Výsledky vyhledávání - "C. Stanley Rooney"

Utilization of the chiral synthon, methyl 3-O-benzyl-2,4,6-trideoxy-6-iodo-α-D--hexopyranoside in the synthesis of a potent HMG-CoA reductase inhibitor

Autor: John D. Prugh, Harri G. Ramjit, A. A. Deana, C. Stanley Rooney

Publikováno v: Tetrahedron Letters. 26:2947-2950

Compound 1 , a potent synthetic HMG-CoA reductase inhibitor, has been synthesized from the chiral synthon, methyl 3-O-benzyl-2,4,6-trideoxy-6-iodo-α-D- erythro -hexopyranoside ( 2 ), utilizing a novel palladium-mediated procedure for benzyl ether cl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0b4606344f8cf5da8042263dd6e1358b
https://doi.org/10.1016/s0040-4039(00)98588-5

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Nucleophilic displacement of activated aryl triflates a new synthesis of oxindoles and arylacetic acids

Autor: Joseph G. Atkinson, Burton K. Wasson, José J. Fuentes, Yves Girard, C. Stanley Rooney, Edward L. Engelhardt

Publikováno v: Tetrahedron Letters. 20:2857-2860

2-Nitroaryl triflates undergo efficient base-catalyzed nucleophilic displacement by dimethyl malonate anion to yield dimethyl nitroarylmalonates, which subsequently are converted in high yields to nitroarylacetic acids and oxindoles.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eebd14f8cf7f93ecf9201cfd06ac3ec4
https://doi.org/10.1016/s0040-4039(01)86434-0

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Concerning the preparations of some pyridylimidazothiazole derivatives

Autor: Eva Eichler, Haydn W. R. Williams, C. Stanley Rooney

Publikováno v: Journal of Heterocyclic Chemistry. 20:419-421

The preparations of some 4-pyridylimidazo[2,1-b]thiazole and -imidazo[5,1-b]thiazole derivatives are described. In some of the cyclizations to form the imidazothiazole ring systems, trifluoroacetic anhydride, the dehydration reagent employed, partici

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0962382c209c7f6b7907ec3d9df12566
https://doi.org/10.1002/jhet.5570200228

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Chapter 17. Progress in Atherosclerosis Therapy: Hypolipidemic Agents

Autor: C. Stanley Rooney, John D. Prugh

Publisher Summary The importance of the lipoprotein transport system to the regulation of plasma lipid levels in human is firmly established. This system is responsible for delivering triglycerides (TG) primarily to adipose and muscle tissues and for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::00ffa6eba8dde75235cfb636e30b13a7
https://doi.org/10.1016/s0065-7743(08)60772-1

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Quantitative structure-activity relationships involving the inhibition of glycolic acid oxidase by derivatives of glycolic and glyoxylic acids

Autor: Haydn W. R. Williams, W. C. Randall, Paul S. Anderson, Eva Eichler, Stuart R. Michelson, Edward J. Cragoe, Emlen L. Cresson, Kermit B. Streeter, C. Stanley Rooney, Harvey Schwam

Publikováno v: Journal of medicinal chemistry. 22(6)

The enzyme glycolic acid oxidase oxidizes glycolate to glyoxylate and glyoxylate to oxalate. Three series of compounds related to the natural substrates, substituted glycolic, oxyacetic, and glyoxylic acids, have been investigated as inhibitors of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::324085e4d57b7b812fee21b434ebaa24
https://pubmed.ncbi.nlm.nih.gov/458816

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