Zobrazeno 1 - 10
of 19
pro vyhledávání: '"C. Thomas G. Appleton"'
Autor:
Holly T. Philpott, Ryan Pinto, C. Thomas G. Appleton, Brent A. Lanting, Dominique Arsenault, Trevor B. Birmingham, Yayuan Zhu, Codie A. Primeau
Publikováno v:
The Journal of Rheumatology. 49:89-97
ObjectiveTo examine the association between ultrasound (US)-detected knee inflammation and intermittent and constant pain experiences in patients with knee osteoarthritis (OA).MethodsParticipants with radiographically early-stage (Kellgren-Lawrence a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7866bc5f43050d406609eb2c2a38fd83
https://doi.org/10.3899/jrheum.210285
https://doi.org/10.3899/jrheum.210285
Autor:
Robert J. Petrella, Dianne Bryant, J. Kevin Shoemaker, Codie A. Primeau, Emilie Woehrle, Hayden F Atkinson, Frank Beier, Michaela C.M. Khan, Trevor B. Birmingham, Baraa K. Al-Khazraji, Michael J Lukacs, Jenna M. Schulz, Bryn O. Zomar, C. Thomas G. Appleton
Publikováno v:
Bone and Joint Institute
Physiology and Pharmacology Publications
Physiology and Pharmacology Publications
ObjectivesWe systemically reviewed published studies that evaluated aerobic exercise interventions in patients with knee osteoarthritis (OA) to: (1) report the frequency, intensity, type and time (FITT) of exercise prescriptions and (2) quantify the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f724a0d30e36469d4d165b9b6b7f3f94
https://doi.org/10.1136/bjsports-2018-100231
https://doi.org/10.1136/bjsports-2018-100231
Autor:
Codie A. Primeau, C. Thomas G. Appleton, Trevor B. Birmingham, J. Robert Giffin, Kristyn M. Leitch
Publikováno v:
Clinics in Sports Medicine. 38:471-482
Degenerative medial meniscal tears (DMMTs) are a common feature of early knee osteoarthritis (OA). Varus alignment is a strong risk factor for medial compartment knee OA and its progression. We propose that high tibial osteotomy (HTO) should be consi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::132383ba53dab357008640129b17bfc1
https://doi.org/10.1016/j.csm.2019.02.010
https://doi.org/10.1016/j.csm.2019.02.010
Autor:
Tony Nguyen, Frank Beier, Elizabeth R. Gillies, C. Thomas G. Appleton, Ian J. Villamagna, Xueli Mei
Publikováno v:
Chemistry Publications
Osteoarthritis (OA) is a leading cause of chronic disability. It is a progressive disease, involving pathological changes to the entire joint, resulting in joint pain, stiffness, swelling, and loss of mobility. There is currently no disease-modifying
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c38a6dc1f8c8f04eb3ea46708a94925f
https://ir.lib.uwo.ca/chempub/187
https://ir.lib.uwo.ca/chempub/187
Publikováno v:
Arthritis & Rheumatology. 67:2691-2701
Objective Transforming growth factor α (TGFα) is increased in osteoarthritic (OA) cartilage in rats and humans and modifies chondrocyte phenotype. CCL2 is increased in OA cartilage and stimulates proteoglycan loss. This study was undertaken to test
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc4b4b2098eb8b147e07a0e9e1e69d7e
https://doi.org/10.1002/art.39255
https://doi.org/10.1002/art.39255
Publikováno v:
Paediatrics Publications
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adfe5a883b82b5c7fefa85d3649352b4
https://ir.lib.uwo.ca/context/paedpub/article/1673/viewcontent/17.255.pdf
https://ir.lib.uwo.ca/context/paedpub/article/1673/viewcontent/17.255.pdf
Autor:
C. Thomas G. Appleton
Publikováno v:
Bone and Joint Institute
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47aa2a29bad5aff092ebae66eccd8456
https://pubmed.ncbi.nlm.nih.gov/28223124
https://pubmed.ncbi.nlm.nih.gov/28223124
Publikováno v:
Journal of Orthopaedic Research. 30:1391-1397
Previously, our lab identified transforming growth factor-alpha (TGFα) as a novel factor involved in osteoarthritis (OA) in a surgical model of the disease. In the same study, we also observed increased transcript levels for endothelin receptor A (E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bce437560dd1b583d07dce9beb15d328
https://doi.org/10.1002/jor.22099
https://doi.org/10.1002/jor.22099
Autor:
Denise L. Cecil, C. Thomas G. Appleton, Frank Beier, John S. Mort, Alison M. Bendele, Monika Polewski, Robert Terkeltaub, Ann Marie Schmidt
Publikováno v:
Bone and Joint Institute
Multiple inflammatory mediators in osteoarthritis (OA) cartilage, including S100/calgranulin ligands of receptor for advanced glycation end products (RAGE), promote chondrocyte hypertrophy, a differentiation state associated with matrix catabolism. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a480f113778f6efd72a149678e730470
https://doi.org/10.4049/jimmunol.0803603
https://doi.org/10.4049/jimmunol.0803603
Autor:
Glyn D. Palmer, Daniel B. Rifkin, Mandar Dave, H. Al-Mussawir, Cristina C. Teixeira, Steven B. Abramson, Mukundan Attur, Frank Beier, C. Thomas G. Appleton
Publikováno v:
Bone and Joint Institute
In osteoarthritis (OA) articular chondrocytes undergo phenotypic changes culminating in the progressive loss of cartilage from the joint surface. The molecular mechanisms underlying these changes are poorly understood. Here we report enhanced (∼7-f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5300c9fb0f18e419edbc905ccf9c7a5
https://doi.org/10.1096/fj.08-114363
https://doi.org/10.1096/fj.08-114363