Zobrazeno 1 - 10 of 574 pro vyhledávání: '"C. Sergheraert"'
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Autor: C. Bergonzi, C. Sergheraert, E. Hollande, C. Gonindard, Alain Klaebe, L. Chavant, C. Denier
Publikováno v: Cell Biology and Toxicology. 13:141-153
The trypanocidal activity of naturally occurring 6-(3,4-dihydroxystyryl)-4-hydroxy-2-pyrone (hispidin) prompted us to examine its cytotoxic activity toward normal and cancerous cells in culture. Hispidin synthesized in our laboratory to a high degree
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7e2c5ca346df54b850fdfab2caf5a19f
https://doi.org/10.1023/a:1007321227010
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2
Trypanosoma cruzi: A 52-kDa Protein Sharing Sequence Homology with Glutathione S-Transferase Is Localized in Parasite Organelles Morphologically Resembling Reservosomes
Autor: M.A. Ouaissi, A. Tartar, C. Sergheraert, R. Schöneck, R. Fernandezgomez, Odile Billaut-Mulot, R. Gomezcorvera, J P Kusnierz, A. Taibi, Jean-François Dubremetz, Marc Loyens
Publikováno v: Experimental Parasitology. 81:453-461
We have previously isolated and characterized a Trypanosoma cruzi cDNA encoding a polypeptide with a molecular mass of 52 kDa (Tc52) sharing significant homology to glutathione S-transferase. In the present study, by molecular and immunological appro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac018cb8522ab79966747dfa2342b378
https://doi.org/10.1006/expr.1995.1138
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4
Potent and specific inhibitors of trypanothione reductase from Trypanosoma cruzi: bis(2-aminodiphenylsulfides) for fluorescent labeling studies
Autor: S, Girault, T E, Davioud-Charvet, L, Maes, J F, Dubremetz, M A, Debreu, V, Landry, C, Sergheraert
Publikováno v: Bioorganicmedicinal chemistry. 9(4)
In order to optimise the activity of bis(2-aminodiphenylsulfides) upon trypanothione reductase (TR) from Trypanosoma cruzi, a new series of bis(2-aminodiphenylsulfides) possessing three side chains was synthesized. Various moieties were introduced at
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4e6d4dfcbe099c88e52455f1a072de90
https://pubmed.ncbi.nlm.nih.gov/11354666
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5
2- and 3-substituted 1,4-naphthoquinone derivatives as subversive substrates of trypanothione reductase and lipoamide dehydrogenase from Trypanosoma cruzi: synthesis and correlation between redox cycling activities and in vitro cytotoxicity
Autor: MA Debreu, Elisabeth Davioud-Charvet, Simon L. Croft, RL Krauth-Siegel, S Kohler, C Sergheraert, L Salmon-Chemin, E Buisine, Landry, Yardley
Publikováno v: Journal of medicinal chemistry. 44(4)
Trypanothione reductase (TR) is both a valid and an attractive target for the design of new trypanocidal drugs. Starting from menadione, plumbagin, and juglone, three distinct series of 1,4-naphthoquinones (NQ) were synthesized as potential inhibitor
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ffc25d4ef880047cfa4ebf5ba22e701
https://pubmed.ncbi.nlm.nih.gov/11170645
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6
Cloning of Plasmodium falciparum protein disulfide isomerase homologue by affinity purification using the antiplasmodial inhibitor 1,4-bis[3-[N-(cyclohexyl methyl)amino]propyl]piperazine
Autor: I, Florent, E, Mouray, F, Dali Ali, H, Drobecq, S, Girault, J, Schrével, C, Sergheraert, P, Grellier, I, Florenta
Publikováno v: FEBS letters. 484(3)
A series of 10 1,4-bis(3-aminopropyl)piperazine compounds was found to display antiplasmodial activity with 50% growth inhibition between 30 and 250 nM, on three Plasmodium falciparum strains differently sensitive to chloroquine. By affinity chromato
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c495608aaa57831d039a081055ab4302
https://pubmed.ncbi.nlm.nih.gov/11078887
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7
Cholinergic-induced Ca2+ elevation in rat lacrimal gland acini is negatively modulated by PKCdelta and PKCepsilon
Autor: D, Zoukhri, R R, Hodges, C, Sergheraert, D A, Dartt
Publikováno v: Investigative ophthalmologyvisual science. 41(2)
To investigate the role of protein kinase C (PKC) in cholinergic agonist-induced Ca2+ elevation in lacrimal gland acini.Lacrimal gland acini were prepared by collagenase digestion, and changes in intracellular Ca2+ ([Ca2+]i) were measured using fura-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f34f64544762fcb25e1cfa46799f24ee
https://pubmed.ncbi.nlm.nih.gov/10670466
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9
Akademický článek
Synthesis, Structural Characterization, and Biological Evaluation of (E)-N-(4-Bromobenzylidene)-3-Methoxybenzohydrazide Monohydrate.
Autor: ANANTHI, KUMAR1 anathikumar13@gmail.com, ANANDALAKSHMI, HARIDHASS1 anandalakshmi74@yahoo.com, NEPOLRAJ, AMALADOSS2 akshayasaravanan21@gmail.com, AKSHAYA, SARAVANAN1 nepolraj@gmail.com
Publikováno v: Substantia: An International Journal of the History of Chemistry. Mar2024, Vol. 8 Issue 1, p25-38. 14p.
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10
Different protein kinase C isozymes mediate lower esophageal sphincter tone and phasic contraction of esophageal circular smooth muscle
Autor: U D, Sohn, D, Zoukhri, D, Dartt, C, Sergheraert, K M, Harnett, J, Behar, P, Biancani
Publikováno v: Molecular pharmacology. 51(3)
Circular muscle of the esophagus (ESO) is normally relaxed and contracts phasically in response to neural stimuli. In contrast, lower esophageal sphincter (LES) circular muscle maintains spontaneous tone and relaxes in response to neural stimuli. We
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c504735481b1079e02cec65a86621097
https://pubmed.ncbi.nlm.nih.gov/9058601
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