Zobrazeno 1 - 10
of 333
pro vyhledávání: '"C. Stüber"'
Publikováno v:
Drugs in R&D, Vol 24, Iss 3, Pp 447-464 (2024)
Abstract Background and Objective Biological medicinal products improve patients’ lives, but access is limited, mainly due to high costs. Patents for many existing biological products are expiring, and generic versions, which are referred to as bio
Externí odkaz:
https://doaj.org/article/a884b82ff46844aba65a366c2b4ce507
Autor:
Jakob C. Stüber, Karin F. Rechberger, Saša M. Miladinović, Thomas Pöschinger, Tamara Zimmermann, Remi Villenave, Miro J. Eigenmann, Thomas E. Kraft, Dhaval K. Shah, Hubert Kettenberger, Wolfgang F. Richter
Publikováno v:
AAPS Open, Vol 8, Iss 1, Pp 1-18 (2022)
Abstract This study explores the impact of antibody surface charge on tissue distribution into various tissues including tumor. Tumor-bearing mice were dosed intravenously with a mixture comprising three antibodies engineered to carry negative charge
Externí odkaz:
https://doaj.org/article/7356f1aec7b84b8489b40eb563178c52
Autor:
Florian Kast, Martin Schwill, Jakob C. Stüber, Svende Pfundstein, Gabriela Nagy-Davidescu, Josep M. Monné Rodríguez, Frauke Seehusen, Christian P. Richter, Annemarie Honegger, Karen Patricia Hartmann, Thomas G. Weber, Felix Kroener, Patrick Ernst, Jacob Piehler, Andreas Plückthun
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
HER2 acts an oncogenic driver in numerous cancers. Here, the authors design an anti-HER2 biparatopic and tetravalent IgG fusion with inhibitory effects in a xenograft model.
Externí odkaz:
https://doaj.org/article/bbc4cba63fcc425a86335df0941f73d7
Autor:
Jakob C. Stüber, Christian P. Richter, Junel Sotolongo Bellón, Martin Schwill, Iwo König, Benjamin Schuler, Jacob Piehler, Andreas Plückthun
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Stüber et. al. show that receptor tyrosine kinase signaling can be neutralized through intermolecular, biparatopic bipDARPin crosslinking that locks down the bipDARPin-HER2 complexes. This affects the spatiotemporal organization and dynamics of HER2
Externí odkaz:
https://doaj.org/article/47e73f2b585647239c63400329c551bf
Autor:
Jakob C Stüber, Andreas Plückthun
Publikováno v:
PLoS ONE, Vol 14, Iss 12, p e0226579 (2019)
ObjectiveFluorescent labeling of specific cell-surface proteins enables a manifold of techniques to study their function in health and disease. A frequently cited family of methods employs phosphopantetheinyl transferases (PPTases) to attach probes,
Externí odkaz:
https://doaj.org/article/264b1f6971ea4692a4911a4928b51f52
Autor:
Martin Schwill, Jakob C. Stüber, Christian Richter, Junel Sotolongo Bellón, Benjamin Schuler, Iwo König, Jacob Piehler, Andreas Plückthun
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Communications Biology
Communications Biology
Overexpression of the receptor tyrosine kinase HER2 plays a critical role in the development of various tumors. Biparatopic designed ankyrin repeat proteins (bipDARPins) potently induce apoptosis in HER2-addicted breast cancer cell lines. Here, we ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b889c89635594a012365564977bb1bea
https://doaj.org/article/47e73f2b585647239c63400329c551bf
https://doaj.org/article/47e73f2b585647239c63400329c551bf
Autor:
Jakob C. Stüber, Karin F. Rechberger, Saša M. Miladinović, Thomas Pöschinger, Tamara Zimmermann, Remi Villenave, Miro J. Eigenmann, Thomas E. Kraft, Dhaval K. Shah, Hubert Kettenberger, Wolfgang F. Richter
This study explores the impact of antibody surface charge on tissue distribution into various tissues including tumor. Tumor-bearing mice were dosed intravenously with a mixture comprising three antibodies engineered to carry negative charge patches,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e366e898c5ae827d84ad0a80214d8142
https://doi.org/10.1101/2021.09.01.458024
https://doi.org/10.1101/2021.09.01.458024
Autor:
Annemarie Honegger, Jakob C. Stüber, Alexander Batyuk, Yufan Wu, Andreas Plückthun, Christian Jost
Publikováno v:
Protein Science. 26:1796-1806
The second member of the human ErbB family of receptor tyrosine kinases, HER2/hErbB2, is regarded as an exceptional case: The four extracellular subdomains could so far only be found in one fixed overall conformation, designated "open" and resembling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56681d1da1ef2ae9ee62aab825e59621
https://doi.org/10.1002/pro.3216
https://doi.org/10.1002/pro.3216
Cell surface proteins are key regulators of fundamental cellular processes and, therefore, often at the root of human diseases. Thus, a large number of targeted drugs which are approved or under development act upon cell surface proteins. Although do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b64bb03cf7fa9b585bfc7d7ed9abb50
https://www.zora.uzh.ch/id/eprint/174104/
https://www.zora.uzh.ch/id/eprint/174104/
Autor:
Andreas Plückthun, Jakob C. Stüber
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 12, p e0226579 (2019)
PLoS ONE, Vol 14, Iss 12, p e0226579 (2019)
ObjectiveFluorescent labeling of specific cell-surface proteins enables a manifold of techniques to study their function in health and disease. A frequently cited family of methods employs phosphopantetheinyl transferases (PPTases) to attach probes,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c923747b072de19860e6edb0893aad9
https://www.zora.uzh.ch/id/eprint/181245/
https://www.zora.uzh.ch/id/eprint/181245/