Galectin-2 induces a proinflammatory, anti-arteriogenic phenotype in monocytes and macrophages.

Autor: Cansu Yıldırım, Daphne Y S Vogel, Maurits R Hollander, Josefien M Baggen, Ruud D Fontijn, Sylvia Nieuwenhuis, Anouk Haverkamp, Margreet R de Vries, Paul H A Quax, Juan J Garcia-Vallejo, Anja M van der Laan, Christine D Dijkstra, Tineke C T M van der Pouw Kraan, Niels van Royen, Anton J G Horrevoets

Publikováno v: PLoS ONE, Vol 10, Iss 4, p e0124347 (2015)

Galectin-2 is a monocyte-expressed carbohydrate-binding lectin, for which increased expression is genetically determined and associated with decreased collateral arteriogenesis in obstructive coronary artery disease patients. The inhibiting effect of

Externí odkaz: https://doaj.org/article/34df385d7d7646b7a091459c3970011c

The emerging role of galectins in cardiovascular disease

Autor: Niels van Royen, Maurits R. Hollander, Matthijs F. Jansen, Nina W. van der Hoeven, Anton J.G. Horrevoets, Paul F. Teunissen, Cansu Yıldırım, Tineke C. T. M. van der Pouw Kraan

Publikováno v: Vascular Pharmacology, 81, 31-41. Elsevier Inc.
van der Hoeven, N W, Hollander, M R, Yildirim, C, Jansen, M F, Teunissen, P F, Horrevoets, A, van der Pouw Kraan, T & van Royen, N 2016, ' The emerging role of galectins in cardiovascular disease ', Vascular Pharmacology, vol. 81, pp. 31-41 . https://doi.org/10.1016/j.vph.2016.02.006

Galectins are an ancient family of β-galactoside-specific lectins and consist of 15 different types, each with a specific function. They play a role in the immune system, inflammation, wound healing and carcinogenesis. In particular the role of gale

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac3f90910f971900dcfa3a97b6855590
https://doi.org/10.1016/j.vph.2016.02.006

Elevated monocyte-specific type I interferon signalling correlates positively with cardiac healing in myocardial infarct patients but interferon alpha application deteriorates myocardial healing in rats

Autor: Ellis N. ter Horst, Ingrid Lommerse, C. Ellen van der Schoot, Anja M. van der Laan, Felix Zijlstra, Paul A.J. Krijnen, Ruud D. Fontijn, Anton J.G. Horrevoets, Nazanin Hakimzadeh, Elisa Meinster, Robin Nijveldt, Albert C. van Rossum, Tineke C. T. M. van der Pouw Kraan, Alexander Hirsch, Hans W.M. Niessen, Niels van Royen, Lourens F. H. J. Robbers, Ronak Delewi, Jan J. Piek

Publikováno v: Basic Research in Cardiology, 114(1):1. D. Steinkopff-Verlag
Basic Research in Cardiology, 114(1). D. Steinkopff-Verlag
Basic Research in Cardiology, 114, 1
Ter Horst, E N, Krijnen, P A J, Hakimzadeh, N, Robbers, L F H J, Hirsch, A, Nijveldt, R, Lommerse, I, Fontijn, R D, Meinster, E, Delewi, R, van Royen, N, Zijlstra, F, van Rossum, A C, van der Schoot, C E, van der Pouw Kraan, T C T M, Horrevoets, A J, van der Laan, A M, Niessen, H W M & Piek, J J 2018, ' Elevated monocyte-specific type I interferon signalling correlates positively with cardiac healing in myocardial infarct patients but interferon alpha application deteriorates myocardial healing in rats ', Basic Research in Cardiology, vol. 114, no. 1, pp. 1 . https://doi.org/10.1007/s00395-018-0709-7
Basic research in cardiology, 114(1). D. Steinkopff-Verlag
Basic Research in Cardiology
Basic Research in Cardiology, 114

Monocytes are involved in adverse left ventricular (LV) remodelling following myocardial infarction (MI). To provide therapeutic opportunities we aimed to identify gene transcripts in monocytes that relate to post-MI healing and evaluated interventio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6113ea8911ac804c3179d656f6a35c13
https://pure.eur.nl/en/publications/aa832deb-049d-4807-9d89-be8fc281a8c0

Identification of HIF-2α-regulated genes that play a role in human microvascular endothelial sprouting during prolonged hypoxia in vitro

Autor: Susan Gibbs, Victor W.M. van Hinsbergh, Tineke C. T. M. van der Pouw-Kraan, Marloes van den Broek, Tessa D. Nauta, Pieter Koolwijk, Cees B.M. Oudejans

Publikováno v: Angiogenesis, 20(1), 39-54. Springer Netherlands
Angiogenesis
Nauta, T D, van den Broek, M, Gibbs, S, van der Pouw-Kraan, T C T M, Oudejans, C B, van Hinsbergh, V W M & Koolwijk, P 2017, ' Identification of HIF-2α-regulated genes that play a role in human microvascular endothelial sprouting during prolonged hypoxia in vitro ', Angiogenesis, vol. 20, no. 1, pp. 39-54 . https://doi.org/10.1007/s10456-016-9527-4
ANGIOGENESIS, 20(1), 39-54. Springer Netherlands

During prolonged hypoxic conditions, endothelial cells change their gene expression to adjust to the low oxygen environment. This process is mainly regulated by the hypoxia-inducible factors, HIF-1α and HIF-2α. Although endothelial cells do not for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99800ef719120fe2ee5718169badc606
https://research.vu.nl/en/publications/8307057a-f2fd-4fc3-9d0a-5f81dfc643f7

Systemic toll-like receptor and interleukin-18 pathway activation in patients with acute ST elevation myocardial infarction

Autor: Flip J.P. Bernink, Weena J.Y. Chen, Leo Timmers, Anton J.G. Horrevoets, Michaela Diamant, Cansu Yıldırım, J.M. Baggen, Pieter Koolwijk, Tineke C. T. M. van der Pouw Kraan, Niels van Royen, Albert C. van Rossum, Yolande Appelman, Aernout M. Beek

Publikováno v: Journal of Molecular and Cellular Cardiology, 67, 94-102. Academic Press Inc.
van der Pouw Kraan, C T M, Bernink, F J P, Yildirim, C, Koolwijk, P, Baggen, J M, Timmers, L, Beek, A M, Diamant, M, Chen, W J Y, van Rossum, A C, van Royen, N, Horrevoets, A J G & Appelman, J E A 2014, ' Systemic toll-like receptor and interleukin-18 pathway activation in patients with acute ST elevation myocardial infarction ', Journal of Molecular and Cellular Cardiology, vol. 67, pp. 94-102 . https://doi.org/10.1016/j.yjmcc.2013.12.021

Acute myocardial infarction (AMI) is accompanied by increased expression of Toll like receptors (TLR)-2 and TLR4 on circulating monocytes. In animal models, blocking TLR2/4 signaling reduces inflammatory cell influx and infarct size. The clinical con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::569d4be5377e9574f15a51d69a969f0c
https://doi.org/10.1016/j.yjmcc.2013.12.021