Zobrazeno 1 - 6
of 6
pro vyhledávání: '"C. Seth Pearson"'
Autor:
Marlene Belfort, Jing Zhang, Binbin Liu, Georges Belfort, Reza Nemati, Zhong Li, Dan Fabris, Matteo Scalabrin, C. Seth Pearson, Hongmin Li
Publikováno v:
Biotechnology and Bioengineering. 116:709-721
We have engineered an intein which spontaneously and reversibly forms a thiazoline ring at the native N-terminal Lys-Cys splice junction. We identified conditions to stablize the thiazoline ring and provided the first crystallographic evidence, at 1.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::687fd51bb2285308d4c8f20e3584ba3c
https://doi.org/10.1002/bit.26875
https://doi.org/10.1002/bit.26875
Autor:
B.T. Murray, Zachary A. Kloos, Georges Belfort, Kathleen A. McDonough, C. Seth Pearson, Pankaj Karande, Jun Ha Kwak, Monica Gupta, Ebot S. Tabe
Publikováno v:
Antimicrobial Agents and Chemotherapy. 60:2757-2764
Drug-resistant pathogens are a growing problem, and novel strategies are needed to combat this threat. Among the most significant of these resistant pathogens is Mycobacterium tuberculosis , which is an unusually difficult microbial target due to its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::816b79154233f6a4284c8f8193244624
https://doi.org/10.1128/aac.00940-15
https://doi.org/10.1128/aac.00940-15
Autor:
C Seth, Pearson, Reza, Nemati, Binbin, Liu, Jing, Zhang, Matteo, Scalabrin, Zhong, Li, Hongmin, Li, Dan, Fabris, Marlene, Belfort, Georges, Belfort
Publikováno v:
Biotechnology and bioengineering. 116(4)
We have engineered an intein which spontaneously and reversibly forms a thiazoline ring at the native N-terminal Lys-Cys splice junction. We identified conditions to stablize the thiazoline ring and provided the first crystallographic evidence, at 1.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::68798cdd857bf7c5814f14a88b73640a
https://pubmed.ncbi.nlm.nih.gov/30450538
https://pubmed.ncbi.nlm.nih.gov/30450538
Publikováno v:
Biomolecular NMR Assignments. 9:235-238
The backbone resonance assignments of an engineered splicing-inactive mini-RecA intein based on triple resonance experiments with [(13)C,(15)N]-labeled protein are reported. The construct contains inactivating mutations specifically designed to retai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df6aef2df8f6aeca573badf4a62cafd6
https://doi.org/10.1007/s12104-014-9581-z
https://doi.org/10.1007/s12104-014-9581-z
As pathogenic bacteria become resistant to traditional antibiotics, alternate approaches such as designing and testing new potent selective antimicrobial peptides (AMP) are increasingly attractive. However, whereas much is known regarding the relatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4710434bba520c843e12ccf760fc8320
https://europepmc.org/articles/PMC5207266/
https://europepmc.org/articles/PMC5207266/
Autor:
Alexander Shekhtman, C. Seth Pearson, Georges Belfort, Hongmin Li, Marlene Belfort, Cathleen M. Green, Zhong Li, Hon Kit Chan, Jing Zhang
Inteins, self-splicing protein elements, interrupt genes and proteins in many microbes, including the human pathogen Mycobacterium tuberculosis. Using conserved catalytic nucleophiles at their N- and C-terminal splice junctions, inteins are able to e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45d693fa9f61eea453942b5ee4ce2b6f
https://europepmc.org/articles/PMC5077202/
https://europepmc.org/articles/PMC5077202/