Zobrazeno 1 - 10
of 31
pro vyhledávání: '"C. Thomas Appleton"'
Autor:
Garth Blackler, Yue Lai-Zhao, Joseph Klapak, Holly T. Philpott, Kyle K. Pitchers, Andrew R. Maher, Benoit Fiset, Logan A. Walsh, Elizabeth R. Gillies, C. Thomas Appleton
Publikováno v:
Arthritis Research & Therapy, Vol 26, Iss 1, Pp 1-15 (2024)
Abstract Background Pain from osteoarthritis (OA) is one of the top causes of disability worldwide, but effective treatment is lacking. Nociceptive factors are released by activated synovial macrophages in OA, but depletion of synovial macrophages pa
Externí odkaz:
https://doaj.org/article/0940f57f8f3a45eebcbb4ee9caf19d39
Autor:
Arundhasa Chandrabalan, Andrew Firth, Robert B. Litchfield, C. Thomas Appleton, Alan Getgood, Rithwik Ramachandran
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Osteoarthritis (OA) is the most prevalent joint disorder with increasing worldwide incidence. Mechanistic insights into OA pathophysiology are evolving and there are currently no disease-modifying OA drugs. An increase in protease activity i
Externí odkaz:
https://doaj.org/article/bbf254d69257457aba4c57cc25311c13
Autor:
Robert Dima, Trevor B. Birmingham, Holly T. Philpott, Dianne Bryant, Aaron Fenster, C. Thomas Appleton
Publikováno v:
Osteoarthritis and Cartilage Open, Vol 5, Iss 2, Pp 100356- (2023)
Objective: Effusion-synovitis is related to pain and progression in knee osteoarthritis (OA), but current gold standard ultrasound (US) measures are limited to semi-quantitative grading of joint distension or 1-dimensional thickness measures. A novel
Externí odkaz:
https://doaj.org/article/dafe18f8e6dd429c9ed04ca6b800b2d5
Autor:
Caleigh E. Bourdon, Zachary J. Koudys, Brent A. Lanting, C. Thomas Appleton, Jonathan D. Thiessen, Matthew G. Teeter
Publikováno v:
European Journal of Hybrid Imaging, Vol 6, Iss 1, Pp 1-11 (2022)
Abstract Background Positron emission tomography (PET) in combination with magnetic resonance imaging (MRI) could allow inflammatory complications near total knee arthroplasty (TKA) to be studied early in their development. However, attenuation of th
Externí odkaz:
https://doaj.org/article/4aea4a777bb04be59d4bfbde4275b1b1
Autor:
Holly T. Philpott, Trevor B. Birmingham, Benoit Fiset, Logan A. Walsh, Mitchell C. Coleman, Cheryle A. Séguin, C. Thomas Appleton
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Synovium is critical for maintaining joint homeostasis and may contribute to mechanobiological responses during joint movement. We investigated mechanobiological responses of whole synovium from patients with late-stage knee osteoarthritis (
Externí odkaz:
https://doaj.org/article/6b80484a512d4705b9168a98dd4089d7
Autor:
Emily U. Sodhi, Holly T. Philpott, McKenzie M. Carter, Trevor B. Birmingham, C. Thomas Appleton
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
PurposeSynovial inflammation in knee osteoarthritis (OA) causes disorganized synovial angiogenesis and complement activation in synovial fluid, but links between complement and synovial microvascular pathology have not been established. Since complem
Externí odkaz:
https://doaj.org/article/963f751f9f414682a38d7975534a8311
Autor:
Sezgin Sahin, Micol Romano, Ferhat Guzel, David Piskin, Dimitri Poddighe, Siren Sezer, Ozgur Kasapcopur, C. Thomas Appleton, Ilker Yilmaz, Erkan Demirkaya
Publikováno v:
Life, Vol 12, Iss 5, p 631 (2022)
Cardiovascular disease (CVD) remains underestimated in familial Mediterranean fever-associated AA amyloidosis (FMF-AA). We aimed to compare early markers of endothelial dysfunction and atherosclerosis in FMF-AA with a homozygous M694V mutation (Group
Externí odkaz:
https://doaj.org/article/09a68ce2277c4bab97129db2a5920061
Autor:
Luigi Del Sordo, Garth B. Blackler, Holly T. Philpott, Jared Riviere, Lakshman Gunaratnam, Bryan Heit, C. Thomas Appleton
Publikováno v:
Arthritis & Rheumatology. 75:685-696
Osteoarthritis (OA) exposes all joint tissues to physiologic stresses, increasing the need to clear apoptotic cells from tissues including the synovium. Our objectives were to assess the burden of apoptotic cells in synovial tissue in patients with l
Autor:
Jean W. Liew, Lauren K. King, Armaghan Mahmoudian, Qiuke Wang, Hayden F. Atkinson, David B. Flynn, C. Thomas Appleton, Martin Englund, Ida K. Haugen, L. Stefan Lohmander, Jos Runhaar, Tuhina Neogi, Gillian Hawker
Publikováno v:
Osteoarthritis and Cartilage.
Autor:
Garth Blackler, Yue Lai-Zhao, Joseph Klapak, Holly T. Philpott, Kyle K. Pitchers, Andrew R. Maher, Benoit Fiset, Logan A. Walsh, Elizabeth R. Gillies, C. Thomas Appleton
It has been suggested that synovial macrophages mediate nociceptive signals in knee osteoarthritis (OA) but the underlying mechanisms are unknown. Our objectives were to investigate the role of synovial macrophages and their activation via signal tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ba0f4919d490e3e7cfb1e42491d725c
https://doi.org/10.1101/2023.04.25.538261
https://doi.org/10.1101/2023.04.25.538261