hammes-Schiffer
Publikováno v:
Journal of the American Chemical Society
Electrostatic interactions play an important role in enzyme catalysis by guiding ligand binding and facilitating chemical reactions. These electrostatic interactions are modulated by conformational changes occurring over the catalytic cycle. Herein,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f6865e272352c8ddf9c6e95186b3854
https://doi.org/10.1021/ja5038947
https://doi.org/10.1021/ja5038947
Autor:
C. Tony Liu, Stephen J. Benkovic
Publikováno v:
Journal of the American Chemical Society. 135:14544-14547
Post-translational redox generation of cysteine-sulfenic acids (Cys-SOH) functions as an important reversible regulatory mechanism for many biological functions, such as signal transduction, balancing cellular redox states, catalysis, and gene transc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9784f1cd46fab153d9185d151a1dc08b
https://doi.org/10.1021/ja407628a
https://doi.org/10.1021/ja407628a
Autor:
Thomas H. Pringle, Stephen J. Benkovic, C. Tony Liu, Jarrod B. French, Sharon Hammes-Schiffer, Philip Hanoian
Publikováno v:
Proceedings of the National Academy of Sciences. 110:10159-10164
With the rapidly growing wealth of genomic data, experimental inquiries on the functional significance of important divergence sites in protein evolution are becoming more accessible. Here we trace the evolution of dihydrofolate reductase (DHFR) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89c6e1406d12628149dac65ad9c733de
https://doi.org/10.1073/pnas.1307130110
https://doi.org/10.1073/pnas.1307130110
Publikováno v:
Inorganic Chemistry. 51:3846-3854
The cleavage of a set of phosphate mono-, di-, and triesters having a Cu(II)-complexed 2-phenanthrolyl group at the ortho-position of a departing phenoxide was studied in water and ethanol. Experimentally observed pH/rate profiles, solvent deuterium
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9fc0e85e4ce1945db1151a259c8c96a
https://doi.org/10.1021/ic300059e
https://doi.org/10.1021/ic300059e